SCGB2A2 Human, HEK
Description
Oncology
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Breast Cancer Biomarker: SCGB2A2 (mammaglobin-A) is overexpressed in 85% of breast carcinomas, making it a sensitive marker for detecting metastatic breast cancer cells .
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Co-Expression with Lipophilin B: Forms a covalent complex with SCGB1D2 (lipophilin B) in breast tumors, enhancing diagnostic specificity .
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Therapeutic Target: Investigated for antibody-drug conjugates due to its tumor-selective expression .
Immunology
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Immune Signaling: Secretoglobins modulate chemotaxis and inflammation, with SCGB2A2 implicated in mucosal immunity .
Production and Quality Control
SCGB2A2 Human, HEK is manufactured under stringent conditions:
Expression Analysis
A study of 309 tumors revealed:
Product Specs
Sterile filtered lyophilized powder.
SCGB2A2 was filtered (0.4 μm) and lyophilized from a 0.5 mg/ml solution in PBS buffer containing 5% (w/v) Threalose at a pH of 7.4.
To prepare a working stock solution, it is recommended to add deionized water to achieve a concentration of approximately 0.5 mg/ml and allow the lyophilized pellet to dissolve completely. Please note that this product is not sterile. Before using it on cell culture, it is essential to filter the product through an appropriate sterile filter.
Store the lyophilized protein at -20 °C. To prevent repeated freezing and thawing cycles, it is advisable to aliquot the product after reconstitution. Once reconstituted, the protein can be stored at 4 °C for up to 5 days.
Product Science Overview
Mammaglobin-A, also known as secretoglobin family 2A member 2 (SCGB2A2), is a protein encoded by the SCGB2A2 gene in humans . This protein is a member of the secretoglobin superfamily, which consists of small, dimeric, secreted, and sometimes glycosylated proteins . Mammaglobin-A is primarily expressed in the mammary tissue and has gained significant attention due to its potential role in breast cancer diagnosis and treatment .
Mammaglobin-A is a 93-amino acid glycoprotein . It forms a heterodimer with lipophilin B, another member of the secretoglobin family . The exact function of Mammaglobin-A remains unclear, but it is believed to be involved in cell signaling, immune response, and chemotaxis . Additionally, secretoglobins, including Mammaglobin-A, may serve as transporters for steroid hormones in humans .
Mammaglobin-A expression is highly specific to mammary tissue, making it a valuable marker for identifying and detecting disseminated breast cancer cells . Its expression is frequently observed in breast epithelial cells, and it is used as a diagnostic marker for breast cancer . Moreover, Mammaglobin-A represents an attractive target for novel therapies involving adaptive T cell transfer and antitumor vaccines for breast cancer patients .
Recent studies have shown that Mammaglobin-A expression is not limited to breast cancers. It has been found in tumors derived from the female genital tract and salivary glands . Immunohistochemistry analysis of a tissue microarray containing samples from various tumor types and normal tissues revealed Mammaglobin-A positivity in several tumor categories . This highlights the potential use of anti-Mammaglobin therapies in other Mammaglobin-positive tumor types .
