Recombinant Proteins
Product List
CRK Human
V-crk Sarcoma Virus CT10 Oncogene Human Recombinant
CRKL Human
V-crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like Human Recombinant
Introduction
Key Biological Properties: V-crk Sarcoma Virus CT10 encodes a SH2 and SH3 domain-containing adaptor protein . These domains are crucial for its function in signal transduction.
Expression Patterns: The expression of CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is upregulated in multiple types of human cancers, including leukemia .
Tissue Distribution: CRKL is expressed in various tissues, with significant upregulation observed in cancerous tissues .
Primary Biological Functions: V-crk Sarcoma Virus CT10 plays a critical role in cell signaling by acting as an adaptor protein. It integrates signals from various sources, including growth factors, extracellular matrix molecules, and bacterial pathogens .
Role in Immune Responses: CRKL is involved in immune cell functions, particularly in the activation and inhibitory signaling of T, B, and natural killer (NK) cells .
Pathogen Recognition: CRKL’s role in immune responses suggests its involvement in pathogen recognition and subsequent immune activation .
Mechanisms with Other Molecules and Cells: V-crk Sarcoma Virus CT10 forms complexes with other proteins through its SH2 and SH3 domains. These complexes are essential for its role in signal transduction .
Binding Partners: CRKL interacts with various proteins, including BCR-ABL and TEL-ABL, leading to the activation of downstream signaling pathways .
Downstream Signaling Cascades: CRKL activates several signaling pathways, including the RAS and JUN kinase pathways, which are crucial for cell proliferation and survival .
Transcriptional Regulation: The expression of CRKL is regulated at the transcriptional level by factors such as ETV6, which can bind to the promoter region of CRKL .
Post-Translational Modifications: CRKL undergoes tyrosine phosphorylation, which is essential for its activation and function in signal transduction .
Biomedical Research: CRKL is a valuable target in cancer research due to its role in cell signaling and transformation .
Diagnostic Tools: The expression levels of CRKL can serve as biomarkers for certain cancers, aiding in diagnosis and prognosis .
Therapeutic Strategies: Targeting CRKL and its associated pathways offers potential therapeutic strategies for treating cancers and other diseases involving dysregulated signaling .
