Recombinant Proteins

p53
LBP
CEA
HLA
TCL
TTC
NPM
MAF
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LY9 Human

Lymphocyte Antigen 9 Human Recombinant

Recombinant human LY9 protein, produced in Sf9 Baculovirus cells, is a single glycosylated polypeptide chain containing 416 amino acids (48-454 aa). It has a molecular mass of 45.9 kDa and migrates at 40-57 kDa on SDS-PAGE under reducing conditions. LY9 is expressed with a 6 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT3954
Source
Sf9, Baculovirus cells.
Appearance
A clear, colorless solution that has been sterilized by filtration.

LY6G6F Human

Lymphocyte Antigen 6 Complex Locus G6F Human Recombinant

Recombinant human LY6G6F, produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 242 amino acids (17-235) and has a molecular weight of 26.2 kDa. A 23 amino acid His-tag is fused to the N-terminus of LY6G6F, which is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT3813
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

LY86 Human

Lymphocyte Antigen 86 Human Recombinant

This product consists of a single chain of 165 amino acids (specifically, positions 21 to 162), representing the LY86 protein. Produced recombinantly in E. coli, it is non-glycosylated and has a molecular weight of 18.1 kDa. For purification and detection purposes, a 23 amino acid His-tag is attached to the N-terminus.
Shipped with Ice Packs
Cat. No.
BT3878
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized by filtration.
Definition and Classification

Lymphocyte antigens are molecules, often proteins, located on the surface of lymphocytes, which are a type of white blood cell. These antigens play a crucial role in the immune system by helping to identify and respond to foreign substances, such as pathogens. Lymphocytes are classified into three main types: B lymphocytes (B cells), T lymphocytes (T cells), and natural killer (NK) cells .

Biological Properties

Key Biological Properties: Lymphocyte antigens are highly specific molecules that can bind to particular antigens. They are essential for the immune system’s ability to recognize and respond to pathogens .

Expression Patterns: Lymphocyte antigens are expressed on the surface of lymphocytes. Each lymphocyte produces its own specific receptor that corresponds to a specific antigen .

Tissue Distribution: Lymphocytes are found in various tissues, including the blood, lymph nodes, spleen, thymus, and other lymphoid tissues .

Biological Functions

Primary Biological Functions: Lymphocyte antigens are involved in the recognition and binding of foreign substances, leading to the activation of immune responses . B cells produce antibodies, T cells directly attack infected cells, and NK cells destroy damaged or abnormal cells .

Role in Immune Responses: Lymphocyte antigens are critical for both humoral and cell-mediated immunity. They help the immune system remember previous encounters with pathogens, leading to a quicker and more effective response upon re-exposure .

Pathogen Recognition: Lymphocyte antigens detect foreign proteins on pathogens, triggering the production of antibodies and other immune responses .

Modes of Action

Mechanisms with Other Molecules and Cells: Lymphocyte antigens interact with other immune cells and molecules to coordinate the immune response. For example, T cells require antigen presentation by other cells to become activated .

Binding Partners: Lymphocyte antigens bind to specific receptors on the surface of pathogens or infected cells .

Downstream Signaling Cascades: Upon binding to their specific antigens, lymphocyte antigens initiate signaling cascades that lead to the activation and proliferation of immune cells .

Regulatory Mechanisms

Control of Expression and Activity: The expression and activity of lymphocyte antigens are tightly regulated by various mechanisms, including transcriptional regulation and post-translational modifications .

Transcriptional Regulation: Genes encoding lymphocyte antigens are regulated at the transcriptional level to ensure appropriate expression in response to immune challenges .

Post-Translational Modifications: Lymphocyte antigens undergo post-translational modifications, such as phosphorylation, to modulate their activity and interactions with other molecules .

Applications

Biomedical Research: Lymphocyte antigens are widely studied in biomedical research to understand immune responses and develop new therapies .

Diagnostic Tools: They are used in diagnostic assays to detect immune responses and diagnose infections and autoimmune diseases .

Therapeutic Strategies: Targeting lymphocyte antigens is a promising approach in immunotherapy for treating cancers and autoimmune diseases .

Role in the Life Cycle

Development: Lymphocyte antigens are essential for the development and maturation of lymphocytes in the bone marrow and thymus .

Aging and Disease: The function of lymphocyte antigens can decline with age, leading to increased susceptibility to infections and diseases . They also play a role in the development of autoimmune diseases and cancers .

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