Recombinant Proteins

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RPL30 Human

Ribosomal Protein L30 Human Recombinant

This product consists of a recombinant human RPL30 protein produced in E. coli. This single, non-glycosylated polypeptide chain comprises 138 amino acids, including amino acids 1 to 115 of the RPL30 sequence and a 23 amino acid His-tag located at the N-terminus. The molecular weight of the protein is 15.2 kDa. The purification process involves proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT16221
Source
Escherichia Coli.
Appearance
The product appears as a clear solution that has been sterilized through filtration.

RPL31 Human

Ribosomal Protein L31 Human Recombinant

Recombinant human RPL31, expressed in E. coli, is a single, non-glycosylated polypeptide chain. This protein encompasses 148 amino acids (specifically, residues 1 to 125) and exhibits a molecular weight of 16.9 kDa. For purification purposes, a 23-amino acid His-tag is fused to the N-terminus, and the protein is subsequently purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT16312
Source
Escherichia Coli.
Appearance
A clear solution that has undergone sterile filtration.

RPL34 Human

Ribosomal Protein L34 Human Recombinant

Recombinant human RPL34, expressed in E. coli, is a single, non-glycosylated polypeptide chain with a molecular weight of 15.7 kDa. The protein consists of 140 amino acids, with amino acids 1-117 corresponding to the RPL34 sequence. A 23 amino acid His-tag is fused to the N-terminus to facilitate purification. The protein has been purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT16421
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.

RPL35 Human

Ribosomal Protein L35 Human Recombinant

Recombinant RPL35 from humans, expressed in E. coli, is available as a single, non-glycosylated polypeptide chain. It consists of 146 amino acids (specifically, amino acids 1 through 123) and has a molecular weight of 16.9 kDa. This protein includes a 23-amino acid His-tag fused to its N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16505
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.

RPS6KB1 Human

Ribosomal Protein S6 Kinase B1 Human Recombinant

Produced using Sf9 insect cells, our RPS6KB1 is a single, glycosylated polypeptide chain that contains 533 amino acids (specifically amino acids 1 through 525). This protein has a molecular weight of 60.2 kDa. Note: On SDS-PAGE, the molecular size will appear between 70-100 kDa. This RPS6KB1 protein features an 8 amino acid His tag located at the C-terminus. Purification is achieved through proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT15690
Source

Sf9, Baculovirus cells.

Appearance
This product appears as a clear, colorless solution that has been sterilized by filtration.

RPL11 Human

Ribosomal Protein L11 Human Recombinant

Recombinant human RPL11, expressed in E.coli, is a single, non-glycosylated polypeptide chain. It comprises 201 amino acids, including a 23 amino acid His-tag at the N-terminus, and has a molecular weight of 22.6kDa. The purification process involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15758
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized through filtration.

RPL12 Human

Ribosomal Protein L12 Human Recombinant

Recombinant Human RPL12, produced in E. coli, is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-165 a.a), including a 23 amino acid His-tag at the N-terminus. It has a molecular mass of 20.2 kDa and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15858
Source
E.coli.
Appearance
Clear, colorless, and sterile-filtered solution.

RPL18A Human

Ribosomal Protein L18A Human Recombinant

Recombinant Human RPL18A, produced in E. coli, is a single, non-glycosylated polypeptide chain containing 199 amino acids (residues 1-176) with a molecular weight of 23.2 kDa. It is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15928
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized by filtration.

RPL22 Human

Ribosomal Protein L22 Human Recombinant

Recombinant human RPL22, expressed in E.coli, is a single, non-glycosylated polypeptide chain consisting of 151 amino acids (residues 1-128). It has a molecular weight of 17.0 kDa. The protein is engineered with a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16005
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized by filtration.

RPL23A Human

Ribosomal Protein L23A Human Recombinant

Recombinant Human RPL23A, expressed in E.Coli, is a single, non-glycosylated polypeptide chain with a molecular weight of 20.1kDa. It consists of 179 amino acids, spanning from positions 1 to 156.
The protein is engineered with a 23 amino acid His-tag fused at its N-terminus to facilitate purification, which is carried out using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT16072
Source
Escherichia Coli.
Appearance
The product appears as a clear solution that has undergone sterile filtration.
Definition and Classification

Ribosomal proteins are essential components of ribosomes, the molecular machines responsible for protein synthesis in all living cells. They work in conjunction with ribosomal RNA (rRNA) to form the two subunits of the ribosome: the small subunit and the large subunit. In prokaryotes, these subunits are referred to as 30S (small) and 50S (large), while in eukaryotes, they are 40S (small) and 60S (large) . Ribosomal proteins are highly conserved across different species, reflecting their fundamental role in cellular biology .

Biological Properties

Ribosomal proteins exhibit several key biological properties:

  • Expression Patterns: Ribosomal proteins are ubiquitously expressed in all cell types, given their essential role in protein synthesis .
  • Tissue Distribution: They are found in all tissues, with particularly high concentrations in rapidly dividing cells and tissues with high protein synthesis demands, such as the liver and bone marrow .
Biological Functions

The primary function of ribosomal proteins is to facilitate the assembly and function of ribosomes in protein synthesis. They play crucial roles in:

  • Immune Responses: Some ribosomal proteins are involved in the immune response by recognizing and binding to pathogen-associated molecular patterns (PAMPs) .
  • Pathogen Recognition: Certain ribosomal proteins can directly interact with viral RNA, aiding in the immune response against viral infections .
Modes of Action

Ribosomal proteins interact with various molecules and cells through several mechanisms:

  • Binding Partners: They bind to rRNA and other ribosomal proteins to form the ribosome’s structural framework .
  • Downstream Signaling Cascades: Ribosomal proteins can influence downstream signaling pathways by interacting with other cellular proteins, thereby affecting processes such as cell growth and apoptosis .
Regulatory Mechanisms

The expression and activity of ribosomal proteins are tightly regulated through:

  • Transcriptional Regulation: Ribosomal protein genes are regulated by transcription factors that respond to cellular growth conditions and stress .
  • Post-Translational Modifications: Ribosomal proteins undergo various post-translational modifications, such as phosphorylation and ubiquitination, which can affect their function and stability .
Applications

Ribosomal proteins have several applications in biomedical research and clinical practice:

  • Diagnostic Tools: Abnormal levels of ribosomal proteins can serve as biomarkers for certain diseases, including cancers .
  • Therapeutic Strategies: Ribosomal proteins are being explored as potential targets for new therapeutic interventions, particularly in cancer treatment .
Role in the Life Cycle

Ribosomal proteins play vital roles throughout the life cycle:

  • Development: They are crucial for the rapid cell division and growth that occurs during embryonic development .
  • Aging and Disease: Changes in ribosomal protein function and expression are associated with aging and various diseases, including neurodegenerative disorders and cancers .
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