Recombinant Proteins
Product List
RHOA Human
Ras Homolog Gene Family Member A Human Recombinant
RHOB Human
Ras Homolog Gene Family Member B Human Recombinant
RHOC Human
Ras Homolog Gene Family Member C Human Recombinant
RAB1B Human
RAB1B, Member RAS Oncogene Family Human Recombinant
RAB21 Human
RAB21, Member RAS Oncogene Family Human Recombinant
RAB22A Human
RAB22, Member RAS Oncogene Family Recombinant Human
RHOQ Human
Ras Homolog Gene Family Member Q Human Recombinant
RHOV Human
Ras Homolog Gene Family Member V Human Recombinant
RAB31 Human
RAB31, Member RAS Oncogene Family Recombinant Human
RAB32 Human
RAB32, Member RAS Oncogene Family Human Recombinant
Introduction
The RAS oncogene family is a group of genes that encode small GTPases, which are involved in transmitting signals within cells. These proteins act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. The RAS family is divided into three main members: KRAS, HRAS, and NRAS . Each of these genes plays a crucial role in cell growth, differentiation, and survival.
Key Biological Properties: RAS proteins are small GTPases that function as binary molecular switches. They are involved in various cellular processes, including cell proliferation, differentiation, and survival .
Expression Patterns: RAS proteins are ubiquitously expressed in all animal cell lineages and organs .
Tissue Distribution: These proteins are found in various tissues, including the brain, liver, pancreas, and skin .
Primary Biological Functions: RAS proteins play a pivotal role in regulating cell proliferation, differentiation, and survival. They are involved in transmitting signals from cell surface receptors to the nucleus .
Role in Immune Responses and Pathogen Recognition: RAS proteins are involved in the immune response by regulating the activation and proliferation of immune cells. They also play a role in pathogen recognition by modulating signaling pathways that respond to infections .
Mechanisms with Other Molecules and Cells: RAS proteins interact with various molecules and cells through their GTPase activity. They bind to guanine nucleotides (GTP and GDP) and cycle between active and inactive states .
Binding Partners: RAS proteins interact with a variety of binding partners, including guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which regulate their activity .
Downstream Signaling Cascades: Upon activation, RAS proteins initiate a cascade of downstream signaling events that lead to the activation of various effector proteins, including RAF kinases, PI3K, and RalGDS .
Transcriptional Regulation: The expression of RAS genes is regulated at the transcriptional level by various transcription factors and signaling pathways .
Post-Translational Modifications: RAS proteins undergo several post-translational modifications, including farnesylation, palmitoylation, and phosphorylation, which are essential for their proper localization and function .
Biomedical Research: RAS proteins are extensively studied in biomedical research due to their critical role in cancer development and progression .
Diagnostic Tools: Mutations in RAS genes are used as biomarkers for the diagnosis and prognosis of various cancers .
Therapeutic Strategies: Targeting RAS signaling pathways is a promising therapeutic strategy for treating RAS-driven cancers. Several inhibitors targeting RAS proteins and their downstream effectors are currently under development .
Development: RAS proteins are essential for normal development, as they regulate cell proliferation and differentiation during embryogenesis .
Aging: The activity of RAS proteins is implicated in the aging process, as dysregulated RAS signaling can lead to cellular senescence and age-related diseases .
Disease: Mutations in RAS genes are associated with various diseases, including cancer, developmental disorders, and neurodegenerative diseases .
