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Recombinant Proteins
Product List
Pen a 1.0101
Tropomyosin Pen a 1.0101 Recombinant
Recombinant Tropomyosin Pen a 1.0101, expressed in SF9 cells, is a glycosylated polypeptide chain with a calculated molecular mass of 38kDa. This protein is expressed with a 10xHis tag and purified using proprietary chromatographic techniques.
Shipped with Ice Packs 
Cat. No.
BT17759
Source
Sf9 insect cells.
Appearance
A sterile, colorless, and filtered solution.
PhI p 1
Pollen allergen Phl p 1 Recombinant
Crafted using SF9 cells, the recombinant Phl p 1 allergen is a glycosylated polypeptide boasting a molecular weight of 29,516 Daltons. Its production incorporates a 10xHis tag at the N-terminus, followed by purification using advanced chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT17838
Source
Sf9 insect cells.
Appearance
The product is presented as a clear solution that has undergone sterile filtration.
Aln G 1.0101
Major pollen allergen Aln g 1 Recombinant
Recombinant Major pollen allergen Aln g 1, synthesized in SF9 cells, is a glycosylated polypeptide chain with a calculated molecular mass of 18,710 Daltons. It features a 10xHis tag positioned at the N-terminus and undergoes purification using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT15569
Source
Sf9 insect cells.
Appearance
A clear solution that has undergone sterile filtration.
Aln G 4.0101
Polcalcin Aln g 4 Recombinant
Recombinant Polcalcin Aln g 4, a glycosylated polypeptide chain with a calculated molecular mass of 10,185 Daltons, is produced in SF9 cells. This protein (Aln G 4.0101) is engineered with a 6xHis tag at the N-terminus and purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT15646
Source
Sf9 insect cells.
Appearance
A clear, sterile-filtered solution.
Car b 1.0109
Pollen allergen Car b 1 isoform Recombinant
Recombinant Pollen allergen Car b 1 isoform, expressed in E. coli, is a non-glycosylated polypeptide chain with a calculated molecular mass of 18kDa. Car b 1.0109 is expressed with an N-terminal 10xHis tag and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Conglutin
Allergen Ara h 6.0101 Recombinant
Recombinant Conglutin, expressed in SF9 insect cells, is a glycosylated polypeptide chain with a calculated molecular mass of 16,217 Daltons.
The recombinant Conglutin is engineered with a 10xHis tag at the N-terminus to facilitate purification, which is carried out using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT16638
Source
Sf9 insect cells.
Appearance
A clear solution that has undergone sterile filtration.
Cor a 1.0103
Major pollen allergen Cor a 1 Recombinant
Recombinant Major pollen allergen Cor a 1.0103, expressed in SF9 insect cells, is a glycosylated polypeptide with a predicted molecular weight of 17.47 kDa. Purification is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT16724
Source
Sf9 insect cells.
Appearance
A clear solution that has undergone sterile filtration.
Cor a 1.0401
Major Pollen Allergen Cor a 1 .0401 Recombinant
Recombinant Cor a 1.0401, produced in SF9 insect cells, is a glycosylated polypeptide chain with a calculated molecular mass of 18,952 Daltons. It is expressed with a 10xHis tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Introduction
Definition and Classification
Allergy is an immune system response to a foreign substance (allergen) that is not typically harmful to the body. These foreign substances can include pollen, pet dander, certain foods, and insect stings. Allergies are classified into several types based on the mechanism of the immune response:
- Type I (Immediate Hypersensitivity): Mediated by IgE antibodies, leading to reactions such as hay fever, asthma, and anaphylaxis.
- Type II (Cytotoxic Hypersensitivity): Involves IgG or IgM antibodies targeting cells, leading to conditions like hemolytic anemia.
- Type III (Immune Complex Hypersensitivity): Involves immune complexes that deposit in tissues, causing conditions like systemic lupus erythematosus.
- Type IV (Delayed-Type Hypersensitivity): Mediated by T cells, leading to reactions such as contact dermatitis and tuberculin reactions.
Biological Properties
- Key Biological Properties: Allergies involve the immune system’s overreaction to harmless substances. Key players include IgE antibodies, mast cells, basophils, and various cytokines.
- Expression Patterns: IgE antibodies are produced by B cells and are specific to particular allergens. Mast cells and basophils express high-affinity IgE receptors (FcεRI).
- Tissue Distribution: Mast cells are found in connective tissues, particularly near blood vessels and nerves, while basophils circulate in the blood.
Biological Functions
- Primary Biological Functions: The primary function of the allergic response is to protect the body from perceived threats. This involves the release of histamines and other mediators that cause inflammation and other symptoms.
- Role in Immune Responses: Allergies play a role in immune responses by activating various immune cells and mediators.
- Pathogen Recognition: Although allergies are typically responses to non-pathogenic substances, the mechanisms involved are similar to those used in pathogen recognition.
Modes of Action
- Mechanisms with Other Molecules and Cells: Allergens bind to IgE antibodies on the surface of mast cells and basophils, leading to cell activation and degranulation.
- Binding Partners: Key binding partners include IgE antibodies, FcεRI receptors, and allergens.
- Downstream Signaling Cascades: Activation of mast cells and basophils leads to the release of histamines, leukotrienes, and other inflammatory mediators, triggering symptoms like itching, swelling, and bronchoconstriction.
Regulatory Mechanisms
- Regulatory Mechanisms: The expression and activity of IgE and other molecules involved in allergic responses are tightly regulated by various factors.
- Transcriptional Regulation: Genes encoding IgE and FcεRI are regulated by transcription factors such as NF-κB.
- Post-Translational Modifications: Post-translational modifications, such as phosphorylation, play a role in the activation and function of immune cells involved in allergies.
Applications
- Biomedical Research: Understanding allergies helps in developing treatments and preventive measures.
- Diagnostic Tools: Skin prick tests, blood tests for specific IgE, and challenge tests are used to diagnose allergies.
- Therapeutic Strategies: Treatments include antihistamines, corticosteroids, and immunotherapy (allergy shots).
Role in the Life Cycle
- Throughout the Life Cycle: Allergies can develop at any age and may change over time. They can affect quality of life and may be associated with other conditions such as asthma and eczema.
- From Development to Aging and Disease: Allergies can impact various stages of life, from childhood to old age, and may influence the development of other immune-related diseases.
