Recombinant Proteins

CEA
p53
LBP
HLA
TCL
TTC
NPM
MAF
Bax
BID

CEACAM3 Human

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 Human Recombinant

Recombinant Human CEACAM3, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 144 amino acids (35-155 a.a). It has a molecular weight of 15.5 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT4773
Source
Escherichia Coli.
Appearance
A clear, sterile, and filtered solution.

CEACAM3 Human, Sf9

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 Human Recombinant, Sf9

Recombinant Human CEACAM3, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain consisting of 130 amino acids (35-155a.a.). It exhibits a molecular mass of 14.2kDa (although it may appear between 13.5-18kDa on SDS-PAGE). CEACAM3 is expressed with a C-terminal 6-amino acid His tag and purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT4837
Source
Sf9, Baculovirus cells.
Appearance
Sterile Filtered colorless solution.

CEACAM6 Human

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 Recombinant Human

Recombinant human CEACAM6, expressed in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain. It consists of 297 amino acids (residues 35-320), resulting in a molecular mass of 32.6 kDa. Note: SDS-PAGE analysis may show a molecular size of approximately 40-57 kDa. The protein includes a C-terminal 6-amino acid His-Tag and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT4913
Source
Sf9, Baculovirus cells.
Appearance
Clear, sterile-filtered solution.

CEACAM7 Human

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 Human Recombinant

Recombinant human CEACAM7, expressed in E. coli, is a single, non-glycosylated polypeptide chain composed of 230 amino acids (residues 36-242). It has a molecular weight of 25.7 kDa. This protein includes a 23-amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5009
Source
Escherichia Coli.
Appearance
The product is a clear solution that has been sterilized by filtration.

CEA Human

Carcinoembryonic Antigen Human Recombinant

Recombinant Human CEA is a glycosylated protein produced using baculovirus vectors in insect cells. It has N-linked sugars. This tumor marker corresponds to the full-length human CEA, with an approximate molecular weight of 120,000 Daltons.
Shipped with Ice Packs
Cat. No.
BT4423
Source
Baculovirus Insect Cells.
Appearance
The product is a clear and colorless solution that has been sterilized by filtration.

CEA Human, His

Carcinoembryonic Antigen Human Recombinant, His Tag

CEA Human Recombinant, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain containing 659 amino acids (35-685a.a.). It has a molecular mass of 72.3kDa (Molecular size on SDS-PAGE appears approximately at 70-150kDa). The recombinant CEA is expressed with an 8 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT4530
Source
Sf9, Baculovirus cells.
Appearance
Sterile Filtered colorless solution.

CEACAM1 Human

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Human Recombinant

Produced in Sf9 Baculovirus cells, CEACAM1 is a single, glycosylated polypeptide chain consisting of 405 amino acids (35-428 a.a.). It has a molecular mass of 44.6 kDa. However, on SDS-PAGE, the molecular size appears approximately between 40-70 kDa. The protein is expressed with a 6 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT4605
Source
Sf9, Baculovirus cells.
Appearance
Sterile Filtered colorless solution.

CEACAM21 Human

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 21 Human Recombinant

Recombinant human CEACAM21, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 229 amino acids (35-240). It possesses a molecular mass of 25.0 kDa. A 23 amino acid His-tag is fused to the N-terminus of CEACAM21. Purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT4681
Source
Escherichia Coli.
Appearance
A sterile, colorless solution.

CEACAM8 Human

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 Human Recombinant

CEACAM8 Human, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain containing 292 amino acids (35-320 a.a) with a molecular mass of 32.3 kDa. It is fused to a 6 amino acid His-tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5092
Source

Sf9, Baculovirus cells.

Appearance
Sterile filtered colorless solution.
Definition and Classification

Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is part of a family of related glycoproteins known as the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs). CEA is primarily used as a tumor marker in clinical settings to monitor the treatment and progression of certain cancers, particularly colorectal cancer .

Biological Properties

CEA is a glycoprotein with a molecular weight of approximately 150-180 kDa. It is composed of a protein core and multiple carbohydrate chains. CEA is normally produced in gastrointestinal tissue during fetal development, but its production ceases before birth. In healthy adults, CEA levels are typically very low (about 2-4 ng/mL) . However, elevated levels can be found in certain cancers and non-cancerous conditions .

Biological Functions

CEA plays a role in cell adhesion, which is crucial for maintaining tissue architecture. It is also involved in immune responses and pathogen recognition. CEA can act as a ligand for selectins, which are cell adhesion molecules that play a role in the immune response and inflammation .

Modes of Action

CEA interacts with other molecules and cells through its glycosyl phosphatidyl inositol (GPI) anchor, which attaches it to the cell membrane. This interaction facilitates cell-cell adhesion and signaling. CEA can bind to other CEACAM family members and participate in homotypic binding, which is essential for its role in cell adhesion .

Regulatory Mechanisms

The expression and activity of CEA are regulated at multiple levels, including transcriptional regulation and post-translational modifications. The CEA gene family includes a promoter region that confers cell type-specific expression. Post-translational modifications, such as glycosylation, are crucial for the proper functioning of CEA .

Applications

CEA is widely used in biomedical research and clinical diagnostics. It serves as a tumor marker for monitoring the treatment and progression of cancers, particularly colorectal cancer. CEA levels are measured in blood tests to assess the effectiveness of cancer treatments and to detect recurrences . Additionally, CEA is being explored as a target for therapeutic strategies, including immunotherapy .

Role in the Life Cycle

CEA plays a significant role throughout the life cycle, from development to aging and disease. During fetal development, CEA is produced in gastrointestinal tissue. In adults, its levels are typically low but can increase in response to certain cancers and inflammatory conditions. Monitoring CEA levels can provide valuable insights into the progression of diseases and the effectiveness of treatments .

© Copyright 2024 Thebiotek. All Rights Reserved.