Recombinant Proteins

p53
LBP
CEA
HLA
TCL
TTC
NPM
MAF
Bax
BID

CDC26 Human

Cell Division Cycle  26 Human Recombinant

Recombinant CDC26, of human origin, is produced in E. coli. This non-glycosylated polypeptide chain consists of 105 amino acids (specifically, amino acids 1 to 85) and has a molecular weight of 11.9 kDa. For purification and detection purposes, the CDC26 protein is engineered with a 20 amino acid His-tag fused to its N-terminus. Purification is carried out using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5828
Source
Escherichia Coli.
Appearance
A clear and sterile solution.

CDC34 Human

Cell Division Cycle 34 Human Recombinant

Recombinant human CDC34, produced in E. coli bacteria, is a single polypeptide chain without glycosylation. It consists of 236 amino acids, resulting in a molecular weight of 26.7 kDa. The purification of CDC34 is achieved through specialized chromatographic methods.

Shipped with Ice Packs
Cat. No.
BT5902
Source

Escherichia Coli. 

Appearance
A clear, sterile solution.

CDC34 Human, His

Cell Division Cycle 34 Human Recombinant, His Tag

Recombinant human CDC34 protein, expressed in E. coli, is a monomeric, non-glycosylated polypeptide chain. It consists of 256 amino acids, including a 20 amino acid N-terminal His-tag (total molecular weight: 28.9 kDa). The protein encompassing amino acids 1-236 of CDC34 is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5978
Source
Escherichia Coli.
Appearance
Clear, colorless solution, sterile-filtered.

CDC37 Human

Cell Division Cycle 37 Human Recombinant

Recombinantly produced in E. coli, CDC37 Human is a single, non-glycosylated polypeptide chain consisting of 378 amino acids. This protein has a molecular weight of 44.4 kDa.
Shipped with Ice Packs
Cat. No.
BT6084
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.

CDC37 Human, His

Cell Division Cycle 37 Human Recombinant, His Tag

CDC37, His Protein is a 45.71 kDa protein consisting of 388 amino acids. It also includes a 10 amino acid N-Terminal His-tag.
Shipped with Ice Packs
Cat. No.
BT6153
Source
E. coli

CDC123 Human

Cell Division Cycle 123 Human Recombinant

Recombinant human CDC123, expressed in E. coli, is a non-glycosylated polypeptide chain with 359 amino acids (including a 23 amino acid His-tag at the N-terminus) and a molecular weight of 41.5 kDa. It is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5692
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.

CDC25A Human

Cell Division Cycle 25A Human Recombinant

Recombinant human CDC25A, expressed in E. coli, is a single, non-glycosylated polypeptide chain with a molecular weight of 63.2 kDa. It consists of 560 amino acids (1-524 a.a.) and includes a 36 amino acid His tag at the N-terminus. Purification of CDC25A is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5762
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

CDC42 Human

Cell Division Cycle 42 Human Recombinant

CDC42 Human Recombinant, engineered with a 15 amino acid T7 tag at the N-terminus and produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 203 amino acids (1-188 a.a.) and exhibits a molecular weight of 22.4 kDa. This recombinant CDC42 protein undergoes purification using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT6261
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
Definition and Classification

The cell division cycle, also known as the cell cycle, is a series of events that cells go through to grow, replicate their DNA, and divide into two daughter cells. This process is essential for growth, development, and tissue repair in multicellular organisms, as well as for reproduction in unicellular organisms .

The cell cycle is classified into two main types based on the type of cell division:

  • Mitosis: This type of cell division results in two genetically identical daughter cells and is used for growth, tissue repair, and asexual reproduction in eukaryotic organisms .
  • Meiosis: This type of cell division results in four genetically diverse daughter cells with half the number of chromosomes of the parent cell. It is used for sexual reproduction in eukaryotic organisms .
Biological Properties

The cell cycle is characterized by several key biological properties:

  • Expression Patterns: The cell cycle is regulated by the expression of various cyclins and cyclin-dependent kinases (CDKs) that control the progression through different phases .
  • Tissue Distribution: The cell cycle occurs in all proliferating cells, including stem cells, somatic cells, and germ cells. However, the rate of cell division varies among different tissues. For example, cells in the bone marrow and gastrointestinal tract divide rapidly, while neurons and muscle cells divide infrequently .
Biological Functions

The primary biological functions of the cell cycle include:

  • Growth and Development: The cell cycle is essential for the growth and development of multicellular organisms, allowing them to increase in size and complexity .
  • Tissue Repair: The cell cycle enables the replacement of damaged or dead cells, maintaining tissue integrity and function .
  • Immune Responses and Pathogen Recognition: The cell cycle plays a role in the proliferation of immune cells, such as lymphocytes, which are crucial for mounting an effective immune response and recognizing pathogens .
Modes of Action

The cell cycle involves several mechanisms and interactions with other molecules and cells:

  • Binding Partners: Cyclins bind to CDKs, forming active complexes that phosphorylate target proteins to drive the cell cycle forward .
  • Downstream Signaling Cascades: The activation of cyclin-CDK complexes triggers downstream signaling cascades that regulate DNA replication, chromosome segregation, and cytokinesis .
Regulatory Mechanisms

The cell cycle is tightly regulated by various mechanisms to ensure accurate and timely cell division:

  • Transcriptional Regulation: The expression of cyclins and CDKs is regulated at the transcriptional level by transcription factors and other regulatory proteins .
  • Post-Translational Modifications: Cyclins and CDKs undergo post-translational modifications, such as phosphorylation and ubiquitination, which modulate their activity and stability .
  • Checkpoints: The cell cycle has several checkpoints, such as the G1/S checkpoint and the G2/M checkpoint, that monitor the integrity of the DNA and ensure that the cell is ready to proceed to the next phase .
Applications

The study of the cell cycle has numerous applications in biomedical research, diagnostics, and therapeutics:

  • Cancer Research: Understanding the cell cycle is crucial for cancer research, as dysregulation of the cell cycle is a hallmark of cancer. Targeting cell cycle regulators, such as CDKs, is a promising therapeutic strategy for cancer treatment .
  • Stem Cell Research: Insights into the cell cycle are essential for stem cell research, as the ability of stem cells to proliferate and differentiate is tightly linked to cell cycle regulation .
  • Diagnostic Tools: Cell cycle markers, such as Ki-67, are used as diagnostic tools to assess cell proliferation in various diseases, including cancer .
Role in the Life Cycle

The cell cycle plays a vital role throughout the life cycle of an organism:

  • Development: During embryonic development, rapid cell division is necessary for the formation of tissues and organs .
  • Aging: As organisms age, the regulation of the cell cycle becomes less efficient, leading to a decline in tissue regeneration and an increase in the risk of diseases, such as cancer .
  • Disease: Dysregulation of the cell cycle can lead to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases .
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