Recombinant Proteins

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TGFBI Human

Transforming Growth Factor Beta Induced Human Recombinant

Recombinant Human TGFBI, produced in E. coli, is a non-glycosylated polypeptide chain comprising 135 amino acids (spanning positions 502-636). With a molecular weight of 14.5 kDa, this protein variant is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15782
Source
Escherichia Coli.
Appearance
Sterile, filtered liquid solution.

TGFBI Human, 182 a.a.

Transforming Growth Factor Beta-Induced (182 a.a.) Human Recombinant

Recombinant Human TGFBI, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 182 amino acids (502-683). It has a molecular mass of 19.9 kDa. However, its apparent molecular weight on SDS-PAGE might be higher. The purification process of this recombinant human TGFBI protein involves proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT15887
Source
Escherichia Coli.
Appearance
Sterile, filtered liquid solution.

TGFBRAP1 Human

Transforming Growth Factor Beta Receptor Associated Protein 1 Human Recombinant

Recombinant human TGFBRAP1, expressed in E. coli, is a non-glycosylated polypeptide chain. It consists of 296 amino acids (residues 601-860) and has a molecular weight of 33 kDa. This protein includes a 36 amino acid His-tag at the N-terminus. Purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15955
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized by filtration.

TGIF2LX Human

TGFB-Induced Factor Homeobox 2-Like, X-Linked Human Recombinant

Recombinant human TGIF2LX, expressed in E. coli, is a single polypeptide chain with a molecular weight of 29.1 kDa. The protein consists of 264 amino acids, including amino acids 1-241 of the TGIF2LX sequence, and a 23 amino acid His-tag fused to the N-terminus. Purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16031
Source
Escherichia Coli.
Appearance
A clear solution that has undergone sterile filtration.

TGIF2LY Human

TGFB-Induced Factor Homeobox 2-Like Y-Linked Human Recombinant

Recombinant human TGIF2LY, expressed in E. coli, is a single polypeptide chain comprising 208 amino acids (1-185) with a molecular weight of 23.2 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16130
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.
Definition and Classification

Transforming Growth Factor Beta Induced (TGFBI), also known as βig-H3, is an extracellular matrix protein induced by Transforming Growth Factor Beta (TGF-β). TGFBI is part of the TGF-β superfamily, which includes various cytokines involved in cellular processes such as proliferation, differentiation, and apoptosis .

Biological Properties

Key Biological Properties: TGFBI is a multifunctional protein that plays a role in cell adhesion, migration, and differentiation. It is involved in various physiological and pathological processes, including wound healing, fibrosis, and cancer .

Expression Patterns: TGFBI is expressed in a wide range of tissues, including the cornea, skin, and various internal organs. Its expression is regulated by TGF-β and other cytokines .

Tissue Distribution: TGFBI is found in the extracellular matrix of many tissues, where it interacts with other matrix proteins and cell surface receptors to mediate its effects .

Biological Functions

Primary Biological Functions: TGFBI plays a crucial role in maintaining tissue homeostasis by regulating cell adhesion, migration, and differentiation. It is also involved in the formation of the extracellular matrix and tissue remodeling .

Role in Immune Responses: TGFBI modulates immune responses by influencing the activity of various immune cells, including macrophages and T cells. It can act as both an immune suppressor and an immune activator, depending on the context .

Pathogen Recognition: TGFBI has been shown to play a role in pathogen recognition by binding to microbial components and facilitating their clearance by immune cells .

Modes of Action

Mechanisms with Other Molecules and Cells: TGFBI interacts with various cell surface receptors, including integrins and TGF-β receptors, to mediate its effects. These interactions trigger downstream signaling cascades that regulate cellular responses .

Binding Partners: TGFBI binds to several extracellular matrix proteins, such as collagen and fibronectin, as well as cell surface receptors like integrins .

Downstream Signaling Cascades: Upon binding to its receptors, TGFBI activates multiple signaling pathways, including the Smad and MAPK pathways, which regulate gene expression and cellular functions .

Regulatory Mechanisms

Expression and Activity Control: The expression of TGFBI is tightly regulated by TGF-β and other cytokines. Transcriptional regulation involves various transcription factors, including Smad proteins .

Transcriptional Regulation: TGFBI gene expression is controlled by TGF-β signaling through the activation of Smad2/3 transcription factors, which bind to the promoter region of the TGFBI gene .

Post-Translational Modifications: TGFBI undergoes several post-translational modifications, including phosphorylation and glycosylation, which are essential for its stability and function .

Applications

Biomedical Research: TGFBI is a valuable target in biomedical research due to its involvement in various diseases, including cancer, fibrosis, and corneal dystrophies .

Diagnostic Tools: TGFBI levels can serve as biomarkers for certain diseases, such as cancer and fibrosis, aiding in diagnosis and prognosis .

Therapeutic Strategies: Targeting TGFBI and its signaling pathways holds potential for developing new therapeutic strategies for diseases like cancer, fibrosis, and inflammatory disorders .

Role in the Life Cycle

Development: TGFBI plays a critical role in embryonic development by regulating cell differentiation and tissue formation .

Aging: During aging, TGFBI expression and function may be altered, contributing to age-related tissue degeneration and diseases .

Disease: Dysregulation of TGFBI is associated with various diseases, including cancer, fibrosis, and corneal dystrophies. It can act as both a tumor suppressor and a tumor promoter, depending on the context .

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