Recombinant Proteins

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C1Q Mouse

Complement Component C1q Mouse

Mouse Complement C1Q, with a molecular weight of 439.5 kDa, is produced in Mouse plasma.

Shipped with Ice Packs
Cat. No.
BT13952
Source

Mouse Plasma.

Appearance

The product is a sterile-filtered solution.

C1Q Rabbit

Complement Component C1q Rabbit

Rabbit Complement C1Q is a protein with a molecular weight of 417.6kDa, consisting of 18 polypeptide chains.
Shipped with Ice Packs
Cat. No.
BT14042
Source

Rabbit serum.

Appearance
The product is a sterile filtered solution.

C1Q Rat

Complement Component C1q Rat

Rat Complement C1Q is a 400 kDa protein produced from Rat plasma.

Shipped with Ice Packs
Cat. No.
BT14150
Source

Rat Plasma.

Appearance

The product is a sterile, filtered solution.

C1QBP Human

Complement Component 1 Human Recombinant

Recombinant human C1QBP, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 210 amino acids. It has a molecular weight of 23.9 kDa.
Shipped with Ice Packs
Cat. No.
BT14209
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

C1QTNF1 Human

Complement C1q Tumor Necrosis Factor-Related Protein 1 Human Recombinant

Recombinant human C1QTNF1, produced in E. coli, is a non-glycosylated polypeptide chain that consists of 266 amino acids. With a molecular weight of 30.45 kDa, it contains an additional His tag at the N-terminus. The amino acid sequence of this protein is identical to amino acids 26-281 of the UniProtKB/Swiss-Prot entry Q9BXJ1. Purification of C1QTNF1 is achieved through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT14277
Source
Escherichia Coli.

C2 Human

Complement C2 Human

Human Complement C2, derived from human plasma, has a molecular weight of 93 kDa.

Shipped with Ice Packs
Cat. No.
BT15327
Source

Human Plasma.

Appearance

This product is provided as a sterile filtered solution.

C3 Human

Complement C3 Human

Human Complement C3, derived from human plasma, has a molecular weight of 185 kDa.

Shipped with Ice Packs
Cat. No.
BT15389
Source

Human Plasma.

Appearance

The product is a sterile filtered solution.

C3 Mouse

Complement C3 Mouse

Murine Complement Component 3 (C3) derived from mouse plasma, exhibiting a molecular weight of 185 kDa.

Shipped with Ice Packs
Cat. No.
BT15465
Source

Mouse Plasma.

Appearance

A solution subjected to sterile filtration.

C3c Human

Complement Component C3c Human

Human C3c, a 137 KDa protein, is produced in human plasma. It comprises three disulfide-linked peptides: C3c Beta chain (amino acids 23-667), C3c alpha chain fragment 1 (amino acids 749-954), and C3c alpha chain fragment 2 (amino acids 1321-1663).
Shipped with Ice Packs
Cat. No.
BT16244
Source
Human Plasma.
Appearance
Sterile Filtered White lyophilized powder.

C3d Human

Complement C3d Human

Human Complement C3d, derived from human plasma, has a molecular weight of 33.8 kDa.

Shipped with Ice Packs
Cat. No.
BT16325
Source

Human Plasma.

Appearance

The product is provided as a sterile filtered solution.

Definition and Classification

The complement system is a crucial part of the immune system, consisting of over 20 proteins that circulate in the blood and tissue fluids. These proteins are typically inactive but become sequentially activated in response to the recognition of molecular components of microorganisms . The complement system can be classified into three main pathways: the classical pathway, the alternative pathway, and the lectin pathway .

Biological Properties

Complement components are serum proteins that cooperate with both the innate and adaptive immune systems to eliminate pathogens . They are primarily synthesized by liver cells, but also by macrophages and other cell types . These proteins are heat-labile and glycosylated . They are distributed in various tissues and are present in the sera of all mammals, including humans, birds, amphibians, and fishes .

Biological Functions

The primary functions of complement components include opsonization, chemotaxis, and lysis of pathogens . They play a significant role in immune responses by enhancing the ability of antibodies and phagocytic cells to clear microbes and damaged cells . Complement components also promote inflammation and attack the pathogen’s cell membrane .

Modes of Action

Complement activation occurs through three pathways: the classical pathway, the lectin pathway, and the alternative pathway . Each pathway involves a series of proteolytic cleavages that activate complement proteins, leading to the formation of enzyme complexes such as C3 and C5 convertases . These complexes facilitate the binding of complement proteins to pathogens, promoting their opsonization and lysis . The membrane attack complex (MAC) is formed, which creates pores in the pathogen’s membrane, leading to cell lysis .

Regulatory Mechanisms

The complement system is tightly regulated to prevent damage to host tissues . Regulatory proteins, such as complement control proteins, interact with complement components to distinguish between self and non-self cells . These regulatory mechanisms include transcriptional regulation and post-translational modifications that control the expression and activity of complement proteins .

Applications

Complement components have various applications in biomedical research, diagnostic tools, and therapeutic strategies . They are used to study immune responses and develop treatments for autoimmune diseases and infections . Complement proteins are also utilized in diagnostic assays to detect immune deficiencies and monitor disease progression .

Role in the Life Cycle

Throughout the life cycle, complement components play a vital role in maintaining immune homeostasis . They are involved in the clearance of apoptotic cells and immune complexes, which is essential for preventing autoimmune diseases . Complement activity is crucial from development to aging, as it helps protect against infections and supports tissue repair .

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