Recombinant Proteins

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LBP
CEA
HLA
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BID

Product List

DLX3 Human

Distal-Less Homeobox 3 Human Recombinant

DLX3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids (1-186 a.a) and having a molecular mass of 23.4kDa.
DLX3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21646
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.

HHEX Human

Hematopoietically Expressed Homeobox Human Recombinant

HHEX Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 293 amino acids (1-270) and having a molecular mass of 32.4kDa.
HHEX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21730
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.

HOPX Human

HOP homeobox Human Recombinant

HOPX Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids (1-73 a.a) and having a molecular mass of 10.8kDa.
HOPX is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21801
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.

HOXA9 Human

Homeobox A9 Human Recombinant

HOXA9 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 295 amino acids (1-272) and having a molecular mass of 32.6 kDa.
HOXA9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21861
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

HOXB13 Human

Homeobox B13 Human Recombinant

HOXB13 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 307 amino acids (1-284 a.a) and having a molecular mass of 33.1kDa.
HOXB13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21943
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

HOXC11 Human

Homeobox C11 Human Recombinant

HOXC11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 327 amino acids (1-304 a.a.) and having a molecular mass of 36.1kDa. HOXC11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT22011
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

MEOX2 Human

Mesenchyme Homeobox 2 Human Recombinant

MEOX2 Human Recombinant produced in E. coli is a single polypeptide chain containing 140 amino acids (188-304) and having a molecular mass of 15.9kDa. MEOX2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT22103
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

NKX3-1 Human

NK3 Homeobox 1 Human Recombinant

NKX3-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 257 amino acids (1-234 a.a) and having a molecular mass of 28.7kDa.
NKX3-1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT22172
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.

PRRX1 Human

Paired Related Homeobox 1 Human Recombinant

PRRX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 241 amino acids (1-217 a.a) and having a molecular mass of 26.9kDa.
PRRX1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT22249
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

Introduction

Definition and Classification

A homeobox is a DNA sequence, approximately 180 base pairs long, that encodes a domain known as a homeodomain. This domain binds to specific DNA sequences and functions as a transcriptional regulator during development . Homeobox genes are classified into several classes and families based on their sequence similarities and functions. The most commonly recognized groupings include the ANTP, PRD, LIM, POU, HNF, SINE, TALE, CUT, PROS, and ZF groups .

Biological Properties

Key Biological Properties: Homeobox genes encode transcription factors that play crucial roles in regulating gene expression and cell differentiation during early embryonic development . They are involved in the regulation of patterns of anatomical development (morphogenesis) in animals, fungi, plants, and numerous single-cell eukaryotes .

Expression Patterns and Tissue Distribution: Homeobox genes are spatially and temporally expressed during early embryological development. Their expression patterns are highly conserved and shared across a wide array of living taxa . They are found in various tissues, including the nervous system, where they control the development of several cell types .

Biological Functions

Primary Biological Functions: Homeobox genes act as master control genes, meaning that a single protein can regulate the expression of many target genes . They are critical for regulating gene expression and controlling various aspects of morphogenesis and cell differentiation .

Role in Immune Responses and Pathogen Recognition: While homeobox genes are primarily known for their roles in development, some studies suggest they may also play roles in immune responses and pathogen recognition. However, this area requires further research to fully understand their involvement.

Modes of Action

Mechanisms with Other Molecules and Cells: Homeobox genes encode homeodomain proteins that function as transcription factors. These proteins bind to specific DNA sequences and regulate the expression of target genes . They interact with other transcription factors and co-regulators to form complexes that control gene expression .

Binding Partners and Downstream Signaling Cascades: Homeodomain proteins often form complexes with other proteins to regulate gene expression. These complexes can activate or repress the transcription of target genes, leading to downstream signaling cascades that control various developmental processes .

Regulatory Mechanisms

Transcriptional Regulation: Homeobox genes are regulated at the transcriptional level by various factors, including other transcription factors and signaling molecules . They contain cis-regulatory elements in their promoter regions that control their expression patterns .

Post-Translational Modifications: Homeodomain proteins can undergo post-translational modifications, such as phosphorylation, which can affect their stability, localization, and activity .

Applications

Biomedical Research: Homeobox genes are extensively studied in biomedical research due to their crucial roles in development and disease. They are used as markers to study developmental processes and to understand congenital abnormalities .

Diagnostic Tools and Therapeutic Strategies: Homeobox genes have potential applications in diagnostic tools and therapeutic strategies. For example, mutations in homeobox genes can serve as biomarkers for certain developmental disorders . Additionally, targeting homeobox genes or their pathways could provide new therapeutic approaches for treating diseases .

Role in the Life Cycle

Development: Homeobox genes play essential roles throughout the life cycle, from early embryonic development to adulthood. They regulate the formation of body segments, organs, and tissues .

Aging and Disease: Homeobox genes continue to be important in maintaining tissue homeostasis and function throughout life. Dysregulation of homeobox genes can lead to various diseases, including cancer and neurodegenerative disorders .

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