Recombinant Proteins

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SURF1 Human

Surfeit-1 Human Recombinant

This product consists of the recombinant human Surfeit-1 protein, produced in E. coli bacteria. It is a single, non-glycosylated polypeptide chain comprising 215 amino acids (specifically, residues 80-273). With a molecular weight of 24.3 kDa, the Surfeit-1 protein is fused to a 20 amino acid Histidine Tag at its N-terminus. Purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5278
Source
Escherichia Coli.
Appearance
The product is a sterile, filtered solution that appears colorless.

SURF2 Human

Surfeit-2 Human Recombinant

Recombinantly produced in E. coli, SURF2 Human Recombinant is a single, non-glycosylated polypeptide chain. This protein comprises 279 amino acids (1-256) with a molecular weight of 32 kDa. For purification, a 23 amino acid His-tag is fused to the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT5294
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile-filtered solution.
Definition and Classification

The term “surfeit” generally refers to an excessive amount of something. In biological contexts, the Surfeit locus is a cluster of six tightly packed genes (Surf1 to Surf6) that are involved in various cellular processes .

Biological Properties

Key Biological Properties: The Surfeit genes encode proteins with diverse functions. For instance, SURF6 is a nucleolar protein involved in ribosome biogenesis .

Expression Patterns: These genes are ubiquitously expressed in various tissues, indicating their fundamental roles in cellular functions .

Tissue Distribution: Surfeit proteins are found in multiple tissues, including the liver, brain, and heart, reflecting their involvement in essential physiological processes .

Biological Functions

Primary Biological Functions: Surfeit proteins play crucial roles in ribosome biogenesis, protein trafficking, and lipid metabolism .

Role in Immune Responses and Pathogen Recognition: Some Surfeit proteins, like SURF4, are involved in the secretion of immune-related molecules, thereby contributing to immune responses .

Modes of Action

Mechanisms with Other Molecules and Cells: Surfeit proteins interact with various cellular components. For example, SURF4 functions as a cargo receptor, mediating the transport of proteins between the endoplasmic reticulum and the Golgi apparatus .

Binding Partners and Downstream Signaling Cascades: SURF6 binds to both DNA and RNA, suggesting its role in nucleic acid metabolism . These interactions often trigger downstream signaling pathways that regulate cell growth and differentiation .

Regulatory Mechanisms

Transcriptional Regulation: The expression of Surfeit genes is tightly regulated at the transcriptional level to ensure proper cellular function .

Post-Translational Modifications: Surfeit proteins undergo various post-translational modifications, such as phosphorylation, which modulate their activity and stability .

Applications

Biomedical Research: Surfeit proteins are studied for their roles in diseases like cancer and neurodegenerative disorders .

Diagnostic Tools: The expression levels of Surfeit genes can serve as biomarkers for certain diseases .

Therapeutic Strategies: Targeting Surfeit proteins offers potential therapeutic avenues for treating metabolic and infectious diseases .

Role in the Life Cycle

Development to Aging and Disease: Surfeit proteins are involved in critical stages of the life cycle, from embryonic development to aging. Their dysregulation is associated with various diseases, including cancer and metabolic disorders .

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