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Recombinant Proteins
Product List
CHMP2B Human
Chromatin Modifying Protein 2B Human Recombinant
Recombinant human CHMP2B, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 233 amino acids (1-213) with a molecular weight of 26.1 kDa. This protein is fused to a 20 amino acid His-Tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs 
Cat. No.
BT8052
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
CHMP4A Human
Chromatin Modifying Protein 4A Human Recombinant
Recombinant human CHMP4A, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 285 amino acids (residues 1-265). It has a molecular mass of 32.0 kDa. The protein is fused to a 20 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8135
Source
E.coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
CHMP1A Human
Chromatin Modifying Protein 1A Human Recombinant
Recombinant human CHMP1A, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 219 amino acids (1-196 a.a.) with a molecular mass of 24.1 kDa. Note: The molecular size on SDS-PAGE might appear higher. This CHMP1A protein is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7908
Source
Escherichia Coli.
Appearance
A sterile, filtered solution that is colorless.
CHMP2A Human
Chromatin Modifying Protein 2A Human Recombinant
Recombinant human CHMP2A, with a 20 amino acid His tag at the N-terminus, is produced in E. coli. This protein is a single, non-glycosylated polypeptide chain consisting of 242 amino acids (amino acids 1-222) and has a molecular weight of 27.2 kDa. Purification of CHMP2A is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7972
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterile filtered.
Introduction
Definition and Classification
Chromatin modifying proteins are a diverse group of enzymes and proteins that alter the structure and function of chromatin, which is a complex of DNA and proteins found in the nucleus of eukaryotic cells. These modifications can include the addition or removal of chemical groups to histone proteins or DNA, leading to changes in gene expression. Chromatin modifying proteins can be classified into several categories based on their function:
- Writers: Enzymes that add chemical groups to histones or DNA, such as histone acetyltransferases (HATs) and DNA methyltransferases (DNMTs).
- Erasers: Enzymes that remove chemical groups, such as histone deacetylases (HDACs) and demethylases.
- Readers: Proteins that recognize and bind to specific histone or DNA modifications, influencing chromatin structure and gene expression .
Biological Properties
Chromatin modifying proteins exhibit key biological properties, including:
- Expression Patterns: These proteins are expressed in a tissue-specific manner, with different types and levels of expression depending on the cell type and developmental stage .
- Tissue Distribution: Chromatin modifying proteins are found in various tissues throughout the body, with some being more prevalent in specific tissues, such as the brain, liver, and immune cells .
Biological Functions
The primary biological functions of chromatin modifying proteins include:
- Gene Regulation: They play a crucial role in regulating gene expression by modifying chromatin structure, making it more or less accessible to transcription factors and other regulatory proteins .
- Immune Responses: Chromatin modifying proteins are involved in the regulation of immune responses by modulating the expression of genes related to pathogen recognition and immune cell activation .
- Pathogen Recognition: These proteins help in the recognition of pathogens by altering the expression of genes involved in the immune response .
Modes of Action
Chromatin modifying proteins interact with other molecules and cells through various mechanisms:
- Binding Partners: They often form complexes with other proteins, such as transcription factors, to regulate gene expression .
- Downstream Signaling Cascades: Chromatin modifications can trigger downstream signaling cascades that influence cellular processes such as differentiation, proliferation, and apoptosis .
Regulatory Mechanisms
The expression and activity of chromatin modifying proteins are tightly regulated through several mechanisms:
- Transcriptional Regulation: The expression of these proteins is controlled at the transcriptional level by various transcription factors and regulatory elements .
- Post-Translational Modifications: Chromatin modifying proteins themselves can be modified post-translationally, affecting their activity, stability, and interactions with other proteins .
Applications
Chromatin modifying proteins have several applications in biomedical research and clinical settings:
- Biomedical Research: They are used to study gene regulation, epigenetics, and the mechanisms underlying various diseases .
- Diagnostic Tools: Chromatin modifications can serve as biomarkers for the diagnosis of diseases such as cancer .
- Therapeutic Strategies: Targeting chromatin modifying proteins with small molecules or other therapeutic agents is a promising strategy for treating diseases, including cancer and neurodegenerative disorders .
Role in the Life Cycle
Chromatin modifying proteins play essential roles throughout the life cycle, from development to aging and disease:
- Development: They are crucial for proper development by regulating the expression of genes involved in cell differentiation and organogenesis .
- Aging: Changes in chromatin modifications are associated with aging and age-related diseases .
- Disease: Dysregulation of chromatin modifying proteins can lead to various diseases, including cancer, neurodegenerative disorders, and immune-related conditions .
