Recombinant Proteins
Product List
C7 Human
Complement C7 Human
This product consists of human complement component C7. It is derived from human plasma and possesses a molecular weight of 92.4 kDa.
Human Plasma.
This product is a sterile-filtered solution.
C8 Human
Complement C8 Human
Human Complement C8, derived from human plasma, is a glycosylated polypeptide comprised of three chains, with a combined molecular weight of 151kDa.
C8G Human
Complement Component 8, Gamma Human Recombinant
CFI Human
Complement Factor I Human
Human Complement Factor I, produced from human plasma, is a glycoprotein composed of two disulfide-linked chains. It has a molecular weight of 88kDa.
Human Plasma.
The product is a sterile-filtered solution.
CFP Human
Complement Factor Properdin Human Recombinant
CFP Human, Native
Complement Factor Properdin Human
SERPING1 Human, Native
Serpin Peptidase Inhibitor, Clade G Member 1 Human
C1QTNF2 Human
Complement C1q Tumor Necrosis Factor-Related Protein 2 Human Recombinant
C1QTNF3 Human
Complement C1q Tumor Necrosis Factor-Related Protein 3 Human Recombinant
C1QTNF4 Human
Complement C1q Tumor Necrosis Factor-Related Protein 4 Human Recombinant
Introduction
The complement system is a crucial part of the immune system, consisting of over 20 proteins that circulate in the blood and tissue fluids. These proteins are typically inactive but become sequentially activated in response to the recognition of molecular components of microorganisms . The complement system can be classified into three main pathways: the classical pathway, the alternative pathway, and the lectin pathway .
Complement components are serum proteins that cooperate with both the innate and adaptive immune systems to eliminate pathogens . They are primarily synthesized by liver cells, but also by macrophages and other cell types . These proteins are heat-labile and glycosylated . They are distributed in various tissues and are present in the sera of all mammals, including humans, birds, amphibians, and fishes .
The primary functions of complement components include opsonization, chemotaxis, and lysis of pathogens . They play a significant role in immune responses by enhancing the ability of antibodies and phagocytic cells to clear microbes and damaged cells . Complement components also promote inflammation and attack the pathogen’s cell membrane .
Complement activation occurs through three pathways: the classical pathway, the lectin pathway, and the alternative pathway . Each pathway involves a series of proteolytic cleavages that activate complement proteins, leading to the formation of enzyme complexes such as C3 and C5 convertases . These complexes facilitate the binding of complement proteins to pathogens, promoting their opsonization and lysis . The membrane attack complex (MAC) is formed, which creates pores in the pathogen’s membrane, leading to cell lysis .
The complement system is tightly regulated to prevent damage to host tissues . Regulatory proteins, such as complement control proteins, interact with complement components to distinguish between self and non-self cells . These regulatory mechanisms include transcriptional regulation and post-translational modifications that control the expression and activity of complement proteins .
Complement components have various applications in biomedical research, diagnostic tools, and therapeutic strategies . They are used to study immune responses and develop treatments for autoimmune diseases and infections . Complement proteins are also utilized in diagnostic assays to detect immune deficiencies and monitor disease progression .
Throughout the life cycle, complement components play a vital role in maintaining immune homeostasis . They are involved in the clearance of apoptotic cells and immune complexes, which is essential for preventing autoimmune diseases . Complement activity is crucial from development to aging, as it helps protect against infections and supports tissue repair .
