Monoclonal Antibodies
Product List
VIM Monoclonal Antibody
This product is a mouse monoclonal antibody generated against the recombinant protein corresponding to the full length of human vimentin. The VIM antibody is an unconjugated IgG isoform. Its quality has been rigorously validated through ELISA and WB testing. This antibody demonstrates reactivity with human, mouse, and rat samples. Importantly, it exhibits no cross-reactivity with other closely related intermediate filament (IF) proteins, such as keratin. The VIM antibody specifically binds to vimentin, a mesenchymal cell-expressed IF protein that plays a crucial role in maintaining cellular integrity, stabilizing cytoskeletal interactions, and providing resistance to cellular damage.
Introduction
Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells . They are produced by identical immune cells that are all clones of a unique parent cell . Monoclonal antibodies can be classified based on their source and structure:
Monoclonal antibodies exhibit several key biological properties:
Monoclonal antibodies play crucial roles in the immune system:
- Pathogen Recognition: Bind to specific antigens on pathogens, marking them for destruction .
- Immune Response: Enhance the immune system’s ability to fight infections and diseases .
- Therapeutic Functions: Used in treating various diseases, including cancer, autoimmune disorders, and infectious diseases .
Monoclonal antibodies interact with other molecules and cells through various mechanisms:
The expression and activity of monoclonal antibodies are tightly regulated:
Monoclonal antibodies have a wide range of applications in biomedical research and medicine:
