Recombinant Proteins
Product List
VPS24 Human
Vacuolar Protein Sorting 24 Human Recombinant
VPS4B Human
Vacuolar Protein Sorting 4 Homolog B Human Recombinant
VPS25 Human
Vacuolar Protein Sorting 25 Human Recombinant
VPS26A Human
Vacuolar Protein Sorting 26A Human Recombinant
VPS28 Human
Vacuolar Protein Sorting 28 Human Recombinant
VPS29 Human
Vacuolar Protein Sorting 29 Human Recombinant
VPS29 Mouse
Vacuolar Protein Sorting 29 Mouse Recombinant
Introduction
Vacuolar Protein Sorting (VPS) refers to the cellular processes involved in the sorting and delivery of proteins to the vacuole, an essential organelle in eukaryotic cells. VPS proteins are crucial for the intracellular sorting and delivery of soluble vacuolar proteins . These proteins are classified based on their roles in different stages of the sorting pathway, including recognition, transport, and delivery to the vacuole .
Key Biological Properties: VPS proteins are evolutionarily conserved across species and play critical roles in intracellular sorting, membrane bending, transportation, and subcellular localization of proteins .
Expression Patterns and Tissue Distribution: VPS proteins are ubiquitously expressed in various tissues, with specific expression patterns depending on the organism and cell type . For example, in plants, vacuoles can occupy up to 90% of a cell’s total volume and are involved in various functions, including storage and detoxification .
Primary Biological Functions: VPS proteins are involved in the intracellular sorting and delivery of soluble vacuolar proteins . They play a crucial role in maintaining cellular homeostasis by regulating the transport of proteins to the vacuole, where they can be stored, degraded, or processed .
Role in Immune Responses and Pathogen Recognition: VPS proteins are also implicated in immune responses and pathogen recognition. For instance, they are involved in the trafficking of proteins that play a role in immune signaling pathways .
Mechanisms with Other Molecules and Cells: VPS proteins interact with various molecules and cellular components to facilitate protein sorting. This involves recognition of specific signal sequences by sorting receptors, which then direct the proteins to the vacuole .
Binding Partners and Downstream Signaling Cascades: VPS proteins often interact with other proteins, such as sorting receptors and accessory proteins, to mediate their functions. These interactions can trigger downstream signaling cascades that regulate various cellular processes .
Regulatory Mechanisms: The expression and activity of VPS proteins are tightly regulated at multiple levels. This includes transcriptional regulation, where specific genes are activated or repressed in response to cellular signals .
Post-Translational Modifications: VPS proteins can undergo various post-translational modifications, such as phosphorylation and ubiquitination, which can modulate their activity and stability .
Biomedical Research: VPS proteins are valuable tools in biomedical research for studying intracellular trafficking and protein sorting mechanisms .
Diagnostic Tools and Therapeutic Strategies: Understanding VPS pathways can lead to the development of diagnostic tools and therapeutic strategies for diseases related to protein misfolding and trafficking .
Role Throughout the Life Cycle: VPS proteins play essential roles throughout the life cycle of an organism. They are involved in various developmental processes, from embryogenesis to aging . In plants, for example, vacuoles are crucial for growth and development, as well as responses to environmental stress .
