Recombinant Proteins

p53
LBP
CEA
HLA
TCL
TTC
NPM
MAF
Bax
BID

REG1A Human

Regenerating Islet-Derived 1 Alpha Human Recombinant

Recombinant Human REG 1 alpha is produced with an N-terminal His Tag. This fusion protein has a molecular weight of 17.8 kDa, consisting of 144 amino acid residues of Human REG 1 alpha and a 12 amino acid His Tag.
Shipped with Ice Packs
Cat. No.
BT11754
Source
Escherichia Coli.

REG1B Human

Regenerating Islet-Derived 1 Beta Human Recombinant

This product is a Recombinant Human REG 1 beta protein with an N-terminal His Tag. Produced in E. coli, the Human REG 1 beta His-Tagged Fusion Protein is 17.8 kDa and consists of 144 amino acid residues of the Human REG 1 beta and an additional 12 amino acid residues from the His Tag (underlined).
Shipped with Ice Packs
Cat. No.
BT11819
Source
Escherichia Coli.
Appearance
White lyophilized powder, filtered for purity.

REG3A Human

Regenerating Islet-Derived 3 Alpha Human Recombinant

This product consists of the human REG3A protein with a His tag attached to its N-terminal end. It has a molecular weight of 18.4 kDa and is composed of 149 amino acids from the REG3A protein and 16 amino acids from the His tag.
Shipped with Ice Packs
Cat. No.
BT11872
Source
Escherichia Coli.
Appearance
White powder, lyophilized and filtered.

REG4 Human

Regenerating Islet-Derived 4 Human Recombinant

Recombinant Human REG-4, with an N-terminal His Tag fusion, is a 17.4 kDa protein. It comprises 136 amino acid residues of Human REG 4 and a 12 amino acid His Tag (represented as underlined).
Shipped with Ice Packs
Cat. No.
BT11963
Source
Escherichia Coli.
Appearance
White lyophilized powder, filtered before lyophilization.

REG4 Human, Sf9

Regenerating Islet-Derived 4 Human Recombinant, Sf9

REG4, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain with a His Tag at the C-terminus. It comprises amino acids 23-158 of the REG4 sequence (total 145 amino acids) and has a molecular mass of 17kDa. On SDS-PAGE under reducing conditions, REG4 appears as multiple bands between 13.5-18kDa. It is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT12034
Source

Sf9, Baculovirus cells.

Appearance
Clear, colorless, and sterile-filtered solution.
Definition and Classification

Regenerating islet-derived (Reg) proteins are a family of small, secreted C-type lectins initially identified in the pancreas. They are involved in various physiological processes, including cell proliferation, differentiation, and tissue regeneration. The Reg family is classified into several subfamilies, such as Reg1, Reg2, Reg3, and Reg4, each with distinct members like Reg1A, Reg1B, Reg3A, and Reg4 .

Biological Properties

Key Biological Properties: Reg proteins exhibit pro-proliferative, anti-apoptotic, differentiation-inducing, and bactericidal properties .

Expression Patterns: These proteins are expressed in various tissues, including the pancreas, gastrointestinal tract, and liver. Their expression is often upregulated in response to injury, inflammation, and certain diseases .

Tissue Distribution: Reg proteins are predominantly found in the pancreas, particularly in the islets of Langerhans, but are also present in other tissues such as the gastrointestinal tract and liver .

Biological Functions

Primary Biological Functions: Reg proteins play crucial roles in tissue repair, cell proliferation, and apoptosis inhibition. They are also involved in antimicrobial defense and inflammation regulation .

Role in Immune Responses: Reg proteins contribute to immune responses by recognizing and binding to pathogens, thereby facilitating their clearance .

Pathogen Recognition: These proteins can bind to bacterial cell walls, enhancing the host’s ability to combat infections .

Modes of Action

Mechanisms with Other Molecules and Cells: Reg proteins interact with various receptors and signaling molecules to exert their effects. For example, Reg3A binds to bacterial peptidoglycan, leading to bacterial cell lysis .

Binding Partners: Reg proteins have several binding partners, including cell surface receptors and extracellular matrix components .

Downstream Signaling Cascades: Upon binding to their receptors, Reg proteins activate downstream signaling pathways such as the JAK-STAT, PI3K-Akt, and NF-κB pathways, which mediate their biological effects .

Regulatory Mechanisms

Regulation of Expression and Activity: The expression of Reg proteins is tightly regulated at the transcriptional and post-transcriptional levels. Factors such as cytokines, growth factors, and stress signals can modulate their expression .

Transcriptional Regulation: Transcription factors like STAT3 and NF-κB play significant roles in regulating the expression of Reg genes .

Post-Translational Modifications: Reg proteins undergo various post-translational modifications, including glycosylation and phosphorylation, which can affect their stability and activity .

Applications

Biomedical Research: Reg proteins are valuable tools in biomedical research for studying cell proliferation, differentiation, and tissue regeneration .

Diagnostic Tools: Due to their altered expression in various diseases, Reg proteins serve as potential biomarkers for conditions such as diabetes, cancer, and inflammatory diseases .

Therapeutic Strategies: Reg proteins hold promise as therapeutic agents for promoting tissue repair and regeneration in diseases like diabetes and inflammatory bowel disease .

Role in the Life Cycle

Development: Reg proteins are involved in the development and differentiation of various tissues, including the pancreas and gastrointestinal tract .

Aging: The expression of Reg proteins can change with age, potentially influencing tissue repair and regeneration processes .

Disease: Dysregulation of Reg protein expression is associated with several diseases, including diabetes, cancer, and neurodegenerative disorders .

© Copyright 2024 Thebiotek. All Rights Reserved.