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Recombinant Proteins
Product List
OLR1 Human, HEK
Oxidized Low Density Lipoprotein Receptor 1 Human Recombinant, HEK
Produced in HEK cells, recombinant human OLR1 is a single, glycosylated polypeptide chain with a sequence spanning from Ser61 to Gln273. This sequence encompasses 221 amino acids, resulting in a calculated molecular mass of 25.3 kDa. The protein also includes an 8 amino acid Flag tag fused to its N-terminus.
Shipped with Ice Packs 
Cat. No.
BT29833
Source
HEK 293.
Appearance
The product appears as a white, lyophilized powder after filtration.
OLR1 Human, Sf9
Oxidized Low Density Lipoprotein Receptor 1 Human Recombinant, Sf9
Recombinant human OLR1, produced in Sf9 insect cells using a baculovirus expression system, is a single, glycosylated polypeptide chain. This protein consists of 225 amino acids (residues 58-273), resulting in a molecular mass of 25.8 kDa. Note that the apparent molecular size on SDS-PAGE may range from 28 to 40 kDa. The OLR1 protein is tagged with a 6-amino acid His-tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29885
Source
Sf9,
Baculovirus cells.
Appearance
A clear, colorless solution that has been sterilized by filtration.
LRPAP1 Mouse
Low Density Lipoprotein Receptor Related Protein Associated Protein 1 Mouse Recombinant
Recombinant LRPAP1 from mouse has been produced in E. coli. This non-glycosylated polypeptide chain consists of 355 amino acids (29-360 a.a), resulting in a molecular weight of 41.4 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified through proprietary chromatographic methods.
Shipped with Ice Packs
OLR1 Human
Oxidized Low Density Lipoprotein Receptor 1 Human Recombinant
Recombinant human OLR1, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 216 amino acids (residues 58-273). It has a molecular weight of 24.7 kDa. OLR1 undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29728
Source
E.coli.
Appearance
Clear, colorless solution, sterile-filtered.
HDL Human
High Density Lipoprotein Human
Human High Density Lipoprotein (HDL) is derived from human plasma.
Shipped with Ice Packs
Cat. No.
BT29381
Source
Human plasma.
Appearance
The appearance of the liquid varies from yellow to orange.
LDL Human
Low-Density Lipoprotein Human
Human Low Density Lipoprotein (LDL) isolated from human plasma.
Shipped with Ice Packs
Cat. No.
BT29441
Source
Human plasma.
Appearance
Liquid with a color ranging from yellow to orange.
LDLRAP1 Human
Low Density Lipoprotein Receptor Adaptor Protein 1 Human Recombinant
Recombinant LDLRAP1, produced in E.coli, is a single polypeptide chain that is not glycosylated. It consists of 328 amino acids, specifically amino acids 1 to 308, and has a molecular weight of 36.1 kDa. For purification purposes, a 20 amino acid His-tag is attached to the N-terminus of the protein. The protein is further purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29524
Source
E.coli.
Appearance
The solution is sterile, filtered, and colorless.
LRPAP1 Human
Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 Human Recombinant
Recombinant human LRPAP1, produced in E. coli, is a non-glycosylated polypeptide chain containing 348 amino acids (residues 35-357) with a molecular weight of 40.4 kDa. This protein is expressed with a 25 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29608
Source
E.coli.
Appearance
Clear, colorless solution, sterile-filtered.
Introduction
Definition and Classification
Density lipoproteins are complex particles composed of lipids and proteins that transport lipids through the bloodstream. They are classified based on their density and size into several types:
- Chylomicrons: The largest and least dense, primarily transport dietary triglycerides and cholesterol from the intestines to other tissues.
- Very Low-Density Lipoproteins (VLDL): Transport triglycerides from the liver to peripheral tissues.
- Intermediate-Density Lipoproteins (IDL): Formed from the degradation of VLDL, they are intermediate in size and density.
- Low-Density Lipoproteins (LDL): Known as “bad cholesterol,” they transport cholesterol to tissues but can lead to plaque formation in arteries.
- High-Density Lipoproteins (HDL): Known as “good cholesterol,” they transport cholesterol from tissues back to the liver for excretion.
Biological Properties
- Key Biological Properties: Density lipoproteins vary in lipid and protein composition, influencing their density and function. They contain apolipoproteins that serve as structural components and enzyme cofactors.
- Expression Patterns: The liver and intestines are primary sites for lipoprotein synthesis.
- Tissue Distribution: Lipoproteins circulate in the bloodstream, delivering lipids to various tissues, including adipose tissue, muscle, and the liver.
Biological Functions
- Primary Biological Functions: Transport of triglycerides, cholesterol, and fat-soluble vitamins.
- Role in Immune Responses: HDL has anti-inflammatory and antioxidant properties, playing a role in immune regulation.
- Pathogen Recognition: Certain lipoproteins can bind to and neutralize pathogens, contributing to innate immunity.
Modes of Action
- Mechanisms with Other Molecules and Cells: Lipoproteins interact with cell surface receptors, such as LDL receptors, to deliver lipids into cells.
- Binding Partners: Apolipoproteins on lipoproteins bind to specific receptors and enzymes.
- Downstream Signaling Cascades: Binding of lipoproteins to receptors can trigger intracellular signaling pathways that regulate lipid metabolism and cellular uptake.
Regulatory Mechanisms
- Expression and Activity: Regulated by dietary intake, hormonal signals, and genetic factors.
- Transcriptional Regulation: Genes encoding apolipoproteins and lipoprotein receptors are regulated by transcription factors like SREBP (Sterol Regulatory Element-Binding Protein).
- Post-Translational Modifications: Lipoproteins undergo modifications such as glycosylation and proteolysis, affecting their function and clearance.
Applications
- Biomedical Research: Studying lipoproteins helps understand cardiovascular diseases and metabolic disorders.
- Diagnostic Tools: Measuring levels of LDL and HDL cholesterol is crucial for assessing cardiovascular risk.
- Therapeutic Strategies: Targeting lipoprotein metabolism with drugs like statins and PCSK9 inhibitors to lower LDL cholesterol levels.
Role in the Life Cycle
- Development to Aging and Disease: Lipoprotein levels and composition change throughout life. Elevated LDL levels are associated with atherosclerosis and cardiovascular diseases, while HDL levels are protective. Age-related changes in lipoprotein metabolism can influence disease risk.
