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Recombinant Proteins

Centromere Protein

Calcium Binding Protein

Dynactin

Killer Cell Lectin-like Receptor

Other

Dynein Light Chain

SNRP

Kirsten Rat Sarcoma Viral Oncogene

Dysbindin

Kruppel-Like Factor

Ectodysplasin

Elongator Acetyltransferase Complex

Endothelial Cell-Specific Molecule 1

Endoplasmic Reticulum Protein

Solute Carrier Family

Lactoferrin

EPH Receptor

Sorting Nexin

Calcyphosine

Leukocyte Cell Derived Chemotaxin

RAN Binding Protein

Calmodulin

Outer Membrane Protein

Ephrin

p53

sRAGE

Leukocyte-Associated Ig-Like Receptor

Paired Box

Parkinson Disease Protein

SPSB

LIN Protein

Parvalbumin

PCNA

SPARC

PDZ Domain Containing

LBP

Calpain

Calponin

Pentraxin

SRY (Sex Determining Region Y)-Box

Calreticulin

Eukaryotic Translation Initiation Factor

Peroxisomal Biogenesis Factor

Listeriolysin

Stathmin

PHD Finger Protein

LRG1

Calumenin

Phosducin-Like

Streptavidin Proteins

Candida Albicans

Phosphatase and Tensin

Lymphocyte Antigen

PITPN

Canopy FGF Signaling Regulator

Lysosomal-Associated Membrane Protein

Phospholipid Scramblase

STIP

Capping Protein

PIH1 Domain Containing

Pim Oncogene

SDHAF

CEA

Polymerase (RNA) (DNA directed) Polypeptide

MAD2

Superoxide Dismutase

Mago-Nashi Homolog

HLA

KCTD

Caspase Recruitment Domain Family

CEBP

Surfeit

POU Class

Synaptobrevin

ERCC

CCR4-NOT Transcription Complex

Exosome Component

Maltose Binding Protein

Prefoldin

Cell Division Cycle

Mediator Complex

FABP

Melanoma Antigen Family A

Synaptosomal Associated Protein

Pregnancy Specific Beta-1-Glycoprotein

Cellular Retinoic Acid Binding Protein

Centrin

Synaptotagmin

Member RAS Oncogene Family

Prion Protein

Processing Of Precursor

Syndecan

Profilin

Charged Multivesicular Body Protein

Programmed Cell Death

Chloride Intracellular Channel

Family with Sequence Similarity

Chromatin Modifying Protein

Synovial Sarcoma, X Breakpoint

Chromobox

Prohibitin

Syntaxin

F-Box Protein

Proprotein Convertase Subtilisin/Kexin

Chromogranin

Protein C-Ets

Ferritin

Protein Phosphatase

Fibrinogen

Protein-A, A/G & G

Chromosome Open Reading Frame

Fibronectin Type III Domain Containing

Synuclein

Folate Receptor

Four And A Half LIM

Fragile Histidine Triad

G Antigen

GABA(A) Receptor-Associated Protein

Gastrokine

Tachykinin

TAR DNA

Clathrin

GDP Dissociation Inhibitor

Prothymosin

Coagulation Factors

General Transcription Factor

RAD51

TBC1 Domain Family

RASSF

TCL

Ras-Related C3 Botulinum Toxin Substrate

GIPC PDZ Domain

Cofilin

TTC

Gliadin

Mesoderm Development Candidate

Coiled-Coil Domain

Receptor Activity-Modifying Protein

Met Proto-Oncogene

Glycophorin

Toll Like Receptor

Methylmalonic Aciduria

Regenerating Islet-Derived

THAP Domain

MHC class I chain-related gene

Glycoprotein Nmb

Collagen

Thioredoxin

Glypican

Microfibrillar Associated Protein

Actin

Regulator of Calcineurin

Gremlin

Regulator of G-Protein Signaling

Microtubule-Associated Protein

GTPase IMAP Family

Adaptor-Related Protein Complex

GTP-Binding Protein

Guanine Nucleotide Binding Protein

ADP-Ribosylation Factor

Related RAS Viral (r-ras) Oncogene

COMM Domain Containing

TIGAR

Mitochondrial Ribosomal Protein

Relaxin

Hairy and Enhancer of Split

Tissue Factor Pathway Inhibitor

Renin

Complement Component

Haptoglobin

TNF receptor-Associated Factor

Mitochondrial Transcription Factor

Reticulocalbin

Trafficking Protein Particle Complex

Heat Shock Protein

MOB1, Mps One Binder Kinase Activator

Retinoblastoma

Mortality Factor

Myelin Basic Protein

Retinoic Acid Early Transcript

