Recombinant Proteins

p53
LBP
CEA
HLA
TCL
TTC
NPM
MAF
Bax
BID

SCGB1D1 Human

Secretoglobin Family 1D, Member 1 Human Recombinant

Recombinantly produced in E. coli, SCGB1D1 Human Recombinant is a single, non-glycosylated polypeptide chain consisting of 79 amino acids (a.a 22-90), including a 10 a.a N-terminal His tag. The calculated molecular mass is 8.8kDa.
Shipped with Ice Packs
Cat. No.
BT20682
Source
Escherichia Coli.
Appearance
White lyophilized powder, filtered.

SCGB2A2 Human, HEK

Mammaglobin-A Human Recombinant, HEK

Produced in HEK cells, Recombinant Human Mammaglobin-A (Fc Chimera) is a single, glycosylated polypeptide chain (Gly19-Phe93). It contains a total of 321 amino acids, with a calculated molecular mass of 36.3 kDa. The SCGB2A2 protein is fused to a 2 aa C-terminal linker, a 6 aa C-terminal His tag, a 7 aa TEV site, and a 231 aa Human IgG1 fragment (Pro100-Lys330).
Shipped with Ice Packs
Cat. No.
BT20755
Source
HEK 293.
Appearance

Sterile filtered lyophilized powder.

SCGB3A2 Human

Secretoglobin Family 3A Member 2 Human Recombinant

Recombinant human SCGB3A2, produced in E. coli, is a non-glycosylated homodimeric protein. It consists of two chains, each comprising 79 amino acids (Phe22-Val93), connected by a 6-amino acid linker. A 6-amino acid Histidine tag is present at the C-terminus, resulting in a total molecular weight of 17.1 kDa.
Shipped with Ice Packs
Cat. No.
BT20831
Source
Escherichia Coli.
Appearance
Clear, colorless solution.
Definition and Classification

Secretoglobins (SCGBs) are a family of small, alpha-helical, disulfide-linked, dimeric proteins found exclusively in mammals . They were previously known as the Uteroglobin/Clara cell 10-kDa family, named after their founding member Uteroglobin . The family is classified into several subfamilies based on sequence homology .

Biological Properties

Key Biological Properties: Secretoglobins are relatively small, secreted proteins with a molecular weight of approximately 10 kDa . They form dimers through disulfide bridges and have a large hydrophobic pocket that can bind small to medium-sized ligands like steroids and phospholipids .

Expression Patterns and Tissue Distribution: Secretoglobins are predominantly expressed in secretory tissues of barrier organs such as the lungs, lacrimal glands, salivary glands, prostate glands, and uterus . They are highly abundant in the respiratory tract and can also be detected in malignant tissues .

Biological Functions

Primary Biological Functions: Secretoglobins play a crucial role in immunoregulatory and anti-inflammatory processes . They are involved in modulating inflammation, tissue repair, and tumorigenesis .

Role in Immune Responses and Pathogen Recognition: Secretoglobins are embedded in Th1 and Th2 immune responses and are expressed in a manner dependent on cell maturation . They react to cytokines and are critical elements of innate immune control at epithelial barriers .

Modes of Action

Mechanisms with Other Molecules and Cells: Secretoglobins interact with various molecules and cells through their hydrophobic pockets, which can bind steroids and phospholipids .

Binding Partners and Downstream Signaling Cascades: For example, SCGB3A2 chaperones lipopolysaccharides (LPS) to the cytosol, activating caspase-11 and the non-canonical inflammasome pathway, leading to pyroptosis .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: Secretoglobins are differentially regulated by inflammatory cytokines . They are embedded in Th1 and Th2 immune responses and are expressed in a manner dependent on cell maturation .

Transcriptional Regulation and Post-Translational Modifications: The expression of secretoglobins is controlled by various transcription factors and signaling pathways, including NFκB/RelA-TGFβ signaling .

Applications

Biomedical Research: Secretoglobins are used in research to understand their role in immune regulation and inflammation .

Diagnostic Tools: Due to their high abundance in the respiratory tract and involvement in diseases, secretoglobins can serve as biomarkers for diagnostic assessment of epithelial activity .

Therapeutic Strategies: Secretoglobins have potential therapeutic applications in treating inflammatory and autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease .

Role in the Life Cycle

Role Throughout the Life Cycle: Secretoglobins play a role in various stages of life, from development to aging and disease . They are involved in the modulation of inflammation, tissue repair, and tumorigenesis, making them critical for maintaining homeostasis and responding to pathological conditions .

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