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Recombinant Proteins
Product List
Tri a 14.0101
Non-Specific Lipid-Transfer Protein Tri a 14 Recombinant
Recombinant Non-Specific Lipid-Transfer Protein Tri a 14, produced in SF9 insect cells, is a glycosylated polypeptide chain with a calculated molecular mass of 13kDa. This protein is expressed with a 6xHis tag for purification and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs 
Cor a 14.0101
2S albumin Recombinant
Recombinant 2S albumin, produced in SF9 cells, is a glycosylated polypeptide chain with a molecular mass of 14kDa. Cor a 14.0101 is expressed with a 6xHis tag and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16927
Source
Sf9 insect cells.
Appearance
Sterile Filtered colorless solution.
Cor a 8.0101
Non-specific Lipid-Transfer Protein Cor a 8 Recombinant
Recombinant Non-specific Lipid-Transfer Protein Cor a 8 produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 11kDa. Cor a 8.0101 is expressed with a 10xHis tag and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT17040
Source
Sf9 insect cells.
Appearance
Sterile Filtered colorless solution.
Cor a 9
Corylus Avellana Cor a 9
The protein, Corylus Avellana Cor a 9, is extracted from hazelnuts and purified using specialized protein chemical methods.
Shipped with Ice Packs
Cat. No.
BT17109
Appearance
The product is a clear solution that has been sterilized through filtration.
Der F1
Der F1 Mosaic Protein Recombinant
This recombinant protein, expressed in E. coli, encompasses the full-length Dermatophagoides farina Der F1 protein (amino acids 1-320) with a C-terminal 6-His tag. It possesses a molecular weight of 36 kDa and an isoelectric point of 5.88.
Shipped with Ice Packs
Cat. No.
BT17187
Source
E.Coli.
Appearance
The product is a sterile-filtered, colorless solution.
Gly m 4.0101
Stress-Induced Protein SAM22 Recombinant
Recombinant Stress-Induced Protein SAM22, expressed in SF9 cells, is a glycosylated polypeptide chain with a molecular weight of 19,484 Daltons. The protein is tagged with a 10xHis tag at the N-terminus and purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT17401
Source
Sf9 insect cells.
Appearance
A clear, sterile-filtered solution.
Gly m 5.0101
Alpha Subunit of Beta Conglycinin Recombinant
Recombinantly produced in SF9 cells, the Alpha Subunit of Beta Conglycinin (Gly m 5.0101) is a glycosylated polypeptide with a predicted molecular weight of 70,586 Daltons. This protein is engineered with a 10xHis tag located at the N-terminus to facilitate purification, which is achieved through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT17482
Source
Sf9 insect cells.
Appearance
The product is a clear solution that has been sterilized by filtration.
Glycinin
Allergen Ara h 3.0101 Recombinant
Recombinant Glycinin, produced in E. coli, is a non-glycosylated polypeptide chain with a calculated molecular mass of 63 kDa. It is expressed with a 10xHis tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
MALD1
Major Allergen Mal d 1 Recombinant (Mal d 1.0108)
When produced in SF9 cells, recombinant MALD1 is a glycosylated polypeptide chain with a calculated molecular mass of 17,492 Daltons.
The purification of MALD1 is achieved through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT17628
Source
Sf9 insect cells.
Appearance
A clear solution that has undergone sterile filtration.
MALD3
Non-Specific Lipid-Transfer Protein Mal d 3 Recombinant
Recombinant Non-Specific Lipid-Transfer Protein Mal d 3, produced in SF9 cells, is a glycosylated polypeptide chain with a calculated molecular mass of 12kDa. It is expressed with a 6xHis tag and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT17699
Source
Sf9 insect cells.
Appearance
Clear, colorless solution, sterile-filtered.
Introduction
Definition and Classification
Allergy is an immune system response to a foreign substance (allergen) that is not typically harmful to the body. These foreign substances can include pollen, pet dander, certain foods, and insect stings. Allergies are classified into several types based on the mechanism of the immune response:
- Type I (Immediate Hypersensitivity): Mediated by IgE antibodies, leading to reactions such as hay fever, asthma, and anaphylaxis.
- Type II (Cytotoxic Hypersensitivity): Involves IgG or IgM antibodies targeting cells, leading to conditions like hemolytic anemia.
- Type III (Immune Complex Hypersensitivity): Involves immune complexes that deposit in tissues, causing conditions like systemic lupus erythematosus.
- Type IV (Delayed-Type Hypersensitivity): Mediated by T cells, leading to reactions such as contact dermatitis and tuberculin reactions.
Biological Properties
- Key Biological Properties: Allergies involve the immune system’s overreaction to harmless substances. Key players include IgE antibodies, mast cells, basophils, and various cytokines.
- Expression Patterns: IgE antibodies are produced by B cells and are specific to particular allergens. Mast cells and basophils express high-affinity IgE receptors (FcεRI).
- Tissue Distribution: Mast cells are found in connective tissues, particularly near blood vessels and nerves, while basophils circulate in the blood.
Biological Functions
- Primary Biological Functions: The primary function of the allergic response is to protect the body from perceived threats. This involves the release of histamines and other mediators that cause inflammation and other symptoms.
- Role in Immune Responses: Allergies play a role in immune responses by activating various immune cells and mediators.
- Pathogen Recognition: Although allergies are typically responses to non-pathogenic substances, the mechanisms involved are similar to those used in pathogen recognition.
Modes of Action
- Mechanisms with Other Molecules and Cells: Allergens bind to IgE antibodies on the surface of mast cells and basophils, leading to cell activation and degranulation.
- Binding Partners: Key binding partners include IgE antibodies, FcεRI receptors, and allergens.
- Downstream Signaling Cascades: Activation of mast cells and basophils leads to the release of histamines, leukotrienes, and other inflammatory mediators, triggering symptoms like itching, swelling, and bronchoconstriction.
Regulatory Mechanisms
- Regulatory Mechanisms: The expression and activity of IgE and other molecules involved in allergic responses are tightly regulated by various factors.
- Transcriptional Regulation: Genes encoding IgE and FcεRI are regulated by transcription factors such as NF-κB.
- Post-Translational Modifications: Post-translational modifications, such as phosphorylation, play a role in the activation and function of immune cells involved in allergies.
Applications
- Biomedical Research: Understanding allergies helps in developing treatments and preventive measures.
- Diagnostic Tools: Skin prick tests, blood tests for specific IgE, and challenge tests are used to diagnose allergies.
- Therapeutic Strategies: Treatments include antihistamines, corticosteroids, and immunotherapy (allergy shots).
Role in the Life Cycle
- Throughout the Life Cycle: Allergies can develop at any age and may change over time. They can affect quality of life and may be associated with other conditions such as asthma and eczema.
- From Development to Aging and Disease: Allergies can impact various stages of life, from childhood to old age, and may influence the development of other immune-related diseases.
