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Monoclonal Antibodies

Other Monoclonal Antibodies

Anti Human Lymphocyte

Anti Mouse Cytokine

Anti Human Cytokine

Anti Mouse Lymphocyte

Anti-GST Monoclonal

Anti Viral Monoclonal

Anti Human Heat Shock Protein

Anti Human Enzyme

Product List

DNAL1 Antibody

Dynein Axonemal Light Chain 1, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT16320

Appearance

The solution is colorless, sterile, and filtered.

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DYNLL1 Antibody

Dynein Light Chain LC8 Type-1, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT16396

Appearance

The product is a colorless solution that has been sterilized by filtration.

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EDAR Antibody

Ectodysplasin A Receptor, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT16465

Appearance

Clear, colorless solution that has been sterilized by filtration.

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TBCB Antibody

Tubulin Folding Cofactor B, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1169

Appearance

Sterile, colorless solution.

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TBCEL Antibody

Tubulin Folding Cofactor E-Like, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1258

Appearance

Sterile filtered colorless solution.

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Tetanus antibody

Tetanus toxoid scFv Recombinant antibody

Tetanus toxin, produced by the bacterium Clostridium tetani under anaerobic conditions, is responsible for causing tetanus. This recombinant Anti-Tetanus antibody, produced in E. coli, is a non-glycosylated polypeptide chain with a molecular weight of 37 kDa. It features a hexahistidine tag and undergoes purification through proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT1312

Source

Escherichia Coli.

Appearance

A clear solution that has been sterilized by filtration.

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TLR2 Antibody

Toll-like receptor 2, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1403

Appearance

Clear, colorless solution, sterilized by filtration.

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SNCA (1-140) Antibody

Alpha-Synuclein (Immunogen 1-140 a.a.), Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT285

Appearance

A clear, sterile-filtered solution.

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SNCA Antibody

Alpha-Synuclein, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT346

Appearance

Sterile Filtered colorless solution.

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SNTA1 Antibody

Syntrophin, Alpha 1, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT412

Appearance

The product appears as a clear, colorless liquid that has been sterilized by filtration.

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Introduction

Definition and Classification

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are produced by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can be classified based on their source and structure:

Murine mAbs: Derived from mouse cells.
Chimeric mAbs: Contain both human and mouse components.
Humanized mAbs: Mostly human, with only small mouse-derived components.
Human mAbs: Fully human antibodies.

Biological Properties

Monoclonal antibodies exhibit several key biological properties:

Protein Sequence: Identical protein sequences and antigen-binding sites.
Expression Patterns: Produced by B lymphocytes and expressed in hybridoma cells.
Tissue Distribution: Can be designed to target specific tissues or cells, such as cancer cells.

Biological Functions

Monoclonal antibodies play crucial roles in the immune system:

Pathogen Recognition: Bind to specific antigens on pathogens, marking them for destruction.
Immune Response: Enhance the immune system’s ability to fight infections and diseases.
Therapeutic Functions: Used in treating various diseases, including cancer, autoimmune disorders, and infectious diseases.

Modes of Action

Monoclonal antibodies interact with other molecules and cells through various mechanisms:

Binding Partners: Bind to specific antigens on target cells.
Downstream Signaling Cascades: Trigger immune responses by activating immune cells and complement systems.
Effector Functions: Engage Fc receptors on immune cells, leading to cell-mediated cytotoxicity.

Regulatory Mechanisms

The expression and activity of monoclonal antibodies are tightly regulated:

Transcriptional Regulation: Controlled by specific transcription factors that regulate the expression of antibody genes.
Post-Translational Modifications: Undergo modifications such as glycosylation, which can affect their stability and function.

Applications

Monoclonal antibodies have a wide range of applications in biomedical research and medicine:

Diagnostic Tools: Used in assays to detect specific antigens in samples.
Therapeutic Strategies: Employed in the treatment of cancers, autoimmune diseases, and infectious diseases.
Biomedical Research: Serve as tools to study cellular processes and disease mechanisms.

Role in the Life Cycle

Monoclonal antibodies play roles throughout the life cycle:

Development: Used in prenatal diagnostics and treatments.
Aging: Help manage age-related diseases such as cancer and Alzheimer’s.
Disease: Provide targeted therapies for various diseases, improving patient outcomes.