Recombinant Proteins
Product List
Vimentin Human
Vimentin Human Recombinant
Vimentin Bovine
Bovine Vimentin
Introduction
Key Biological Properties: Vimentin plays a significant role in maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions . It is involved in various cellular processes, including cell migration, cell shape, and organelle anchorage .
Expression Patterns: Vimentin is widely expressed in mesenchymal cells and is also found in endothelial cells, fibroblasts, and certain types of epithelial cells . It is highly dynamic and can be found in different cellular locations, including the cytoplasm and cell surface .
Tissue Distribution: Vimentin is expressed in various tissues, including the endothelial cells of lymphatic vessels, dermis, and stroma of bone marrow . It is also present in the ventricular zone, descending thoracic aorta, and synovial membrane .
Primary Biological Functions: Vimentin is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions . It plays a role in cell migration, cell shape, and plasticity .
Role in Immune Responses and Pathogen Recognition: Vimentin is involved in immune responses by regulating leukocyte migration and cell attachment to vascular endothelium . It also participates in pathogen recognition and immune-inflammatory responses .
Mechanisms with Other Molecules and Cells: Vimentin interacts with various molecules and cells, including integrins and adhesion receptors . It regulates cell adhesion by interacting with and regulating integrin function .
Binding Partners and Downstream Signaling Cascades: Vimentin binds to cytoplasmic domains of adhesion receptors such as integrins, promoting the association with the extracellular matrix (ECM) . It also regulates downstream signaling cascades involved in cell migration and adhesion .
Regulatory Mechanisms Controlling Expression and Activity: Vimentin expression is regulated at both the transcriptional and post-transcriptional levels . Post-transcriptional regulation involves microRNAs (miRNAs) and other regulatory molecules .
Transcriptional Regulation and Post-Translational Modifications: Vimentin undergoes various post-translational modifications, including phosphorylation, which affects its function and interaction with other proteins . These modifications play a crucial role in regulating vimentin’s activity and stability .
Biomedical Research: Vimentin is widely used as a marker for mesenchymal cells in biomedical research . It is also used to study cell migration, cell shape, and cytoskeletal dynamics .
Diagnostic Tools: Vimentin is used as a diagnostic marker for certain types of cancers, including prostate cancer, gastrointestinal tumors, and breast cancer . It helps in distinguishing between different types of tumors and understanding their progression .
Therapeutic Strategies: Vimentin is a potential therapeutic target for cancer treatment . Various strategies, including antibodies, nanobodies, and miRNAs, are being explored to inhibit vimentin’s pro-tumorigenic effects .
Role Throughout the Life Cycle: Vimentin plays a crucial role throughout the life cycle, from development to aging and disease . It is involved in various processes, including cell migration, cell shape, and organelle anchorage .
Development to Aging and Disease: Vimentin’s expression and function are regulated during development, and its dysregulation is associated with various diseases, including cancer, cataracts, Crohn’s disease, and rheumatoid arthritis . It also plays a role in viral infections by facilitating virus invasion and replication .
