Recombinant Human Platelet-derived growth factor subunit A (PDGFA) (Active)

1. Elevated PDGF expression is associated with cardiac fibrosis. PMID: 30340644
2. Hypomethylation at a CpG site in PDGFA and PDGFA overexpression are both linked to increased T2 diabetes risk, hyperinsulinemia, heightened insulin resistance, and increased steatohepatitis risk. PMID: 29728363
3. PDGFA expression was downregulated in malignant Middle Cerebral Artery Infarction. PMID: 28828208
4. Research highlights a novel mechanism of the Nrf2/PDGFA regulatory loop that is crucial for AKT-dependent hepatocellular carcinoma progression. PMID: 27588483
5. Tumor cell-induced mesenchymal stromal cell chemotaxis appears to be mediated through paracrine secretion of PDGF-AA. PMID: 27931212
6. PDGFAA in tumor drainage and HER2 in peripheral vein blood may contribute to synchronous liver metastasis of colorectal cancer. PMID: 28275303
7. Insulin treatment led to sustained Akt activity, while EGF or PDGF-AA promoted transient signaling. PDGF-BB produced sustained responses at higher concentrations. Transient responses to EGF were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I caused full Akt activation. PMID: 27044757
8. These findings suggest that IGFBP-3 suppresses transcription of EGR1 and its target genes bFGF and PDGF by inhibiting IGF-1-dependent ERK and AKT activation. PMID: 27521890
9. Based on a luciferase reporter assay, platelet-derived growth factor A (PDGFA) was identified as a direct target gene of miR375. Additionally, overexpression of PDGFA significantly reversed the effect of miR375 on cell migration and invasion in oral squamous cell carcinoma cells. PMID: 28000902
10. The highest PDGF AA levels were found in mothers of fetuses with hypoplastic left heart syndrome. These findings may be useful in screening for congenital heart defects (CCHDs) and offer insight into their association with nuchal translucency. PMID: 28323386
11. Low concentrations of PDGF-AB showed synergism with IFN-alpha in IFN-beta and -gamma induction. PMID: 24063997
12. Downregulated Rab5a led to slowed cell growth, decreased numbers of migrated cells, decreased numbers of cells at the G0G1 phase and a higher apoptosis rate. However, PDGF significantly rescued these phenomena caused by siRNA against Rab5a. PMID: 27666726
13. There are four platelet-derived growth factor (PDGF) genes (PDGFA, PDGFB, PDGFC and PDGFD) that reside on chromosomes 7, 22, 4 and 11. PMID: 28267575
14. TLR-stimulated pancreatic cancer cells were specifically investigated for activated signaling pathways of VEGF/PDGF and anti-apoptotic Bcl-xL expression as well as tumor cell growth. PMID: 27941651
15. Nox4 and Duox1/Duox2 mediate redox activation of mesenchymal cell migration by PDGF. PMID: 27110716
16. In contrast to platelet-derived growth factor, all urokinase isoforms induced secretion of MMP-9 by mesenchymal stromal cells. PMID: 27783304
17. Normalization of bone marrow microenvironment is paralleled by decreased expression of TIMP and PDGFA. PMID: 26708839
18. In primary cultures of glioma stemlike cells, EGR1 contributes to stemness marker expression and proliferation by orchestrating a PDGFA-dependent growth-stimulatory loop. PMID: 27002148
19. These findings implicate DNA hypomethylation as a specific factor in mediating overexpression of genes associated with Biliary Atresia (BA) and identify PDGFA as a new candidate in BA pathogenesis. PMID: 27010479
20. Human uPAR activation and its association with beta1-integrin are required for PDGF-AB-induced migration. PMID: 26420039
21. PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1/5- and SMAD4-dependent mechanisms. PMID: 26769046
22. The development and severity of age-related cataracts was related to the secretion and expression of PDGF-alpha. PMID: 26535645
23. PDGF and TGFbeta1 regulate acute respiratory distress syndrome-associated lung fibrosis through distinct signaling pathway-mediated activation of fibrosis-related proteins. PMID: 26088859
24. Research demonstrates a novel positive regulatory feedback loop between FoxM1 and the PDGF-A/AKT signaling pathway, which contributes to breast cancer cell growth and tumorigenesis. PMID: 25869208