Myelin Oligodendrocyte Glycoprotein

Transcription Elongation Factor

Myoglobin

Ag85

Retinoic Acid Receptor Responder

Albumin

Myosin Light Chain

Rho Family GTPase

Transferrin

Rho GDP Dissociation Inhibitor

Allergy

Ribosomal Protein

Transforming Growth Factor Beta Induced

Transgelin

Myxovirus

Translocase Of Outer Mitochondrial Membrane

NANOG

Troponin

NCK Adaptor Protein

Junctional Adhesion Molecule

Nescient Helix Loop Helix

NECTIN

Neuronal Calcium Sensor

Neutrophil Cytosolic Factor

NFKB Inhibitor

Ring Finger Protein

Triggering Receptor Expressed on Myeloid Cells

NHP2

Tripartite Motif

Alpha-2-HS-Glycoprotein

RNA Binding Motif Protein

Tropomyosin

Anaplasma

COP9 Signalosome

N-Myc Downstream Regulated

R-Spondin

Ankyrin Repeat Domain

C-Reactive Protein

TROVE Domain Family

Non-Metastatic Cells

RWD Domain Containing

Sclerostin

Hematological And Neurological Expressed

Angiogenin

Hemoglobin

Annexin

Trypsin

Secretagogin

Crystallin

Tubulin Folding Cofactor

Secreted Frizzled-Related Protein

NTF2-like Export Factor

Nucleobindin

Hemopexin

U6 Small Nuclear RNA

NPM

HNRNP

Nucleopurin

Secretoglobin

Nucleosome Assembly Protein

High-Mobility Group

Secretogranin

Tubulin Gamma

Orosomucoid

Selectin

Ubiquinol-Cytochrome C Reductase

Anterior Gradient Protein

Ubiquitin

ASF1 Anti-Silencing Function 1

HINT

C-type Lectin Domain

ATP Synthase Mitochondrial

Homeobox

Selenoprotein

ATPase

Septin

Serglycin

Homer Homolog

Serine Peptidase Inhibitor

Autophagy Related

Hypoxia-Inducible Factor

Serpin

Bartonella H.

Ig Heavy Chain Constant Region

CUE Domain Containing

B Cell Lymphoma

Cystatin

UCHL1

IMPAD1

UL16 binding protein

Inhibitor of DNA Binding

Uroplakin

Inhibitor of Growth Family

Integrin

Vacuolar Protein Sorting

Intercellular Adhesion Molecule

Vascular cell adhesion molecule

B9 Protein

SERTA Domain Containing

Babesia Microti

SH2 Domain

V-crk Sarcoma Virus CT10

SH3 Domain

Baculoviral IAP Repeat-Containing

Vimentin

Karyopherin

Visinin-Like Protein

BATF

Cysteine-Rich

Killer Cell

Basic Transcription Factor

MAF

SIGLEC

Cysteine-Rich Secretory Protein

Bax

V-ral Simian Leukemia Viral Oncogene

Beta 2 Microglobulin

Cytochrome

WAP Four-Disulfide Core Domain

Signal Recognition Particle

BID

Y. Enterocolitica

Signal Sequence Receptor

Biglycan

Signal-Regulatory Protein

Cytohesin

Bromodomain Containing

Zinc Finger

Cadherin

Cytokeratin

Single-Stranded DNA Binding Protein

Sirtuin

Bridging Integrator

SIX Homeobox

Calbindin

SLAM Family

SMAD

DCUN1D

DEAD Box Protein

Decorin

Density Lipoprotein

Developmental Pluripotency Associated

Dickkopf-Related Protein

DiGeorge Syndrome Critical Region

DNA-Damage Protein

Transmembrane Proteins

FC Receptor

Cancer Targets

Immune Checkpoint

CAR-T Cell Therapy Targets

Product List

CENPB Human

Centromere Protein B Human Recombinant

This product consists of recombinant human CENPB protein produced in SF9 insect cells. It is glycosylated and has a molecular weight of 80 kDa. For purification and detection purposes, a 6x His tag is attached to the N-terminus. The protein is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT6942

Source

Sf9 insect cells.

Appearance

Sterile, filtered liquid.

View Details

CENPH Human

Centromere Protein-H Human Recombinant

Recombinantly produced in E.coli, CENPH Human is a single, non-glycosylated polypeptide chain. This 133 amino acid chain (136-247) has a molecular weight of 15.5 kDa. For purification, a 20 amino acid His-Tag is fused to the N-terminus, and proprietary chromatographic techniques are employed.

