Recombinant Proteins
Product List
C5 Human
Complement C5 Human
This part specifies that the origin of the Human Complement C5 is human plasma and states its molecular weight, which is 190 kDa.
Human Plasma.
This describes the product's physical state as a solution that has been sterilized through filtration.
C1R Human
Complement C1r Human
Human Complement C1r is a protein with a molecular weight of 92 kDa. It is derived from human plasma.
Human Plasma.
The product is a clear, sterile-filtered liquid.
C1S Human
Complement C1s Human
Human Complement C1s, derived from human plasma, has a molecular weight of 86 kDa.
Human Plasma.
Presented as a sterile, filtered solution.
C3b Inactivated Mouse
Complement C3b Inactivated Mouse
C3b Mouse
Complement C3b Mouse
Mouse Complement C3b, with a molecular weight of 175kDa, is produced in a mouse plasma environment.
Mouse Plasma.
The product is a sterile-filtered solution.
C3b Rabbit
Complement C3b Rabbit
C3b Rat
Complement C3b Rat
Rat Complement C3b is a protein with a molecular weight of 175kDa, produced from Rat plasma.
Rat Plasma.
The product is a sterile, filtered solution.
C5a Protein
Complement C5a Human
This product contains human Complement C5a, a protein with a molecular weight of 10.4 kDa. It is produced using human plasma.
Human Plasma.
The product is a clear, sterile solution that has been passed through a filter to remove any bacteria.
C6 Human
Complement C6 Human
This describes the origin and molecular weight of the Human Complement C6 protein offered: It's derived from human plasma and has a molecular mass of 105 kDa.
Human Plasma.
This specifies the physical state of the product as a sterilized solution, free from particulate matter.
C9 Human
Complement C9 Human
Human Complement C9, derived from human plasma, is a glycosylated polypeptide with a molecular weight of 71 kDa.
Introduction
The complement system is a crucial part of the immune system, consisting of over 20 proteins that circulate in the blood and tissue fluids. These proteins are typically inactive but become sequentially activated in response to the recognition of molecular components of microorganisms . The complement system can be classified into three main pathways: the classical pathway, the alternative pathway, and the lectin pathway .
Complement components are serum proteins that cooperate with both the innate and adaptive immune systems to eliminate pathogens . They are primarily synthesized by liver cells, but also by macrophages and other cell types . These proteins are heat-labile and glycosylated . They are distributed in various tissues and are present in the sera of all mammals, including humans, birds, amphibians, and fishes .
The primary functions of complement components include opsonization, chemotaxis, and lysis of pathogens . They play a significant role in immune responses by enhancing the ability of antibodies and phagocytic cells to clear microbes and damaged cells . Complement components also promote inflammation and attack the pathogen’s cell membrane .
Complement activation occurs through three pathways: the classical pathway, the lectin pathway, and the alternative pathway . Each pathway involves a series of proteolytic cleavages that activate complement proteins, leading to the formation of enzyme complexes such as C3 and C5 convertases . These complexes facilitate the binding of complement proteins to pathogens, promoting their opsonization and lysis . The membrane attack complex (MAC) is formed, which creates pores in the pathogen’s membrane, leading to cell lysis .
The complement system is tightly regulated to prevent damage to host tissues . Regulatory proteins, such as complement control proteins, interact with complement components to distinguish between self and non-self cells . These regulatory mechanisms include transcriptional regulation and post-translational modifications that control the expression and activity of complement proteins .
Complement components have various applications in biomedical research, diagnostic tools, and therapeutic strategies . They are used to study immune responses and develop treatments for autoimmune diseases and infections . Complement proteins are also utilized in diagnostic assays to detect immune deficiencies and monitor disease progression .
Throughout the life cycle, complement components play a vital role in maintaining immune homeostasis . They are involved in the clearance of apoptotic cells and immune complexes, which is essential for preventing autoimmune diseases . Complement activity is crucial from development to aging, as it helps protect against infections and supports tissue repair .
