Recombinant Proteins

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AZGP1 Human

Alpha-2-Glycoprotein 1 Zinc-Binding Human

Human Zinc-Alpha 2 Glycoprotein, derived from Human Serum, has a molecular weight of 32.14 kDa (excluding glycosylation) and comprises 278 amino acids.
Shipped with Ice Packs
Cat. No.
BT27395
Source
Human Serum.
Appearance
White, lyophilized powder after filtration.

AZGP1 Human, HEK

Alpha-2-Glycoprotein 1 Zinc-Binding Human Recombinant, HEK

Recombinant human ZA2G, produced in HEK cells, is a single, glycosylated polypeptide chain consisting of 290 amino acids, encompassing residues 13 to 290. This recombinant protein is identical to the Swiss-Prot entry P25311 (amino acids 18-295), representing the mature form of Zinc-Alpha-2-Glycoprotein. An additional twelve amino acids have been added to the N-terminus.
Shipped with Ice Packs
Cat. No.
BT27524
Source
293 Cell Line (Human Embryonic Kidney).
Appearance
White, lyophilized powder after filtration.

JAZF1 Human

JAZF zinc finger 1 Human Recombinant

This product consists of the recombinant human JAZF1 protein. It is produced in E.Coli and is a single, non-glycosylated polypeptide chain of 266 amino acids (amino acids 1-243). The molecular weight of this protein is 29.5kDa. For purification purposes, a 23 amino acid His-tag is fused to the N-terminus of JAZF1. The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT27622
Source
Escherichia Coli.
Appearance
The product is a sterile, colorless solution that has been filtered.

MORC3 Human

MORC Family CW-Type Zinc Finger 3 Human Recombinant

Recombinant Human MORC Family CW-Type Zinc Finger 3, produced in SF9 insect cells, is a glycosylated polypeptide chain with a calculated molecular mass of 122 kDa. It is expressed with a 10xHis tag and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT27697
Source

Sf9 insect cells.

Appearance
Sterile Filtered clear solution.

RCHY1 Human

Ring Finger & CHY Zinc Finger Domain Containing 1 Human Recombinant

RCHY1 Human Recombinant, produced in E. coli, is a single polypeptide chain comprising 284 amino acids (1-261) with a molecular weight of 32.5kDa. A 23 amino acid His-tag is fused to the N-terminus of RCHY1, which is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT27789
Source
Escherichia Coli.
Appearance
A clear solution that has undergone sterile filtration.

ZG16 Human

Zymogen Granule Protein 16 Homolog Human Recombinant

Recombinant human ZG16, produced in E. coli, is a single polypeptide chain of 174 amino acids (residues 17-167) with a molecular weight of 19 kDa. A 23 amino acid His-tag is fused to the N-terminus of ZG16. The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28186
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile-filtered solution.

ZNF689 Human

Zinc Finger Protein 689 Human Recombinant

Recombinant ZNF689 Human is produced in E. coli. It is a single, non-glycosylated polypeptide chain containing 523 amino acids (1-500a.a) and has a molecular mass of 59.3kDa. ZNF689 is fused to a 23 amino acid His-tag at the N-terminus and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28589
Source
Escherichia Coli.
Appearance
Sterile, colorless solution.

ZNHIT1 Human

Zinc Finger HIT-Type Containing 1 Human Recombinant

Recombinant human ZNHIT1, produced in E. coli, is a single, non-glycosylated polypeptide chain composed of 177 amino acids (residues 1-154). It has a molecular weight of 19.9 kDa and includes a 23 amino acid His-tag at the N-terminus.
Shipped with Ice Packs
Cat. No.
BT28684
Source
Escherichia Coli.
Appearance
The product is a sterile, colorless solution.

ZNHIT3 Human

Zinc Finger HIT-Type Containing 3 Human Recombinant

Recombinant human ZNHIT3, expressed in E. coli, is a non-glycosylated polypeptide chain consisting of 178 amino acids (residues 1-155) with a molecular weight of 20 kDa. This protein is purified using proprietary chromatographic techniques and is fused to a 23 amino acid His-tag at its N-terminus.
Shipped with Ice Packs
Cat. No.
BT28782
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile-filtered solution.

ZMAT3 Human

Zinc Finger, Matrin-Type 3 Human Recombinant

Recombinant human ZMAT3, expressed in E. coli, is a single polypeptide chain that is not glycosylated. It comprises 312 amino acids (residues 1-289) and exhibits a molecular weight of 34.4 kDa. A 23 amino acid His-tag is fused to the N-terminus of the ZMAT3 protein. Purification is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28241
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
Definition and Classification

Zinc fingers are small protein structural motifs characterized by the coordination of one or more zinc ions (Zn²⁺) which stabilize the fold . These motifs were first identified in the transcription factor IIIA from the African clawed frog (Xenopus laevis) . Zinc fingers are classified into several structural families based on their three-dimensional architecture and the identity of the ligands coordinating the zinc ion. The most common types include C2H2, C4, and C6 zinc fingers .

Biological Properties

Zinc finger proteins (ZFPs) are ubiquitous in eukaryotic cells and play crucial roles in various biological processes. They are primarily found in the nucleus, where they function as transcription factors . ZFPs exhibit diverse expression patterns and tissue distribution, being present in almost all tissues but with varying abundance . They are involved in gene regulation, cell differentiation, and embryonic development .

Biological Functions

ZFPs primarily function as transcription factors, regulating the expression of genes by binding to specific DNA sequences . They play significant roles in immune responses and pathogen recognition by regulating the transcription of genes involved in these processes . Additionally, ZFPs are implicated in cell differentiation, embryonic development, and various diseases, including cancers .

Modes of Action

Zinc fingers interact with DNA, RNA, proteins, and other small molecules . They bind to specific DNA sequences through their finger-like protrusions, facilitating the regulation of gene transcription . ZFPs can also interact with other proteins to form complexes that modulate downstream signaling cascades . These interactions are crucial for the regulation of various cellular processes, including metabolism, autophagy, and apoptosis .

Regulatory Mechanisms

The expression and activity of ZFPs are tightly regulated at both the transcriptional and post-transcriptional levels . Transcriptional regulation involves the binding of ZFPs to promoter regions of target genes, modulating their expression . Post-translational modifications, such as phosphorylation and ubiquitination, further regulate the activity and stability of ZFPs . These regulatory mechanisms ensure precise control over the biological functions of ZFPs.

Applications

Zinc fingers have become invaluable tools in biomedical research and therapeutic strategies. Engineered zinc finger nucleases (ZFNs) are used for gene editing, allowing precise modifications of the genome . ZFPs are also employed in diagnostic tools to detect specific DNA sequences associated with diseases . Additionally, ZFPs hold potential as therapeutic agents for treating genetic disorders and cancers .

Role in the Life Cycle

ZFPs play essential roles throughout the life cycle, from development to aging and disease . During embryonic development, ZFPs regulate the expression of genes involved in cell differentiation and organogenesis . In adulthood, they continue to modulate gene expression in response to various stimuli, maintaining cellular homeostasis . Dysregulation of ZFPs is associated with aging and the development of diseases, including neurodegenerative disorders and cancers .

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