Recombinant Proteins
Product List
NFKBIA Human
NF-kappa-B Inhibitor Alpha Human Recombinant
NFKBIB Human
NF-kappa-B Inhibitor Beta Human Recombinant
NFKBID Human
NF-kappa-B Inhibitor Delta Human Recombinant
NKIRAS1 Human
NFKB Inhibitor Interacting Ras-Like 1 Human Recombinant
NKIRAS2 Human
NFKB Inhibitor Interacting Ras-Like 2 Human Recombinant
Introduction
NFKB inhibitors are molecules that inhibit the activity of the nuclear factor kappa B (NF-κB) pathway, a critical regulator of immune responses, inflammation, and cell survival. These inhibitors can be classified into several categories based on their mechanism of action:
- Direct inhibitors: These bind directly to NF-κB proteins, preventing their activation.
- Indirect inhibitors: These target upstream signaling molecules that activate NF-κB, such as IκB kinase (IKK).
- Natural inhibitors: Compounds derived from natural sources, such as curcumin and resveratrol, which have been shown to inhibit NF-κB activity .
Key Biological Properties: NF-κB inhibitors play a crucial role in modulating immune responses and inflammation. They are involved in the regulation of genes responsible for cytokine production, cell proliferation, and apoptosis . Expression Patterns and Tissue Distribution: NF-κB inhibitors are expressed in various tissues, including the immune system, liver, and brain. Their expression can be induced by inflammatory stimuli, stress, and infections .
Primary Biological Functions: The primary function of NF-κB inhibitors is to regulate the NF-κB signaling pathway, which is essential for immune responses, inflammation, and cell survival . Role in Immune Responses and Pathogen Recognition: NF-κB inhibitors modulate the immune response by controlling the expression of cytokines and other immune-related genes. They play a critical role in pathogen recognition and the subsequent activation of immune responses .
Mechanisms with Other Molecules and Cells: NF-κB inhibitors interact with various molecules and cells to modulate the NF-κB pathway. They can inhibit the phosphorylation and degradation of IκB proteins, preventing the activation of NF-κB . Binding Partners and Downstream Signaling Cascades: NF-κB inhibitors bind to specific proteins in the NF-κB pathway, such as IκBα, to prevent their degradation. This inhibition blocks the downstream signaling cascades that lead to the activation of NF-κB .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of NF-κB inhibitors are tightly regulated by various mechanisms, including transcriptional regulation and post-translational modifications . Transcriptional Regulation and Post-Translational Modifications: NF-κB inhibitors are regulated at the transcriptional level by various transcription factors. Post-translational modifications, such as phosphorylation and ubiquitination, also play a crucial role in controlling their activity .
Biomedical Research: NF-κB inhibitors are widely used in biomedical research to study the role of the NF-κB pathway in various diseases, including cancer, inflammatory disorders, and neurodegenerative diseases . Diagnostic Tools and Therapeutic Strategies: NF-κB inhibitors have potential applications as diagnostic tools and therapeutic agents. They are being investigated for their ability to reduce inflammation, modulate immune responses, and enhance the efficacy of chemotherapy and radiation therapy .
Role Throughout the Life Cycle: NF-κB inhibitors play a role throughout the life cycle, from development to aging and disease. They are involved in the regulation of immune responses, inflammation, and cell survival at various stages of life . From Development to Aging and Disease: During development, NF-κB inhibitors help regulate immune system maturation and function. In aging, they play a role in controlling inflammation and preventing age-related diseases. In disease, NF-κB inhibitors are involved in modulating immune responses and inflammation .
