Recombinant Proteins
Product List
BID Mouse
BH3 Interacting Domain Death Agonist Mouse Recombinant
BID Mouse, GST
BH3 Interacting Domain Death Agonist Mouse Recombinant, GST
tBID Mouse
Truncated BH3 Interacting Domain Death Agonist Mouse Recombinant
BID Human
BH3 Interacting Domain Death Agonist Human Recombinant
Introduction
Key Biological Properties: BID is a pro-apoptotic protein containing only the BH3 domain. It is involved in the intrinsic pathway of apoptosis .
Expression Patterns: BID is expressed in various tissues, including lymphoid tissues, bone marrow, testis, and skeletal muscle .
Tissue Distribution: BID is found in multiple cell types, including lymphocytes, monocytes, neutrophils, and spermatocytes .
Primary Biological Functions: BID plays a crucial role in apoptosis by interacting with other Bcl-2 family proteins to induce mitochondrial outer membrane permeabilization and cytochrome c release .
Role in Immune Responses: BID is involved in the regulation of immune responses by mediating apoptosis in immune cells .
Pathogen Recognition: BID’s role in apoptosis helps in the elimination of infected cells, thereby contributing to pathogen recognition and clearance .
Mechanisms with Other Molecules and Cells: BID interacts with Bax, another Bcl-2 family protein, leading to the insertion of Bax into organelle membranes, primarily the outer mitochondrial membrane .
Binding Partners: BID binds to Bax and Bak, promoting their oligomerization and the formation of pores in the mitochondrial membrane .
Downstream Signaling Cascades: The activation of Bax and Bak by BID leads to the release of cytochrome c and other pro-apoptotic factors, triggering the caspase cascade and apoptosis .
Transcriptional Regulation: The expression of BID is upregulated by the tumor suppressor p53, which is activated in response to cellular stress .
Post-Translational Modifications: BID undergoes cleavage by caspase-8, resulting in the formation of truncated BID (tBID), which translocates to the mitochondria to induce apoptosis .
Biomedical Research: BID is studied extensively in the context of apoptosis and cancer research. Its role in cell death makes it a target for understanding cancer cell resistance to apoptosis .
Diagnostic Tools: BID expression levels can be used as a biomarker for certain cancers and diseases involving dysregulated apoptosis .
Therapeutic Strategies: Targeting BID and its interactions with other Bcl-2 family proteins is being explored as a therapeutic strategy for cancer treatment .
Development: BID is involved in the regulation of apoptosis during development, ensuring the proper elimination of cells .
Aging: Dysregulation of BID and apoptosis can contribute to age-related diseases and conditions .
Disease: BID plays a role in various diseases, including cancer, by regulating apoptosis and cell survival .
