Recombinant Proteins

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MAPRE3 Human

Microtubule-Associated Protein, RP/EB Family, Member 3 Human Recombinant

This recombinant MAPRE3 protein, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 301 amino acids (residues 1-281) with a molecular weight of 34.1 kDa. It includes an N-terminal 20 amino acid His-tag for purification purposes, which is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT12891
Source
Escherichia Coli.
Appearance
Clear, sterile filtered solution.

MAPT Human

Microtubule-Associated Protein Tau Human Recombinant

This product consists of a recombinant human MAPT protein, specifically isoform 4. It is produced in E. coli and comprises 372 amino acids, including a 20-amino acid histidine tag at the N-terminus. The protein has a molecular weight of 38.9 kDa. Notably, the observed molecular weight on SDS-PAGE might be slightly higher. The purification process involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT12979
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

MAPT Human 381a.a.

Microtubule-Associated Protein Tau 381 a.a. Human Recombinant

This product is a recombinant human MAPT protein consisting of 401 amino acids (including a 20 amino acid His tag at the N-terminus). It is produced in E. coli and has a molecular weight of 41.8 kDa. This protein is not glycosylated and corresponds to amino acids 1-381 of the human MAPT protein (NCBI Accession No. EAW93573.1). The protein is purified using proprietary chromatographic methods to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT13050
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile filtered solution.

MAPT Human 383a.a.

Microtubule-Associated Protein Tau 383 a.a. Human Recombinant

MAPT Human Recombinant (Isoform 3) is a single, non-glycosylated polypeptide chain containing 403 amino acids (1-383 a.a.) with a 20 amino acid His tag at the N-terminus. It is produced in E. coli and has a molecular mass of 42.1 kDa (Molecular size on SDS-PAGE will appear higher). The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT13126
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution

MAP1LC3A Human

Microtubule-Associated Protein 1 Light Chain 3 Alpha Human Recombinant

Recombinant Human MAP1LC3A, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 128 amino acids (including an 8-amino acid His-Tag at the C-terminus). It has a molecular weight of 15.1 kDa. Purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT12437
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

MAP1LC3B Human

Microtubule-Associated Protein 1 Light Chain 3 Beta Human Recombinant

Produced in E. coli, MAP1LC3B is a single, non-glycosylated polypeptide chain consisting of 140 amino acids (1-120a.a.) with a molecular weight of 16.2kDa. It is fused to a 20 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT12514
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.

MAP1LC3B2 Human

Microtubule-Associated Protein 1 Light Chain 3 Beta 2 Human Recombinant

Produced in E. coli, MAP1LC3B2 is a single, non-glycosylated polypeptide chain consisting of 140 amino acids (specifically, amino acids 1-120). With a molecular weight of 16.2 kDa, this protein is fused to a 20 amino acid His-tag at the N-terminus and undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT12637
Source
Escherichia Coli.
Appearance
The product is provided as a sterile, colorless solution.

MAPRE1 Human

Microtubule-Associated Protein, RP/EB Family, Member 1 Human Recombinant

Recombinant human MAPRE1, with a 20 amino acid His tag attached at its N-terminus, is produced in E. coli. This results in a single, non-glycosylated polypeptide chain of 288 amino acids (specifically, amino acids 1 to 268). The molecular weight of the recombinant protein is 32.2 kDa. Purification of MAPRE1 is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT12742
Source
Escherichia Coli.
Appearance
A clear, sterile solution.

MAPRE2 Human

Microtubule-Associated Protein, RP/EB Family, Member 2 Human Recombinant

This product contains a purified version of the human MAPRE2 protein. It is produced in bacteria (E. coli) and has a molecular weight of 39.2 kDa. The protein sequence contains amino acids 1-327 of the human MAPRE2 protein, with an additional 20 amino acid tag to aid in purification.
Shipped with Ice Packs
Cat. No.
BT12817
Source
Escherichia Coli.
Appearance
Clear liquid solution.

MAPT Human 412a.a.

Microtubule-Associated Protein Tau 412 a.a. Human Recombinant

This product consists of the human MAPT protein, specifically isoform 5, produced in E. coli bacteria. It is a single, non-glycosylated polypeptide chain of 432 amino acids, with a His tag attached to the N-terminus for purification purposes. The molecular weight of the protein is 45.1 kDa, but it may appear larger on SDS-PAGE. The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT13219
Source
Escherichia Coli.
Appearance
Clear and colorless solution that has been sterilized by filtration.
Definition and Classification

Microtubule-Associated Proteins (MAPs) are proteins that interact with microtubules, which are part of the cellular cytoskeleton. They play a crucial role in stabilizing microtubules and facilitating the transport of cellular components . MAPs are classified into several categories based on their structure and function:

  • Structural MAPs: These bind along the microtubules and include MAP1, MAP2, MAP4, and Tau families .
  • +TIP MAPs: These bind to the growing ends of microtubules and include motor proteins like kinesin and dynein .
Biological Properties

MAPs exhibit diverse biological properties:

  • Key Biological Properties: MAPs stabilize microtubules by binding to tubulin dimers, which can occur with either polymerized or depolymerized tubulin .
  • Expression Patterns: Different MAPs are expressed in various cell types. For example, MAP1 is found in the axons and dendrites of nerve cells .
  • Tissue Distribution: MAPs are distributed across different tissues, with specific MAPs like MAP2 being involved in neuronal development and present in mature dendrites .
Biological Functions

MAPs have several primary biological functions:

  • Microtubule Stabilization: They stabilize microtubules, which is essential for maintaining cell structure and facilitating intracellular transport .
  • Role in Immune Responses and Pathogen Recognition: MAPs are involved in immune responses by regulating the stability and dynamics of microtubules, which are crucial for cell division and motility .
Modes of Action

MAPs interact with other molecules and cells through various mechanisms:

  • Binding Partners: MAPs bind to tubulin dimers and other cellular components like vesicles and intermediate filaments .
  • Downstream Signaling Cascades: MAPs influence downstream signaling pathways by stabilizing microtubules and facilitating the transport of signaling molecules .
Regulatory Mechanisms

The expression and activity of MAPs are tightly regulated:

  • Transcriptional Regulation: The expression of MAPs is controlled at the transcriptional level by various transcription factors .
  • Post-Translational Modifications: MAPs undergo post-translational modifications such as phosphorylation, which regulates their binding to microtubules .
Applications

MAPs have several applications in biomedical research and therapeutic strategies:

  • Biomedical Research: MAPs are studied to understand their role in neurodegenerative diseases like Alzheimer’s disease .
  • Diagnostic Tools: MAPs, particularly Tau protein, are used as biomarkers for diagnosing neurodegenerative diseases .
  • Therapeutic Strategies: Targeting MAPs is being explored as a potential therapeutic approach for treating diseases like cancer and neurodegenerative disorders .
Role in the Life Cycle

MAPs play a role throughout the life cycle, from development to aging and disease:

  • Development: MAPs like MAP2 are involved in neuronal development and axon formation .
  • Aging and Disease: Abnormal modifications of MAPs, such as hyperphosphorylation of Tau protein, are associated with neurodegenerative diseases like Alzheimer’s disease .
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