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Recombinant Proteins
Product List
Der P1
Der P1 Protein Recombinant
This recombinant protein, derived from E. coli, consists of the Dermatophagoides pteronyssinus Dust Mite Der P1 protein (amino acids 20-320) with a C-terminal 6-His tag. It has a molecular weight of 34.5 kDa and an isoelectric point of 5.6.
Shipped with Ice Packs 
Fra e 1.0101
Allergen Fra e 1.0101 Recombinant
Recombinant Allergen Fra e 1.0101, produced in SF9 insect cells, is a glycosylated polypeptide with a molecular weight of 17,794 Daltons. It features a 10xHis tag at the N-terminus and is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT17330
Source
Sf9 insect cells.
Appearance
A clear, sterile-filtered solution.
PhI p 12
Pollen Allergen Phl p 12 Recombinant
Recombinant PhI p 12, produced in SF9 insect cells, is a glycosylated polypeptide chain with a calculated molecular mass of 15,607 Daltons. It is expressed with a 10xHis tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
PhI p 2
Pollen allergen Phl p 2 Recombinant
Recombinant Pollen allergen Phl p 2, synthesized in SF9 cells, is a glycosylated polypeptide with an estimated molecular weight of 14,734 Daltons. This protein is engineered to include a 10xHis tag at its N-terminus and is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT18049
Source
Sf9 insect cells.
Appearance
A clear, sterile-filtered solution.
PhI p 5
Group V allergen Phl p 5.0203 Recombinant
Recombinant Group V allergen Phl p 5.0203, expressed in SF9 cells, is a glycosylated polypeptide chain with a calculated molecular mass of 27,582 Daltons. This protein is engineered with a 10xHis tag at its N-terminus and undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT18120
Source
Sf9 insect cells.
Appearance
The product is a sterile-filtered, clear solution.
PhI p 6
Pollen allergen Phl p 6 Recombinant
Recombinant Pollen allergen Phl p 6, produced in SF9 cells, is a glycosylated polypeptide chain with a calculated molecular mass of 13,162 Daltons. It is expressed with a 10xHis tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT18211
Source
Sf9 insect cells.
Appearance
A clear, sterile-filtered solution.
Phospholipase A2
Phospholipase A2 P00630 Bee Venom Protein Recombinant
This recombinant protein, derived from E. coli, encompasses amino acids 26-162 of the bee venom phospholipase P00630 protein. It includes a C-terminal 6xHis tag for purification purposes.
Shipped with Ice Packs
Polcalcin Phl p 7
Pollen Allergen Phl p 7 Recombinant
Recombinant Polcalcin Phl p 7, produced in SF9 cells, is a glycosylated polypeptide chain with a calculated molecular mass of 9.0 kDa. The purification process of Polcalcin Phl p 7 involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT18369
Source
Sf9 insect cells.
Appearance
A clear solution that has undergone sterile filtration.
Soybean P34
Soybean P34 Protein Recombinant
The recombinant Soybean P34 protein, derived from E. coli, encompasses the full length of the protein and has a molecular weight of 30 kDa. A His tag is fused to the C-terminus of the protein.
Shipped with Ice Packs
Cat. No.
BT18442
Source
E.Coli.
Appearance
The product is a sterile-filtered, colorless solution.
Soybean P34 GST
Soybean P34 Protein Recombinant, GST Tag
This recombinant protein, expressed in E. coli, comprises a 36kDa GST tag fused with Soybean P34 protein epitopes spanning amino acids 214-261 and 351-379.
Shipped with Ice Packs
Introduction
Definition and Classification
Allergy is an immune system response to a foreign substance (allergen) that is not typically harmful to the body. These foreign substances can include pollen, pet dander, certain foods, and insect stings. Allergies are classified into several types based on the mechanism of the immune response:
- Type I (Immediate Hypersensitivity): Mediated by IgE antibodies, leading to reactions such as hay fever, asthma, and anaphylaxis.
- Type II (Cytotoxic Hypersensitivity): Involves IgG or IgM antibodies targeting cells, leading to conditions like hemolytic anemia.
- Type III (Immune Complex Hypersensitivity): Involves immune complexes that deposit in tissues, causing conditions like systemic lupus erythematosus.
- Type IV (Delayed-Type Hypersensitivity): Mediated by T cells, leading to reactions such as contact dermatitis and tuberculin reactions.
Biological Properties
- Key Biological Properties: Allergies involve the immune system’s overreaction to harmless substances. Key players include IgE antibodies, mast cells, basophils, and various cytokines.
- Expression Patterns: IgE antibodies are produced by B cells and are specific to particular allergens. Mast cells and basophils express high-affinity IgE receptors (FcεRI).
- Tissue Distribution: Mast cells are found in connective tissues, particularly near blood vessels and nerves, while basophils circulate in the blood.
Biological Functions
- Primary Biological Functions: The primary function of the allergic response is to protect the body from perceived threats. This involves the release of histamines and other mediators that cause inflammation and other symptoms.
- Role in Immune Responses: Allergies play a role in immune responses by activating various immune cells and mediators.
- Pathogen Recognition: Although allergies are typically responses to non-pathogenic substances, the mechanisms involved are similar to those used in pathogen recognition.
Modes of Action
- Mechanisms with Other Molecules and Cells: Allergens bind to IgE antibodies on the surface of mast cells and basophils, leading to cell activation and degranulation.
- Binding Partners: Key binding partners include IgE antibodies, FcεRI receptors, and allergens.
- Downstream Signaling Cascades: Activation of mast cells and basophils leads to the release of histamines, leukotrienes, and other inflammatory mediators, triggering symptoms like itching, swelling, and bronchoconstriction.
Regulatory Mechanisms
- Regulatory Mechanisms: The expression and activity of IgE and other molecules involved in allergic responses are tightly regulated by various factors.
- Transcriptional Regulation: Genes encoding IgE and FcεRI are regulated by transcription factors such as NF-κB.
- Post-Translational Modifications: Post-translational modifications, such as phosphorylation, play a role in the activation and function of immune cells involved in allergies.
Applications
- Biomedical Research: Understanding allergies helps in developing treatments and preventive measures.
- Diagnostic Tools: Skin prick tests, blood tests for specific IgE, and challenge tests are used to diagnose allergies.
- Therapeutic Strategies: Treatments include antihistamines, corticosteroids, and immunotherapy (allergy shots).
Role in the Life Cycle
- Throughout the Life Cycle: Allergies can develop at any age and may change over time. They can affect quality of life and may be associated with other conditions such as asthma and eczema.
- From Development to Aging and Disease: Allergies can impact various stages of life, from childhood to old age, and may influence the development of other immune-related diseases.
