Recombinant Proteins

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LRG1 Canine

Leucine-Rich Alpha-2-Glycoprotein 1 Canine

Derived from pooled Canine Serum, the Canine LRG1 protein exhibits a molecular mass of 38.129 kDa (excluding glycosylation) and comprises 347 amino acid residues.
Shipped with Ice Packs
Cat. No.
BT3555
Source
Canine Serum.
Appearance
The product appears as a white, lyophilized powder after filtration.

LRG1 Human

Leucine-Rich Alpha-2-Glycoprotein 1 Human Recombinant

Recombinant human LRG1, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 335 amino acids (residues 36-347). It has a molecular weight of 36 kDa. The protein is engineered with a 23-amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT3634
Source
Escherichia Coli.
Appearance
The product appears as a sterile, colorless solution that has been filtered for sterility.

LRG1 Protein

Leucine-Rich Alpha-2-Glycoprotein 1 Human

Derived from human pooled serum, the Human LRG1 protein exhibits a molecular mass of 34.35kDa (excluding glycosylation) and comprises 312 amino acid residues.
Shipped with Ice Packs
Cat. No.
BT3695
Source
Human pooled serum.

LRG1 Human, Sf9

Leucine-Rich Alpha-2-Glycoprotein 1 Human Recombinant, Sf9

Recombinant LRG1, expressed in Sf9 insect cells using a baculovirus system, is a single, glycosylated polypeptide chain consisting of 321 amino acids (residues 36-347). With a molecular weight of 35.4 kDa, this protein is engineered with a 6-amino acid Histidine tag at the C-terminus to facilitate purification via proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT3745
Source
Sf9, Baculovirus cells.
Appearance
Sterile Filtered colorless solution.
Definition and Classification

Leucine-rich alpha-2-glycoprotein 1 (LRG1) is a secreted glycoprotein that belongs to the family of leucine-rich repeat (LRR) proteins. It was first discovered in human serum in 1977 . The LRR motifs are evolutionarily conserved and have been found in plants, animals, bacteria, and fungi . LRG1 is encoded by the LRG1 gene located on chromosome 19 in humans .

Biological Properties

Key Biological Properties: LRG1 is a secreted glycoprotein involved in various biological processes, including protein-protein interactions, signal transduction, and cell adhesion .

Expression Patterns: LRG1 is constitutively expressed by hepatocytes and neutrophils . It is also expressed during granulocyte differentiation .

Tissue Distribution: LRG1 is found in various tissues, including the liver, blood, bone marrow, and adipose tissues . It is also present in the extracellular space and specific granule lumen .

Biological Functions

Primary Biological Functions: LRG1 plays a crucial role in angiogenesis, the process of new blood vessel formation . It promotes neovascularization by modulating the transforming growth factor-beta (TGF-β) signaling pathway .

Role in Immune Responses and Pathogen Recognition: LRG1 is involved in innate immunity and the preservation of tissue integrity . It is induced in response to various inflammatory stimuli and contributes to disease pathogenesis .

Modes of Action

Mechanisms with Other Molecules and Cells: LRG1 interacts with the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway . It also modulates the TGF-β signaling pathway in a context-dependent manner .

Binding Partners and Downstream Signaling Cascades: LRG1 binds to transforming growth factor-beta receptor and other molecules involved in endothelial cell proliferation and angiogenesis . It affects various cell types, including epithelial, immune, mesenchymal, and cancer cells .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: LRG1 expression is regulated by various non-coding RNAs, including lncRNA TUG1, which facilitates LRG1 transcription . MicroRNAs such as miR-335, miR-494, miR-497, miR-150-5p, and miR-24-3p promote the degradation of LRG1 mRNA .

Transcriptional Regulation and Post-Translational Modifications: The transcriptional regulation of LRG1 involves various signaling pathways, including the TGF-β pathway . Post-translational modifications of LRG1 are not well-documented and require further research.

Applications

Biomedical Research: LRG1 is a potential biomarker for the diagnosis, prognosis, and monitoring of multiple conditions, including cancer, diabetes, cardiovascular disease, and inflammatory disorders .

Diagnostic Tools: Elevated levels of LRG1 in acute appendicitis and various cancers suggest its use as a diagnostic aid .

Therapeutic Strategies: LRG1 is a potential therapeutic target for diseases characterized by aberrant neovascularization . Inhibition of LRG1 has been shown to normalize tumor vasculature and improve the efficacy of cytotoxic and immune therapies .

Role in the Life Cycle

Role Throughout the Life Cycle: LRG1 is involved in various stages of the life cycle, from development to aging and disease . It plays a role in tissue integrity and immune responses, contributing to the preservation of homeostasis . In pathological conditions, LRG1 expression is upregulated, leading to disease progression .

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