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Recombinant Proteins

Melanoma Antigen Family A

Calcium Binding Protein

Dynactin

Killer Cell Lectin-like Receptor

Other

Dynein Light Chain

SNRP

Kirsten Rat Sarcoma Viral Oncogene

Dysbindin

Kruppel-Like Factor

Ectodysplasin

Elongator Acetyltransferase Complex

Endothelial Cell-Specific Molecule 1

Endoplasmic Reticulum Protein

Solute Carrier Family

Lactoferrin

EPH Receptor

Sorting Nexin

Calcyphosine

Leukocyte Cell Derived Chemotaxin

RAN Binding Protein

Calmodulin

Outer Membrane Protein

Ephrin

p53

sRAGE

Leukocyte-Associated Ig-Like Receptor

Paired Box

Parkinson Disease Protein

SPSB

LIN Protein

Parvalbumin

PCNA

SPARC

PDZ Domain Containing

LBP

Calpain

Calponin

Pentraxin

SRY (Sex Determining Region Y)-Box

Calreticulin

Eukaryotic Translation Initiation Factor

Peroxisomal Biogenesis Factor

Listeriolysin

Stathmin

PHD Finger Protein

LRG1

Calumenin

Phosducin-Like

Streptavidin Proteins

Candida Albicans

Phosphatase and Tensin

Lymphocyte Antigen

PITPN

Canopy FGF Signaling Regulator

Lysosomal-Associated Membrane Protein

Phospholipid Scramblase

STIP

Capping Protein

PIH1 Domain Containing

Pim Oncogene

SDHAF

CEA

Polymerase (RNA) (DNA directed) Polypeptide

MAD2

Superoxide Dismutase

Mago-Nashi Homolog

HLA

KCTD

Caspase Recruitment Domain Family

CEBP

Surfeit

POU Class

Synaptobrevin

ERCC

CCR4-NOT Transcription Complex

Exosome Component

Maltose Binding Protein

Prefoldin

Cell Division Cycle

Mediator Complex

FABP

Synaptosomal Associated Protein

Pregnancy Specific Beta-1-Glycoprotein

Cellular Retinoic Acid Binding Protein

Centrin

Synaptotagmin

Member RAS Oncogene Family

Centromere Protein

Prion Protein

Processing Of Precursor

Syndecan

Profilin

Charged Multivesicular Body Protein

Programmed Cell Death

Chloride Intracellular Channel

Family with Sequence Similarity

Chromatin Modifying Protein

Synovial Sarcoma, X Breakpoint

Chromobox

Prohibitin

Syntaxin

F-Box Protein

Proprotein Convertase Subtilisin/Kexin

Chromogranin

Protein C-Ets

Ferritin

Protein Phosphatase

Fibrinogen

Protein-A, A/G & G

Chromosome Open Reading Frame

Fibronectin Type III Domain Containing

Synuclein

Folate Receptor

Four And A Half LIM

Fragile Histidine Triad

G Antigen

GABA(A) Receptor-Associated Protein

Gastrokine

Tachykinin

TAR DNA

Clathrin

GDP Dissociation Inhibitor

Prothymosin

Coagulation Factors

General Transcription Factor

RAD51

TBC1 Domain Family

RASSF

TCL

Ras-Related C3 Botulinum Toxin Substrate

GIPC PDZ Domain

Cofilin

TTC

Gliadin

Mesoderm Development Candidate

Coiled-Coil Domain

Receptor Activity-Modifying Protein

Met Proto-Oncogene

Glycophorin

Toll Like Receptor

Methylmalonic Aciduria

Regenerating Islet-Derived

THAP Domain

MHC class I chain-related gene

Glycoprotein Nmb

Collagen

Thioredoxin

Glypican

Microfibrillar Associated Protein

Actin

Regulator of Calcineurin

Gremlin

Regulator of G-Protein Signaling

Microtubule-Associated Protein

GTPase IMAP Family

Adaptor-Related Protein Complex

GTP-Binding Protein

Guanine Nucleotide Binding Protein

ADP-Ribosylation Factor

Related RAS Viral (r-ras) Oncogene

COMM Domain Containing

TIGAR

Mitochondrial Ribosomal Protein

Relaxin

Hairy and Enhancer of Split

Tissue Factor Pathway Inhibitor

Renin

Complement Component

Haptoglobin

TNF receptor-Associated Factor

Mitochondrial Transcription Factor

Reticulocalbin

Trafficking Protein Particle Complex

Heat Shock Protein

MOB1, Mps One Binder Kinase Activator

Retinoblastoma

Mortality Factor

Myelin Basic Protein

Retinoic Acid Early Transcript

Myelin Oligodendrocyte Glycoprotein

