Recombinant Proteins

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FAM49B Human

Family with Sequence Similarity 49, Member B Human Recombinant

Recombinant FAM49B Human, produced in E.Coli, is a single, non-glycosylated polypeptide chain. This protein consists of 347 amino acids (with a sequence of 1-324 a.a), resulting in a molecular mass of 39.1kDa. For purification purposes, FAM49B is tagged with a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8099
Source
E.coli.
Appearance
The product appears as a clear, colorless solution that has been sterilized through filtration.

FAM50A Human

Family with Sequence Similarity 50, Member A Human Recombinant

Recombinant FAM50A, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 213 amino acids (residues 150-339). With a molecular weight of 25.2 kDa, it features a 23 amino acid His-tag fused at the N-terminus. Purification is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT8187
Source
E.coli.
Appearance
The product is a sterile, colorless solution.

FAM107B Human

Family with Sequence Similarity 107, Member B Human Recombinant

FAM107B Human Recombinant protein is produced in E. coli. It is a single, non-glycosylated polypeptide chain containing 154 amino acids (residues 1-131) with a molecular weight of 17.9 kDa. A 23 amino acid His-tag is fused to the N-terminus. The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7730
Source
Escherichia Coli.
Appearance
A clear, colorless solution that is sterile filtered.

FAM3A Human

Family with Sequence Similarity 3, Member A Human Recombinant

Recombinant Human FAM3A, produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 207 amino acids, including a 10-amino acid N-terminal His-tag. The calculated molecular mass is 23.1 kDa.
Shipped with Ice Packs
Cat. No.
BT7802
Source
Escherichia Coli.
Appearance
White, lyophilized powder after filtration.

FAM3B Human

Family with Sequence Similarity 3, Member B Human Recombinant

FAM3B Protein consists of 216 amino acids, resulting in a molecular weight of 24.1 kDa. A 10 aa N-Terminal His-tag is also present.
Shipped with Ice Packs
Cat. No.
BT7871
Source
E. coli

FAM3C Human

Family with Sequence Similarity 3, Member C Human Recombinant

Recombinant human FAM3C, produced in E.coli, is a single, non-glycosylated polypeptide chain. It comprises 224 amino acids (residues 25-227) and has a molecular weight of 24.5 kDa. The protein is fused to a 21 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7931
Source
E.coli.
Appearance
A clear, colorless solution that is sterile filtered.

FAM3D Human

Family with Sequence Similarity 3, Member D Human Recombinant

FAM3D Human Recombinant, produced in E.Coli, is an un-glycosylated polypeptide chain with a single chain. It consists of amino acids 26-224 (a.a), totaling 209 amino acids. This includes a 10 a.a N-terminal His tag, resulting in a calculated total molecular mass of 23.3kDa.
Shipped with Ice Packs
Cat. No.
BT8018
Source
Escherichia Coli.
Appearance
White powder, lyophilized and filtered.

FAM84A Human

Family with Sequence Similarity 84, Member A Human Recombinant

Recombinant FAM84A, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 315 amino acids (residues 1-292) with a molecular weight of 34.9 kDa. This protein construct includes a 23 amino acid His-tag fused to the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8240
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

FAM84B Human

Family with Sequence Similarity 84, Member B Human Recombinant

Recombinant human FAM84B protein, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 333 amino acids (residues 1-310) with a molecular weight of 36.9 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT8298
Source
Escherichia Coli.
Appearance
A clear, colorless solution that is sterile and filtered.
Definition and Classification

The term “Family with Sequence Similarity” refers to groups of proteins or genes that share a significant degree of sequence similarity, indicating a common evolutionary origin. These families are classified based on their sequence homology, structural features, and functional properties. For instance, the Structural Classification of Proteins (SCOP) system classifies protein domains into families based on structural and functional evidence of a common evolutionary ancestor . Similarly, the Protein Information Resource (PIR) SuperFamily (PIRSF) classification system organizes proteins into families and subfamilies based on evolutionary relationships .

Biological Properties

Key Biological Properties: Members of a sequence similarity family often share conserved motifs and structural domains that are crucial for their function. These properties include specific amino acid sequences that form functional sites, such as active sites in enzymes or binding sites in receptors.

Expression Patterns and Tissue Distribution: The expression patterns of these families can vary widely. Some families are ubiquitously expressed across multiple tissues, while others are tissue-specific. For example, certain gene families involved in immune responses may be predominantly expressed in immune cells .

Biological Functions

Primary Biological Functions: The primary functions of these families can range from enzymatic activities to structural roles. For example, gene families involved in metabolic pathways often encode enzymes that catalyze specific biochemical reactions .

Role in Immune Responses and Pathogen Recognition: Some families play critical roles in the immune system. For instance, gene families encoding pattern recognition receptors (PRRs) are essential for detecting pathogen-associated molecular patterns (PAMPs) and initiating immune responses .

Modes of Action

Mechanisms with Other Molecules and Cells: Members of a sequence similarity family often interact with other molecules and cells through specific binding partners. These interactions can trigger downstream signaling cascades that regulate various cellular processes .

Binding Partners and Downstream Signaling Cascades: For example, receptors in the immune system may bind to ligands on pathogens, leading to the activation of signaling pathways that result in the production of cytokines and other immune mediators .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of these families are tightly regulated at multiple levels. Transcriptional regulation involves specific transcription factors that bind to promoter regions of genes, while post-translational modifications can alter protein activity, stability, and localization .

Transcriptional Regulation and Post-Translational Modifications: For instance, the MerR family of transcriptional regulators activates gene expression in response to environmental stimuli by binding to DNA and inducing conformational changes .

Applications

Biomedical Research: Sequence similarity families are invaluable in biomedical research for understanding disease mechanisms and identifying potential therapeutic targets. For example, studying gene families involved in cancer can reveal insights into tumorigenesis and metastasis .

Diagnostic Tools and Therapeutic Strategies: These families are also used in the development of diagnostic tools and therapeutic strategies. For instance, sequence similarity networks can help identify biomarkers for disease diagnosis and potential drug targets .

Role in the Life Cycle

Role Throughout the Life Cycle: The role of these families can vary throughout the life cycle, from development to aging and disease. During development, certain gene families are crucial for processes such as cell differentiation and organogenesis .

From Development to Aging and Disease: In aging and disease, changes in the expression and function of these families can contribute to age-related conditions and pathologies. For example, alterations in gene families involved in DNA repair can lead to genomic instability and cancer .

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