Recombinant Proteins
Product List
Adipsin Human
Complement Factor D Human Recombinant
Adipsin Human, Sf9
Complement Factor D Human Recombinant, Sf9
C1q Human
Complement Component C1q Human
C1q is a complex of two C1q sub-units and is a tetramer comprising of two C1r and two C1s sub-units.
C1q Human, Liquid
Complement Component C1q Human, Liquid
Human Complement Component C1q produced in Human plasma having a molecular mass of 410 kDa.
C1Q Mouse
Complement Component C1q Mouse
Mouse Complement C1Q produced in Mouse plasma having a molecular weight of 439.5kDa.
C1Q Rabbit
Complement Component C1q Rabbit
Rabbit Complement C1Q composed of 18 polypeptide chains having a molecular weight of 417.6kDa.
C1Q Rat
Complement Component C1q Rat
Rat Complement C1Q produced in Rat plasma having a molecular weight of 400kDa.
C1QBP Human
Complement Component 1 Human Recombinant
C1QTNF1 Human
Complement C1q Tumor Necrosis Factor-Related Protein 1 Human Recombinant
The C1QTNF1 is purified by proprietary chromatographic techniques.
C1QTNF2 Human
Complement C1q Tumor Necrosis Factor-Related Protein 2 Human Recombinant
His-tag.
Introduction
The complement system is a crucial part of the immune system, consisting of over 20 proteins that circulate in the blood and tissue fluids. These proteins are typically inactive but become sequentially activated in response to the recognition of molecular components of microorganisms . The complement system can be classified into three main pathways: the classical pathway, the alternative pathway, and the lectin pathway .
Complement components are serum proteins that cooperate with both the innate and adaptive immune systems to eliminate pathogens . They are primarily synthesized by liver cells, but also by macrophages and other cell types . These proteins are heat-labile and glycosylated . They are distributed in various tissues and are present in the sera of all mammals, including humans, birds, amphibians, and fishes .
The primary functions of complement components include opsonization, chemotaxis, and lysis of pathogens . They play a significant role in immune responses by enhancing the ability of antibodies and phagocytic cells to clear microbes and damaged cells . Complement components also promote inflammation and attack the pathogen’s cell membrane .
Complement activation occurs through three pathways: the classical pathway, the lectin pathway, and the alternative pathway . Each pathway involves a series of proteolytic cleavages that activate complement proteins, leading to the formation of enzyme complexes such as C3 and C5 convertases . These complexes facilitate the binding of complement proteins to pathogens, promoting their opsonization and lysis . The membrane attack complex (MAC) is formed, which creates pores in the pathogen’s membrane, leading to cell lysis .
The complement system is tightly regulated to prevent damage to host tissues . Regulatory proteins, such as complement control proteins, interact with complement components to distinguish between self and non-self cells . These regulatory mechanisms include transcriptional regulation and post-translational modifications that control the expression and activity of complement proteins .
Complement components have various applications in biomedical research, diagnostic tools, and therapeutic strategies . They are used to study immune responses and develop treatments for autoimmune diseases and infections . Complement proteins are also utilized in diagnostic assays to detect immune deficiencies and monitor disease progression .
Throughout the life cycle, complement components play a vital role in maintaining immune homeostasis . They are involved in the clearance of apoptotic cells and immune complexes, which is essential for preventing autoimmune diseases . Complement activity is crucial from development to aging, as it helps protect against infections and supports tissue repair .