Transcription Elongation Factor

Myoglobin

Ag85

Retinoic Acid Receptor Responder

Albumin

Myosin Light Chain

Rho Family GTPase

Transferrin

Rho GDP Dissociation Inhibitor

Allergy

Ribosomal Protein

Transforming Growth Factor Beta Induced

Transgelin

Myxovirus

Translocase Of Outer Mitochondrial Membrane

NANOG

Troponin

NCK Adaptor Protein

Junctional Adhesion Molecule

Nescient Helix Loop Helix

NECTIN

Neuronal Calcium Sensor

Neutrophil Cytosolic Factor

NFKB Inhibitor

Ring Finger Protein

Triggering Receptor Expressed on Myeloid Cells

NHP2

Tripartite Motif

Alpha-2-HS-Glycoprotein

RNA Binding Motif Protein

Tropomyosin

Anaplasma

COP9 Signalosome

N-Myc Downstream Regulated

R-Spondin

Ankyrin Repeat Domain

C-Reactive Protein

TROVE Domain Family

Non-Metastatic Cells

RWD Domain Containing

Sclerostin

Hematological And Neurological Expressed

Angiogenin

Hemoglobin

Annexin

Trypsin

Secretagogin

Crystallin

Tubulin Folding Cofactor

Secreted Frizzled-Related Protein

NTF2-like Export Factor

Nucleobindin

Hemopexin

U6 Small Nuclear RNA

NPM

HNRNP

Nucleopurin

Secretoglobin

Nucleosome Assembly Protein

High-Mobility Group

Secretogranin

Tubulin Gamma

Orosomucoid

Selectin

Ubiquinol-Cytochrome C Reductase

Anterior Gradient Protein

Ubiquitin

ASF1 Anti-Silencing Function 1

HINT

C-type Lectin Domain

ATP Synthase Mitochondrial

Homeobox

Selenoprotein

ATPase

Septin

Serglycin

Homer Homolog

Serine Peptidase Inhibitor

Autophagy Related

Hypoxia-Inducible Factor

Serpin

Bartonella H.

Ig Heavy Chain Constant Region

CUE Domain Containing

B Cell Lymphoma

Cystatin

UCHL1

IMPAD1

UL16 binding protein

Inhibitor of DNA Binding

Uroplakin

Inhibitor of Growth Family

Integrin

Vacuolar Protein Sorting

Intercellular Adhesion Molecule

Vascular cell adhesion molecule

B9 Protein

SERTA Domain Containing

Babesia Microti

SH2 Domain

V-crk Sarcoma Virus CT10

SH3 Domain

Baculoviral IAP Repeat-Containing

Vimentin

Karyopherin

Visinin-Like Protein

BATF

Cysteine-Rich

Killer Cell

Basic Transcription Factor

MAF

SIGLEC

Cysteine-Rich Secretory Protein

Bax

V-ral Simian Leukemia Viral Oncogene

Beta 2 Microglobulin

Cytochrome

WAP Four-Disulfide Core Domain

Signal Recognition Particle

BID

Y. Enterocolitica

Signal Sequence Receptor

Biglycan

Signal-Regulatory Protein

Cytohesin

Bromodomain Containing

Zinc Finger

Cadherin

Cytokeratin

Single-Stranded DNA Binding Protein

Sirtuin

Bridging Integrator

SIX Homeobox

Calbindin

SLAM Family

SMAD

DCUN1D

DEAD Box Protein

Decorin

Density Lipoprotein

Developmental Pluripotency Associated

Dickkopf-Related Protein

DiGeorge Syndrome Critical Region

DNA-Damage Protein

Transmembrane Proteins

FC Receptor

Cancer Targets

Immune Checkpoint

CAR-T Cell Therapy Targets

Product List

MAGEA3 Human

Melanoma Antigen Family A, 3 Human Recombinant

MAGEA3, a single, non-glycosylated polypeptide chain produced in E. coli, has 337 amino acids (1-314 a.a.) and a molecular weight of 37.1 kDa. A 23-amino acid His-tag is fused to the N-terminus of MAGEA3, which is then purified using proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT6143

Source

Escherichia Coli.

Appearance

A clear, sterile solution.

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MAGEB10 Human

Melanoma Antigen Family B,10 Human Recombinant

Recombinant human MAGEB10, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 370 amino acids (residues 1-347) with a molecular weight of 41.4 kDa. It includes a 23-amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT6534

Source

Escherichia Coli.

Appearance

A clear solution, sterilized by filtration.