Shipped with Ice Packs

Cat. No.

BT7032

Source

E.coli.

Appearance

A clear, sterile solution.

View Details

CENPM Human

Centromere Protein-M Human Recombinant

CENPM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (1-180) and having a molecular mass of 22.0kDa. CENPM is fused to a 23 amino acid His-tag at the N-terminus and purified by proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7094

Source

Escherichia Coli.

Appearance

Sterile filtered colorless solution.

View Details

CENPP Human

Centromere Protein-P Human Recombinant

Recombinant human CENPP protein produced in E. coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (amino acids 1-288) and has a molecular mass of 35.3 kDa. CENPP is fused to a 20 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7213

Source

Escherichia Coli.

Appearance

A sterile, colorless solution.

View Details

CENPA Human

Centromere Protein A Human Recombinant

CENPA Human Recombinant, produced in SF9 cells, is a glycosylated polypeptide chain with a molecular weight of 17,015 Daltons. This protein is expressed with a -6x His tag and purified using proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT6814

Source

Sf9 insect cells.

Appearance

Clear, sterile liquid.

View Details

CENPQ Human

Centromere Protein-Q Human Recombinant

Recombinant CENPQ, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 291 amino acids (residues 1-268) with a molecular weight of 33 kDa. This protein includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7306

Source

Escherichia Coli.

Appearance

Clear, colorless solution, sterile-filtered.

View Details

CENPU Human

Centromere Protein-U Human Recombinant

Recombinant human CENPU, expressed in E. coli, is a single, non-glycosylated polypeptide chain. This protein consists of 295 amino acids (147-418a.a), resulting in a molecular mass of 33.7 kDa. The N-terminus of CENPU is fused to a 23 amino acid His-tag. Purification is achieved through proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7371

Source

Escherichia Coli.

Appearance

Clear, sterile-filtered solution.

View Details

Introduction

Definition and Classification

Centromere proteins are specialized proteins that play a crucial role in the function of the centromere, a region of the chromosome essential for accurate segregation during cell division. The centromere is the site where the kinetochore assembles, allowing chromosomes to attach to spindle fibers and ensuring proper distribution to daughter cells. Centromere proteins can be classified into various types based on their functions and interactions, including centromere protein A (CENP-A), CENP-B, CENP-C, and others.

Biological Properties

Centromere proteins exhibit several key biological properties:

Expression Patterns: Centromere proteins are expressed in a cell cycle-dependent manner, with peak expression during mitosis and meiosis.
Tissue Distribution: These proteins are ubiquitously present in all dividing cells, with higher concentrations in tissues with high mitotic activity, such as bone marrow and epithelial tissues.

Biological Functions

The primary biological functions of centromere proteins include:

Chromosome Segregation: Centromere proteins are essential for the proper segregation of chromosomes during cell division.
Immune Responses and Pathogen Recognition: While their primary role is in cell division, some centromere proteins have been implicated in immune responses and pathogen recognition.

Modes of Action

Centromere proteins interact with other molecules and cells through various mechanisms:

Binding Partners: Centromere proteins, such as CENP-A, replace histone H3 in the nucleosome, forming a unique chromatin structure that is recognized by other centromere proteins.
Downstream Signaling Cascades: These proteins recruit and interact with kinetochore proteins, facilitating the attachment of spindle microtubules and activating signaling pathways that ensure accurate chromosome segregation.

Regulatory Mechanisms

The expression and activity of centromere proteins are tightly regulated through several mechanisms:

Transcriptional Regulation: The transcription of centromere protein genes is controlled by cell cycle-dependent transcription factors.
Post-Translational Modifications: Centromere proteins undergo various post-translational modifications, such as phosphorylation and ubiquitination, which regulate their stability and function.

Applications

Centromere proteins have several applications in biomedical research and clinical practice:

Biomedical Research: Studying centromere proteins helps in understanding the mechanisms of chromosome segregation and the causes of chromosomal instability.
Diagnostic Tools: Antibodies against centromere proteins are used in diagnostic assays for certain autoimmune diseases.
Therapeutic Strategies: Targeting centromere proteins is being explored as a potential therapeutic strategy for cancer treatment.

Role in the Life Cycle

Centromere proteins play a vital role throughout the life cycle:

Development: They are essential for the proper segregation of chromosomes during embryonic development.
Aging and Disease: Dysregulation of centromere proteins can lead to chromosomal instability, contributing to aging and the development of diseases such as cancer.