Recombinant Proteins
Product List
ORM2 Human, sf9
Orosomucoid 2 Human Recombinant, sf9
ORM1
Orosomucoid 1 Human Recombinant
ORM1 Human
Orosomucoid 1 Human
ORM1 Human, HEK
Orosomucoid 1 Human Recombinant, HEK
HEK293
ORM2 Human
Orosomucoid 2 Human Recombinant
Introduction
Orosomucoid, also known as alpha-1-acid glycoprotein (AGP), is an acute-phase protein found in plasma. It is an alpha-globulin glycoprotein modulated by two polymorphic genes . Orosomucoid is primarily synthesized in hepatocytes and has a normal plasma concentration between 0.6–1.2 mg/mL, accounting for 1–3% of plasma proteins .
Key Biological Properties: Orosomucoid has a molecular weight of 37–54 kDa and a low isoelectric point (pI) of 2.8–3.8. It is heavily glycosylated, with carbohydrate content making up 45% of its structure .
Expression Patterns: Orosomucoid is mainly synthesized by the liver, but many extrahepatic tissues also produce it under various physiological and pathological conditions .
Tissue Distribution: While predominantly found in plasma, orosomucoid is also expressed in other tissues such as the brain and adipose tissue .
Primary Biological Functions: Orosomucoid acts as an acute-phase reactant and disease marker. It modulates immunity, binds and carries drugs, maintains the barrier function of capillaries, and mediates sphingolipid metabolism .
Role in Immune Responses: Orosomucoid plays a crucial role in modulating immune responses by interacting with immune cells and influencing their activity .
Pathogen Recognition: It is involved in the recognition and response to pathogens, contributing to the body’s defense mechanisms .
Mechanisms with Other Molecules and Cells: Orosomucoid interacts with various molecules and cells, including binding to receptors such as CCR5, Siglect-5, and HBB on macrophages, neutrophils, and liver parenchymal cells .
Binding Partners: It binds to basic and neutrally charged lipophilic compounds, including drugs, steroids, and protease inhibitors .
Downstream Signaling Cascades: Orosomucoid influences downstream signaling pathways, such as the MEK/ERK pathway, which is essential for angiogenesis .
Biomedical Research: Orosomucoid is used as a marker in various research studies to understand its role in diseases and immune responses .
Diagnostic Tools: It serves as a biomarker for inflammatory conditions and certain diseases, aiding in diagnosis .
Therapeutic Strategies: Orosomucoid’s ability to modulate immune responses and bind to drugs makes it a potential target for therapeutic interventions .