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MAGED1 Human

Melanoma Antigen Family D, 1 Human Recombinant

Recombinant human MAGED1, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 280 amino acids (residues 504-760). With a molecular weight of 31.7 kDa, this protein comprises amino acids 504 to 760 of the MAGED1 sequence. A 23-amino acid His-tag is fused to the N-terminus of the protein. Purification is achieved using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT6628

Source

E.coli.

Appearance

The product appears as a clear, colorless solution that has been sterilized by filtration.

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MAGEA6 Human

Melanoma Antigen Family A, 6 Human Recombinant

Recombinant MAGEA6, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 322 amino acids (1-314 a.a.) with a molecular mass of 35.9 kDa. It includes an 8 amino acid His-tag at the C-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT6384

Source

E.coli.

Appearance

A clear, colorless solution that has been sterilized by filtration.

View Details

MAGEA8 Human

Melanoma Antigen Family A, 8 Human Recombinant

Recombinant human MAGEA8, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 341 amino acids (residues 1-318) with a molecular weight of 37.6 kDa. The protein includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT6450

Source

Escherichia Coli.

Appearance

A clear solution, sterilized by filtration.

View Details

MAGEA4 Human

Melanoma Antigen Family A, 4 Human Recombinant

Recombinant Human MAGEA4, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 337 amino acids (1-317 a.a.). With a molecular weight of 37 kDa, this protein includes a 20 amino acid His-Tag fused at the N-terminus. Purification is achieved through proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT6215

Source

Escherichia Coli.

Appearance

A clear, colorless solution that has been sterilized by filtration.

View Details

MAGEA5 Human

Melanoma Antigen Family A, 5 Human Recombinant

Recombinant MAGEA5, produced in E. coli, is a single polypeptide chain comprising 148 amino acids (residues 1-124) with a molecular weight of 15.6 kDa. The protein includes a 24 amino acid His-tag fused at the N-terminus to facilitate purification using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT6319

Source

E.coli.

Appearance

The product is a clear and colorless solution that has been sterilized by filtration.

View Details

Introduction

Definition and Classification

The Melanoma Antigen Family A (MAGE-A) is a subgroup of the larger Melanoma Antigen Gene (MAGE) family, which belongs to the cancer/testis (CT) antigen group. These antigens are characterized by their restricted expression in immune-privileged tissues such as the testis and various cancers. MAGE-A proteins are presented on the cell surface by MHC class I molecules, making them potential targets for cancer immunotherapy.

Biological Properties

Key Biological Properties: MAGE-A proteins share a conserved MAGE homology domain (MHD), which is highly conserved within the subfamily.

Expression Patterns: MAGE-A proteins exhibit restricted expression in reproductive tissues but are abnormally expressed in various human malignancies.

Tissue Distribution: These proteins are primarily found in germline cells and a wide range of cancers, including bladder cancer, where they are associated with increased cancer cell proliferation, survival, and resistance to therapies.

Biological Functions

Primary Biological Functions: MAGE-A proteins play a crucial role in tumorigenesis and cancer cell survival. They are involved in driving cancer progression, metastasis, and therapeutic recurrence.

Role in Immune Responses: MAGE-A proteins are recognized by cytotoxic T lymphocytes, which induce a robust immune response against developing cancer cells.

Pathogen Recognition: While primarily involved in cancer, MAGE-A proteins also contribute to immune responses by presenting unique cancer epitopes on the cell surface.

Modes of Action

Mechanisms with Other Molecules and Cells: MAGE-A proteins interact with various molecules and cells through their presentation on MHC class I molecules.

Binding Partners: They bind to cytotoxic T lymphocytes, facilitating the immune response against cancer cells.

Downstream Signaling Cascades: The interaction of MAGE-A proteins with immune cells triggers downstream signaling cascades that lead to the destruction of cancer cells.

Regulatory Mechanisms

Transcriptional Regulation: The expression of MAGE-A genes is regulated by epigenetic mechanisms such as DNA methylation and histone modification.

Post-Translational Modifications: MAGE-A proteins undergo various post-translational modifications that influence their activity and stability.

Applications

Biomedical Research: MAGE-A proteins are extensively studied as biomarkers for cancer diagnosis and prognosis.

Diagnostic Tools: Their restricted expression in cancers makes them ideal targets for developing diagnostic assays.

Therapeutic Strategies: MAGE-A proteins are targeted in cancer immunotherapy, including cancer vaccines and adoptive T-cell transfer therapies.

Role in the Life Cycle

Development: MAGE-A proteins are involved in germ cell development and are expressed during spermatogenesis and embryonic development.

Aging and Disease: Their expression is typically silenced in normal adult tissues but reactivated in various cancers, contributing to cancer progression and resistance to therapies.