Recombinant Proteins

p53
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CEA
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Bet v 1.0101

Major pollen allergen Bet v 1-A Recombinant

Recombinant Major pollen allergen Bet v 1-A, produced in SF9 insect cells, is a single, glycosylated polypeptide chain. It comprises 167 amino acids (specifically, residues 2 to 160) and exhibits a molecular mass of 18.5 kDa as determined through calculations. This variant, Bet v 1.0101, includes an 8 amino acid fusion tag located at the N-terminus.
Shipped with Ice Packs
Cat. No.
BT16172
Source

Escherichia Coli.

Appearance
The product appears as a clear solution that has undergone sterile filtration.

Bet v 1.0101, Sf9

Major pollen allergen Bet v 1-A Recombinant, Sf9

Recombinant Major pollen allergen Bet v 1-A, produced in Sf9 insect cells, is a glycosylated polypeptide chain with a molecular weight of 18,942 Daltons. It features a 10xHis tag at the N-terminus for purification purposes and is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT16236
Source
Sf9 insect cells.
Appearance
The product is a clear solution that has undergone sterile filtration.

Bet v 2.0101

Profilin-1 Recombinant

Recombinant Profilin-1 (Bet v 2.0101) is produced using E. coli bacteria and is a non-glycosylated polypeptide chain with a molecular weight of 15,625 Daltons. This recombinant protein is modified to include a 10xHis tag at its N-terminus to facilitate purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16318
Source
Escherichia Coli.
Appearance
Clear solution that has been sterilized by filtration.

BETV4

Polcalcin Bet v 4 Recombinant

Recombinant BETV4, produced in SF9 insect cells, is a glycosylated polypeptide chain with a calculated molecular mass of 10,473 Daltons. It is expressed with an N-terminal 6xHis tag and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16403
Source
Sf9 insect cells.
Appearance
Clear, sterile-filtered solution.

BETV6.0102

Allergenic Isoflavone Reductase-Like Protein Bet v 6.0102 Recombinant

Produced in SF9 cells, recombinant BETV6.0102 is a glycosylated polypeptide chain with a calculated molecular mass of 36,636 Daltons. It features a 10xHis tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16487
Source
Sf9 insect cells.
Appearance
Clear, sterile-filtered solution.

Ara h 1.0101

Allergen Ara h 1.0101 Recombinant

Recombinant Allergen Ara h 1.0101, expressed in SF9 insect cells, is a glycosylated polypeptide chain with a calculated molecular mass of 63,484 Daltons. This recombinant protein is engineered with a 9xHis tag at the N-terminus to facilitate purification, which is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15716
Source
Sf9 insect cells.
Appearance
Clear solution, sterile-filtered.

Ara h 2.0201

Allergen Ara h 2.0201 (Conglutin-7) Recombinant

Recombinant Allergen Ara h 2.0201, expressed in SF9 cells, is a glycosylated polypeptide chain with a molecular weight of 20 kDa. It is engineered with an N-terminal 10xHis tag and purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT15807
Source
Sf9 insect cells.
Appearance
Clear, sterile-filtered solution.

Ara h 8.0101

Allergen Ara h 8.0101 Recombinant

Recombinant Ara h 8.0101, expressed in SF9 cells, is a glycosylated polypeptide chain with a calculated molecular mass of 18,192 Daltons. It is produced with a 10xHis tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15901
Source
Sf9 insect cells.
Appearance
A clear, sterile-filtered solution.

Ara h 9.0101

Allergen Ara h 9.0101 Recombinant

Recombinant Ara h 9.0101, synthesized in SF9 insect cells, is a glycosylated polypeptide with a molecular weight of 9,959 Daltons. The protein is engineered with a 6xHis tag at its N-terminus to facilitate purification, which is carried out using proprietary chromatographic methods.

Shipped with Ice Packs
Cat. No.
BT16003
Source
Sf9 insect cells.
Appearance
A clear solution that has been sterilized by filtration.

Art v 1

Major Pollen Allergen Art v 1 Recombinant

Recombinant Art v 1, produced in SF9 insect cells, is a glycosylated polypeptide chain with a molecular weight of 11,486 Daltons. It is expressed with a 5xHis tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16085
Source
Sf9 insect cells.
Appearance
Clear, sterile, and filtered solution.
Definition and Classification

Allergy is an immune system response to a foreign substance (allergen) that is not typically harmful to the body. These foreign substances can include pollen, pet dander, certain foods, and insect stings. Allergies are classified into several types based on the mechanism of the immune response:

  • Type I (Immediate Hypersensitivity): Mediated by IgE antibodies, leading to reactions such as hay fever, asthma, and anaphylaxis.
  • Type II (Cytotoxic Hypersensitivity): Involves IgG or IgM antibodies targeting cells, leading to conditions like hemolytic anemia.
  • Type III (Immune Complex Hypersensitivity): Involves immune complexes that deposit in tissues, causing conditions like systemic lupus erythematosus.
  • Type IV (Delayed-Type Hypersensitivity): Mediated by T cells, leading to reactions such as contact dermatitis and tuberculin reactions.
Biological Properties
  • Key Biological Properties: Allergies involve the immune system’s overreaction to harmless substances. Key players include IgE antibodies, mast cells, basophils, and various cytokines.
  • Expression Patterns: IgE antibodies are produced by B cells and are specific to particular allergens. Mast cells and basophils express high-affinity IgE receptors (FcεRI).
  • Tissue Distribution: Mast cells are found in connective tissues, particularly near blood vessels and nerves, while basophils circulate in the blood.
Biological Functions
  • Primary Biological Functions: The primary function of the allergic response is to protect the body from perceived threats. This involves the release of histamines and other mediators that cause inflammation and other symptoms.
  • Role in Immune Responses: Allergies play a role in immune responses by activating various immune cells and mediators.
  • Pathogen Recognition: Although allergies are typically responses to non-pathogenic substances, the mechanisms involved are similar to those used in pathogen recognition.
Modes of Action
  • Mechanisms with Other Molecules and Cells: Allergens bind to IgE antibodies on the surface of mast cells and basophils, leading to cell activation and degranulation.
  • Binding Partners: Key binding partners include IgE antibodies, FcεRI receptors, and allergens.
  • Downstream Signaling Cascades: Activation of mast cells and basophils leads to the release of histamines, leukotrienes, and other inflammatory mediators, triggering symptoms like itching, swelling, and bronchoconstriction.
Regulatory Mechanisms
  • Regulatory Mechanisms: The expression and activity of IgE and other molecules involved in allergic responses are tightly regulated by various factors.
  • Transcriptional Regulation: Genes encoding IgE and FcεRI are regulated by transcription factors such as NF-κB.
  • Post-Translational Modifications: Post-translational modifications, such as phosphorylation, play a role in the activation and function of immune cells involved in allergies.
Applications
  • Biomedical Research: Understanding allergies helps in developing treatments and preventive measures.
  • Diagnostic Tools: Skin prick tests, blood tests for specific IgE, and challenge tests are used to diagnose allergies.
  • Therapeutic Strategies: Treatments include antihistamines, corticosteroids, and immunotherapy (allergy shots).
Role in the Life Cycle
  • Throughout the Life Cycle: Allergies can develop at any age and may change over time. They can affect quality of life and may be associated with other conditions such as asthma and eczema.
  • From Development to Aging and Disease: Allergies can impact various stages of life, from childhood to old age, and may influence the development of other immune-related diseases.
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