Recombinant Proteins

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FABP1 Human

Fatty Acid Binding Protein-1 Human Recombinant

Recombinant human FABP1, expressed in E. coli, is a single, non-glycosylated polypeptide chain comprising 127 amino acids. It has a molecular weight of 14.2 kDa, as determined by its amino acid sequence.
Shipped with Ice Packs
Cat. No.
BT6018
Source
Escherichia Coli.
Appearance
White lyophilized powder that has been filtered.

FABP1 Human, His

Fatty Acid Binding Protein-1 Human Recombinant, His Tag

Recombinant human FABP1, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 147 amino acids in total (specifically, amino acids 1 to 127), resulting in a molecular weight of 16 kDa. A 20 amino acid His-Tag is fused to the N-terminus of the protein. The purification of FABP-1 is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT6057
Source
Escherichia Coli.
Appearance
The product appears as a clear, colorless solution that has been sterilized through filtration.

FABP1 Mouse

Fatty Acid Binding Protein-1 Mouse Recombinant

E. coli is used to produce recombinant mouse Fatty Acid Binding Protein-1, a single, non-glycosylated polypeptide chain with 127 amino acids and a molecular weight of 14.2 kDa. The FABP1 is purified using patented chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT6114
Source
Escherichia Coli.
Appearance
White lyophilized (freeze-dried) powder that has been sterile filtered.

FABP4 Protein

Fatty Acid Binding Protein 4 Human Recombinant

This protein consists of 132 amino acid residues and has a molecular weight of 14.7 kDa.
Shipped with Ice Packs
Cat. No.
BT6944
Source
Escherichia Coli.
Appearance
This product is supplied as a sterile filtered white powder that has been lyophilized (freeze-dried).

FABP5 Human

Epidermal Fatty Acid Binding Protein Human Recombinant

Recombinant Human Epidermal Fatty Acid Binding Protein (FABP-5) is a single-chain, non-glycosylated polypeptide consisting of 135 amino acids. It has a molecular weight of 15.2 kDa.
Shipped with Ice Packs
Cat. No.
BT7038
Source
Escherichia Coli.
Appearance
Lyophilized powder, sterile-filtered.

FABP5 Human, His

Fatty Acid Binding Protein 5 Human Recombinant, His Tag

Recombinant Human FABP5, with a His tag, is produced in E. coli. It is a single, non-glycosylated polypeptide chain comprising 135 amino acids. This protein has a molecular weight of 19.66 kDa. The His tag is fused to the N-terminus of FABP5. Purification is achieved using standard chromatography methods.
Shipped with Ice Packs
Cat. No.
BT7125
Source
Escherichia Coli.
Appearance
A sterile, colorless liquid solution.

FABP6 Human

Fatty Acid Binding Protein-6 Human Recombinant

Recombinant human FABP6, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 128 amino acids with a molecular weight of 14 kDa.
Shipped with Ice Packs
Cat. No.
BT7215
Source
Escherichia Coli.
Appearance
The product is a clear and colorless sterile filtered solution.

FABP6 Human, His

Fatty Acid Binding Protein 6 Human Recombinant, His Tag

Recombinant Human FABP6, expressed in E. coli, is a single, non-glycosylated polypeptide chain with a molecular weight of 18 kDa. This protein comprises 128 amino acids and has a His tag fused at its N-terminus. It is purified using standard chromatography techniques.
Shipped with Ice Packs
Cat. No.
BT7305
Source
Escherichia Coli.
Appearance
Sterile, colorless liquid.

FABP3 Human

Fatty Acid Binding Protein-3 Human Recombinant

FABP3 Human Recombinant is a polypeptide chain made in E. coli bacteria. It is not glycosylated, meaning it doesn't have sugars attached. The protein is purified using standard chromatography methods.
Shipped with Ice Packs
Cat. No.
BT6583
Source
Escherichia Coli.
Appearance
Clear, sterile liquid.

FABP3 Human, His

Fatty Acid Binding Protein 3 Human Recombinant, His Tag

Recombinant human FABP3, expressed in E. coli, is a non-glycosylated polypeptide chain with 133 amino acids. This protein, with a molecular weight of 19.1 kDa, includes a 37 amino acid His tag at the N-terminus and undergoes purification using standard chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT6672
Source
Escherichia Coli.
Appearance
Sterile, colorless liquid.
Definition and Classification

Fatty acid-binding proteins (FABPs) are a family of low-molecular-weight intracellular proteins that bind to hydrophobic ligands, primarily fatty acids. These proteins play a crucial role in the transport and metabolism of fatty acids within cells . FABPs are classified into several types based on their tissue-specific expression, including liver (L-FABP), intestine (I-FABP), heart (H-FABP), adipocyte (A-FABP), epidermal (E-FABP), ileal (Il-FABP), brain (B-FABP), myelin (M-FABP), and testis (T-FABP) .

Biological Properties

FABPs are small, structurally conserved cytosolic proteins with a water-filled interior-binding pocket surrounded by ten anti-parallel beta sheets, forming a beta barrel . They are ubiquitously expressed in tissues that are highly active in fatty acid metabolism, such as the liver, intestine, heart, adipose tissue, and brain . The expression patterns of FABPs are tissue-specific, with each type predominantly expressed in certain tissues but not exclusively limited to them .

Biological Functions

The primary function of FABPs is to bind fatty acids and facilitate their transport within cells . They enhance the solubility of hydrophobic fatty acids, allowing their efficient transport within the aqueous cytoplasm . FABPs also play a role in immune responses and pathogen recognition by modulating lipid-mediated signaling pathways . They are involved in various cellular processes, including signal transduction, lipid droplet storage, trafficking, membrane synthesis, and lipid-mediated transcriptional regulation .

Modes of Action

FABPs function as cytoplasmic lipid chaperones, facilitating fatty acid solubilization, trafficking, and metabolism . They interact with various membrane and intracellular proteins, such as peroxisome proliferator-activated receptors (PPARs) and hormone-sensitive lipase (HSL), to regulate tissue and cellular-specific lipid responses . By transporting fatty acids to the nucleus, FABPs can modulate the activity of nuclear receptors involved in transcriptional regulation .

Regulatory Mechanisms

The expression and activity of FABPs are regulated by various mechanisms, including transcriptional regulation and post-translational modifications . For example, the expression of FABP1 is regulated by PPAR isoforms, with PPARα and PPARβ agonists inhibiting its expression, while PPARγ agonists increase its expression . Post-translational modifications, such as phosphorylation, can also influence the activity and function of FABPs .

Applications

FABPs have several applications in biomedical research, diagnostic tools, and therapeutic strategies . They serve as biomarkers for disease diagnosis and prognosis, particularly in cardiovascular diseases where elevated levels of heart-type FABP (H-FABP) in blood plasma are associated with acute myocardial infarction . FABPs are also being explored as potential therapeutic targets for metabolic disorders, cancer, and neurological diseases .

Role in the Life Cycle

Throughout the life cycle, FABPs play a critical role in development, aging, and disease . They are involved in the regulation of lipid metabolism and energy homeostasis, which are essential for growth and development . During aging, the levels of FABPs decline, which may contribute to age-associated decline in synaptic activity and other metabolic processes . In disease states, such as metabolic syndrome and cancer, FABPs are often dysregulated, highlighting their importance in maintaining cellular homeostasis .

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