Recombinant Proteins

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Product List

CDC123 Human

Cell Division Cycle 123 Human Recombinant

CDC123 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 359 amino acids (1-336 a.a) and having a molecular mass of 41.5kDa.
CDC123 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5692
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

CDC25A Human

Cell Division Cycle 25A Human Recombinant

CDC25A Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 560 amino acids (1-524 a.a.) and having a molecular mass of 63.2kDa. The CDC25A is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5762
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.

CDC26 Human

Cell Division Cycle  26 Human Recombinant

CDC26 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 105 amino acids (1-85 a.a) and having a molecular mass of 11.9kDa.
CDC26 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5828
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.

CDC34 Human

Cell Division Cycle 34 Human Recombinant

Cell Division Cycle 34 Human Recombinant produced in E.Coli is a single, non- glycosylated polypeptide chain containing 236 amino acids and having a molecular mass of 26.7kDa.
CDC34 is purified by proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT5902
Source

Escherichia Coli. 

Appearance
Sterile Filtered colorless solution.

CDC34 Human, His

Cell Division Cycle 34 Human Recombinant, His Tag

CDC34 Human Recombinant protein fused to a 20 amino acid N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 256 amino acids (1-236 a.a.) and having a molecular mass of 28.9 kDa. CDC34 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT5978
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.

CDC37 Human

Cell Division Cycle 37 Human Recombinant

CDC37 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 378 amino acids and having a molecular mass of 44.4 kDa.
Shipped with Ice Packs
Cat. No.
BT6084
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.

CDC37 Human, His

Cell Division Cycle 37 Human Recombinant, His Tag

CDC37, His Protein is a 45.71 kDa protein containing 388 amino acids fused to a 10 aa
N-Terminal His-tag.
Shipped with Ice Packs
Cat. No.
BT6153
Source
E. coli
Appearance

CDC42 Human

Cell Division Cycle 42 Human Recombinant

CDC42 Human Recombinant fused with a 15 amino acid T7 tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 203 amino acids (1-188 a.a.) and having a molecular mass of 22.4kDa.
The CDC42 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT6261
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.

Introduction

Definition and Classification

The cell division cycle, also known as the cell cycle, is a series of events that cells go through to grow, replicate their DNA, and divide into two daughter cells. This process is essential for growth, development, and tissue repair in multicellular organisms, as well as for reproduction in unicellular organisms .

The cell cycle is classified into two main types based on the type of cell division:

  • Mitosis: This type of cell division results in two genetically identical daughter cells and is used for growth, tissue repair, and asexual reproduction in eukaryotic organisms .
  • Meiosis: This type of cell division results in four genetically diverse daughter cells with half the number of chromosomes of the parent cell. It is used for sexual reproduction in eukaryotic organisms .
Biological Properties

The cell cycle is characterized by several key biological properties:

  • Expression Patterns: The cell cycle is regulated by the expression of various cyclins and cyclin-dependent kinases (CDKs) that control the progression through different phases .
  • Tissue Distribution: The cell cycle occurs in all proliferating cells, including stem cells, somatic cells, and germ cells. However, the rate of cell division varies among different tissues. For example, cells in the bone marrow and gastrointestinal tract divide rapidly, while neurons and muscle cells divide infrequently .
Biological Functions

The primary biological functions of the cell cycle include:

  • Growth and Development: The cell cycle is essential for the growth and development of multicellular organisms, allowing them to increase in size and complexity .
  • Tissue Repair: The cell cycle enables the replacement of damaged or dead cells, maintaining tissue integrity and function .
  • Immune Responses and Pathogen Recognition: The cell cycle plays a role in the proliferation of immune cells, such as lymphocytes, which are crucial for mounting an effective immune response and recognizing pathogens .
Modes of Action

The cell cycle involves several mechanisms and interactions with other molecules and cells:

  • Binding Partners: Cyclins bind to CDKs, forming active complexes that phosphorylate target proteins to drive the cell cycle forward .
  • Downstream Signaling Cascades: The activation of cyclin-CDK complexes triggers downstream signaling cascades that regulate DNA replication, chromosome segregation, and cytokinesis .
Regulatory Mechanisms

The cell cycle is tightly regulated by various mechanisms to ensure accurate and timely cell division:

  • Transcriptional Regulation: The expression of cyclins and CDKs is regulated at the transcriptional level by transcription factors and other regulatory proteins .
  • Post-Translational Modifications: Cyclins and CDKs undergo post-translational modifications, such as phosphorylation and ubiquitination, which modulate their activity and stability .
  • Checkpoints: The cell cycle has several checkpoints, such as the G1/S checkpoint and the G2/M checkpoint, that monitor the integrity of the DNA and ensure that the cell is ready to proceed to the next phase .
Applications

The study of the cell cycle has numerous applications in biomedical research, diagnostics, and therapeutics:

  • Cancer Research: Understanding the cell cycle is crucial for cancer research, as dysregulation of the cell cycle is a hallmark of cancer. Targeting cell cycle regulators, such as CDKs, is a promising therapeutic strategy for cancer treatment .
  • Stem Cell Research: Insights into the cell cycle are essential for stem cell research, as the ability of stem cells to proliferate and differentiate is tightly linked to cell cycle regulation .
  • Diagnostic Tools: Cell cycle markers, such as Ki-67, are used as diagnostic tools to assess cell proliferation in various diseases, including cancer .
Role in the Life Cycle

The cell cycle plays a vital role throughout the life cycle of an organism:

  • Development: During embryonic development, rapid cell division is necessary for the formation of tissues and organs .
  • Aging: As organisms age, the regulation of the cell cycle becomes less efficient, leading to a decline in tissue regeneration and an increase in the risk of diseases, such as cancer .
  • Disease: Dysregulation of the cell cycle can lead to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases .
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