Recombinant Proteins

p53
LBP
CEA
HLA
TCL
TTC
NPM
MAF
Bax
BID

SLC51B Human

Solute Carrier Family 51 Beta Human Recombinant

Recombinant SLC51B protein, produced in E. coli, is available as a single, non-glycosylated polypeptide chain. This protein consists of 95 amino acids (spanning positions 57-128) and has a molecular weight of 10.7 kDa. For purification purposes, a 23 amino acid His-tag is fused to the N-terminus of the SLC51B protein, and proprietary chromatographic techniques are employed.
Shipped with Ice Packs
Cat. No.
BT1967
Source
Escherichia Coli.
Appearance
A clear solution that has undergone sterile filtration.

SLC3A2 Human

Solute Carrier Family 3 Member 2 Human Recombinant

Produced in Sf9 Baculovirus cells, SLC3A2 is a single, glycosylated polypeptide chain comprising 434 amino acids (206-630a.a.). It has a molecular weight of 47.9kDa, although its apparent size on SDS-PAGE may range from approximately 40-57kDa.
This protein is expressed with a C-terminal 6 amino acid His tag and purified using proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT1845
Source

Sf9, Baculovirus cells.

Appearance
A sterile, colorless solution.
Definition and Classification

The Solute Carrier (SLC) family is a large group of membrane transport proteins that facilitate the transport of a wide variety of substrates across cellular membranes. This family includes over 400 members organized into 66 families . SLC transporters are primarily involved in the uptake of small molecules, including nutrients and xenobiotics, into cells . They are classified based on their sequences, structural features, and biological functions .

Biological Properties

Key Biological Properties: SLC transporters are integral membrane proteins that contain multiple hydrophobic transmembrane alpha helices connected by hydrophilic intra- and extracellular loops . They can function as monomers or oligomers .

Expression Patterns and Tissue Distribution: SLC transporters are expressed in various tissues and cells, including the cell membrane, mitochondria, and other intracellular organelles . They are found in both prokaryotes and eukaryotes .

Biological Functions

Primary Biological Functions: SLC transporters are responsible for transporting a broad spectrum of substrates such as neurotransmitters, amino acids, lipids, ions, and drugs across cellular membranes . They play a crucial role in maintaining cellular homeostasis and metabolic processes .

Role in Immune Responses and Pathogen Recognition: Some SLC transporters are involved in immune responses by regulating the transport of essential nutrients and metabolites required for immune cell function . They also play a role in pathogen recognition by modulating the transport of molecules involved in immune signaling .

Modes of Action

Mechanisms with Other Molecules and Cells: SLC transporters function as facilitative transporters, allowing solutes to flow downhill with their electrochemical gradients, or as secondary active transporters, allowing solutes to flow uphill against their electrochemical gradient by coupling their transport to the movement of a second solute .

Binding Partners and Downstream Signaling Cascades: SLC transporters interact with various binding partners, including other transporters, receptors, and signaling molecules, to regulate their activity and downstream signaling pathways .

Regulatory Mechanisms

Regulatory Mechanisms: The expression and activity of SLC transporters are regulated by various mechanisms, including transcriptional regulation, post-translational modifications, and feedback inhibition . These regulatory mechanisms ensure the proper functioning of SLC transporters in response to cellular and environmental changes .

Applications

Biomedical Research: SLC transporters are attractive targets for drug discovery and development due to their role in transporting drugs and other therapeutic agents across cellular membranes . They are also used as biomarkers for various diseases and conditions .

Diagnostic Tools and Therapeutic Strategies: SLC transporters are used in diagnostic tools to detect and monitor diseases, such as cancer and metabolic disorders . They are also targeted in therapeutic strategies to modulate their activity and improve drug efficacy and safety .

Role in the Life Cycle

Role Throughout the Life Cycle: SLC transporters play a critical role throughout the life cycle, from development to aging and disease . They are involved in various developmental processes, including cell differentiation and organogenesis . Dysregulation of SLC transporters can lead to various diseases, including neurological disorders, metabolic disorders, and cancer .

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