Recombinant Proteins

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RAB13 Human

RAB13, Member RAS Oncogene Family Human Recombinant

Recombinant human RAB13, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 220 amino acids (1-200) with a molecular weight of 24.7 kDa. It features a 20 amino acid His-Tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT6933
Source
Escherichia Coli.
Appearance
RAB13 is provided as a clear, sterile, and filtered solution.

RAB14 Human

RAB14, Member RAS Oncogene Family Human Recombinant

Recombinant human RAB14, produced in E.coli, is a single, non-glycosylated polypeptide chain comprising 238 amino acids (residues 1-215) with a molecular weight of 26.3 kDa. The RAB14 protein is fused to a 23-amino acid His-Tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7019
Source
Escherichia Coli.
Appearance
RAB14 is provided as a clear, sterile-filtered solution.

RAB17 Human

RAB17, Member RAS Oncogene Family Human Recombinant

This product consists of a recombinant human RAB17 protein produced in E. coli. It is a single, non-glycosylated polypeptide chain comprising 232 amino acids (residues 1-212) with a molecular weight of 25.6 kDa. The protein is designed with a 20 amino acid His-Tag fused at the N-terminus to facilitate purification, which is carried out using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7093
Source
Escherichia Coli.
Appearance
The RAB17 protein is provided as a clear solution that has undergone sterile filtration.

RAB18 Human

RAB18, Member RAS Oncogene Family Human Recombinant

Recombinant human RAB18, expressed in E. coli, is a non-glycosylated polypeptide chain consisting of 221 amino acids (residues 1-206) with a molecular weight of 24.5 kDa. This protein is engineered with a 15-amino acid His-tag at the N-terminus to facilitate purification using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT7202
Source
E.coli.
Appearance
Clear, colorless solution, sterile filtered.

RAB1A Human

RAB1A, Member RAS Oncogene Family Recombinant Human

This product consists of a single, non-glycosylated polypeptide chain of RAB1A, containing 225 amino acids (1-205.a.a) with a molecular weight of 24.8kDa. Produced in E. coli, it includes a 20 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7287
Source
Escherichia Coli.
Appearance
The product is a clear solution that has undergone sterile filtration.

RAB23 Human

RAB23, Member RAS Oncogene Family Human Recombinant

Recombinant human RAB23, expressed in E. coli, is a single, non-glycosylated polypeptide chain comprising 254 amino acids (residues 1-234) with a molecular weight of 28.5 kDa. This protein is fused to a 20 amino acid His-tag at the N-terminus and purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT7652
Source
E.coli.
Appearance
Clear, colorless solution that has undergone sterile filtration.

RAB27B Human

RAB27B, Member RAS Oncogene Family Human Recombinant

RAB27B Human Recombinant, with a 20 amino acid His tag at the N-terminus, is produced in E. coli. This single, non-glycosylated polypeptide chain comprises 238 amino acids (1-218 a.a.) and has a molecular weight of 26.7 kDa. The purification process for RAB27B involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8527
Source
Escherichia Coli.
Appearance
Sterile Filtered, colorless solution.

RAB2A Human

RAB2A, Member RAS Oncogene Family Human Recombinant

RAB2A, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 236 amino acids (specifically, amino acids 1 to 212). With a molecular mass of 26.1 kDa, it features a 24 amino acid His-tag fused at the N-terminus. The protein undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8596
Source
Escherichia Coli.
Appearance
A colorless solution that has been sterilized by filtration.

RAB2B Human

RAB2B, Member RAS Oncogene Family Human Recombinant

Recombinant human RAB2B, expressed in E. coli, is a non-glycosylated polypeptide chain with a molecular weight of 26.8 kDa. This protein consists of 240 amino acids, with residues 1-216 representing the RAB2B sequence. A 24-amino acid His-tag is fused to the N-terminus to facilitate purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8688
Source
E.coli.
Appearance
Clear, colorless solution, sterile-filtered.

RAB5C Human

RAB5C, Member RAS Oncogene Family Human Recombinant

RAB5C Human Recombinant, produced in E. coli, is a single polypeptide chain consisting of 239 amino acids (1-216) with a molecular weight of 25.9kDa. This protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT9896
Source
E.coli.
Appearance
Clear, colorless solution, sterilized by filtration.
Definition and Classification

The RAS oncogene family is a group of genes that encode small GTPases, which are involved in transmitting signals within cells. These proteins act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. The RAS family is divided into three main members: KRAS, HRAS, and NRAS . Each of these genes plays a crucial role in cell growth, differentiation, and survival.

Biological Properties

Key Biological Properties: RAS proteins are small GTPases that function as binary molecular switches. They are involved in various cellular processes, including cell proliferation, differentiation, and survival .

Expression Patterns: RAS proteins are ubiquitously expressed in all animal cell lineages and organs .

Tissue Distribution: These proteins are found in various tissues, including the brain, liver, pancreas, and skin .

Biological Functions

Primary Biological Functions: RAS proteins play a pivotal role in regulating cell proliferation, differentiation, and survival. They are involved in transmitting signals from cell surface receptors to the nucleus .

Role in Immune Responses and Pathogen Recognition: RAS proteins are involved in the immune response by regulating the activation and proliferation of immune cells. They also play a role in pathogen recognition by modulating signaling pathways that respond to infections .

Modes of Action

Mechanisms with Other Molecules and Cells: RAS proteins interact with various molecules and cells through their GTPase activity. They bind to guanine nucleotides (GTP and GDP) and cycle between active and inactive states .

Binding Partners: RAS proteins interact with a variety of binding partners, including guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which regulate their activity .

Downstream Signaling Cascades: Upon activation, RAS proteins initiate a cascade of downstream signaling events that lead to the activation of various effector proteins, including RAF kinases, PI3K, and RalGDS .

Regulatory Mechanisms

Transcriptional Regulation: The expression of RAS genes is regulated at the transcriptional level by various transcription factors and signaling pathways .

Post-Translational Modifications: RAS proteins undergo several post-translational modifications, including farnesylation, palmitoylation, and phosphorylation, which are essential for their proper localization and function .

Applications

Biomedical Research: RAS proteins are extensively studied in biomedical research due to their critical role in cancer development and progression .

Diagnostic Tools: Mutations in RAS genes are used as biomarkers for the diagnosis and prognosis of various cancers .

Therapeutic Strategies: Targeting RAS signaling pathways is a promising therapeutic strategy for treating RAS-driven cancers. Several inhibitors targeting RAS proteins and their downstream effectors are currently under development .

Role in the Life Cycle

Development: RAS proteins are essential for normal development, as they regulate cell proliferation and differentiation during embryogenesis .

Aging: The activity of RAS proteins is implicated in the aging process, as dysregulated RAS signaling can lead to cellular senescence and age-related diseases .

Disease: Mutations in RAS genes are associated with various diseases, including cancer, developmental disorders, and neurodegenerative diseases .

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