25. Evidence suggests the involvement of PDGF, IGF-1, and EGF in primary pulmonary hypoplasia. PDGF deficiency plays a role in secondary pulmonary hypoplasia. PMID: 26841646
26. MIC-1 and PDGF-A expression is elevated in both prostate tumors and structurally intact adjacent tissues. PMID: 25767870
27. This review elucidates the role of tumor stroma interactions, the roles of PDGF receptor signaling in cancer-associated fibroblasts via alteration of stromal matrix composition and the mitogenic effects of cancer-derived PDGFs. PMID: 23944365
28. Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts. PMID: 25686533
29. Findings revealed how FoxM1 activates expression of PDGF-A and STAT3 in a pathway required to maintain the self-renewal and tumorigenicity of glioma stem-like cells. PMID: 25832656
30. Patients with Graves ophthalmopathy had significantly higher serum levels of PDGF-AA than controls. Immunosuppressive therapy eliminated differences. PMID: 25140996
31. AVP stimulates myofibroblast proliferation and induces PDGFA secretion, suggesting that PDGFA mediates local myofibroblast proliferation by an autocrine feedback loop and regulates epithelial proliferation and permeability by a paracrine mechanism. PMID: 25085844
32. VEGF, PDGF, and TGF-beta1 concentrations in platelets may be associated with prognosis of breast cancer. PMID: 25379550
33. Both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization. PMID: 24995287
34. PDGFA is a SOX11 direct target gene upregulated in MCL cells whose inhibition impaired SOX11-enhanced in vitro angiogenic effects on endothelial cells. PMID: 25092176
35. Research demonstrated that PDGFRA activation supported tumor cell proliferation. PMID: 24480986
36. PDGF positively modulates the TGF-beta-induced osteogenic differentiation of hMSCs through synergistic crosstalk between MEK- and PI3K/Akt-mediated signaling. PMID: 24378341
37. The suppressive effects of PDGF-BB on Ca(2+) overload in neurons were more potent than those of PDGF-AA. PMID: 24454980
38. The mRNA expressions of the proangiogenic growth factors VEGF, PDGF, bFGF and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared in gastric ulcers of cirrhotic patients. PMID: 23620752
39. Studies established that loss of SMAD1/5 leads to upregulation of PDGFA in ovarian granulosa cells. PMID: 22964636
40. Platelet-derived growth factor-A and vascular endothelial growth factor-C might induce intimal proliferation in pulmonary arteries and contribute to the development of pulmonary tumor thrombotic microangiopathy. PMID: 23536282
41. Research shows that VEGF was downregulated while platelet-derived growth factor-A (PDGF-A) was upregulated when IFN-alpha treatment was re-initiated. PMID: 23025904
42. Findings suggest a role for brain-derived neurotropic factor (BDNF) and platelet-derived growth factors PDGF-AA in the pathophysiological mechanism of cerebrovascular disease in sickle cell anemia (SCA). PMID: 22704695
43. Results suggest that PDGFA may be used for cholangiocarcinoma prognosis and/or as a diagnostic candidate marker. PMID: 22733151
44. Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that are required for proper development of endoderm-derived organs, such as the lung. PMID: 22949635
45. A significant positive correlation was observed between serum PDGF-AB & microvascular density in multiple myeloma, & between pre- & post-treatment patients. PDGF-AB plays a role in a complex cytokine network inducing bone marrow neovascularization. PMID: 21919032
46. Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility. PMID: 22588000
47. The kidney participates in the elimination of IL-6 and PDGF from systemic circulation. The kidney does not participate in the elimination of TGF-beta. PMID: 22617683
48. Analysis of astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment. PMID: 22393407
49. This study was the first to demonstrate that CSF PDGF-AA is related to disease duration in relapsing-remitting multiple sclerosis. PMID: 21771201
50. SiO(2) may affect the expression of PDGF and synthesis of collagen through alveolar macrophage mediation and participate in the formation of lung fibrosis. PMID: 19493486

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HGNC: 8799

OMIM: 173430

KEGG: hsa:5154

STRING: 9606.ENSP00000346508

UniGene: Hs.535898