Recombinant Proteins

p53
LBP
CEA
HLA
TCL
TTC
NPM
MAF
Bax
BID

Prealbumin Human

Transthyretin Human

This product consists of a human transthyretin dimer protein, derived from human plasma. Its molecular weight is typically 30kD, but may present as a 15kD monomer or a 60kD tetramer under certain conditions.

Shipped with Ice Packs
Cat. No.
BT15399
Source

Human serum.

Appearance

This product comes in the form of a sterile, white powder that has been lyophilized (freeze-dried).

HSA Fatty Acid free

Human Serum Albumin Recombinant, Fatty Acid Free

Recombinant HSA (Human Serum Albumin), specifically the Fatty Acid reduced variant produced in plants, consists of 585 amino acids and has a molecular mass of 67 kDa. Purification of this recombinant albumin is achieved through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT14995
Source
Rice Grain.
Appearance
Sterile Filtered clear yellowish solution.

HSA Recombinant, HEK

Human Serum Albumin Recombinant, HEK

Recombinant Human Serum Albumin (HSA), produced in HEK cells, is a monomeric protein with a molecular weight ranging from 60 to 65 kDa due to glycosylation. The purification process involves specialized chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15075
Source
HEK.
Appearance
White, sterile-filtered powder obtained through freeze-drying.

HSA Recombinant, Plant

Human Serum Albumin Recombinant, Plant

Recombinant Human Serum Albumin (HSA) produced in plants is a non-glycosylated polypeptide chain. With a molecular weight of 67 kDa, it consists of 585 amino acids. For optimal cell culture applications, the recommended concentration of recombinant Albumin ranges from 0.5 grams to 2 grams per liter. The purification process for this recombinant Albumin involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15165
Source
Rice Grain.
Appearance
White, lyophilized powder, sterilized by filtration.

HSA, Pichia Pastoris

Human Serum Albumin Recombinant, Pichia

Recombinant HSA, produced using Pichia Pastoris (a type of yeast), is a protein chain composed of 585 amino acids. It has a molecular weight of 67 kDa.
The purification process of this recombinant albumin involves specialized chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT15231
Source
Pichia Pastoris.
Appearance

The solution has a gel-like consistency and a yellowish hue.

HSA, Sf9

Serum Albumin Human, Sf9

Recombinant HSA, expressed in Sf9 insect cells using a baculovirus system, is a single, glycosylated polypeptide chain consisting of amino acids 19 to 609. It also includes a 6-amino acid Histidine tag fused at the C-terminus, resulting in a total of 597 amino acids and a molecular weight of 68 kDa. When analyzed by SDS-PAGE under reducing conditions, HSA displays multiple bands between 50-70 kDa. The protein undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15300
Source
Sf9, Baculovirus cells.
Appearance
A clear and colorless solution that has been sterilized by filtration.

Transthyretin Human

Prealbumin Human Recombinant

Recombinant Human Transthyretin, expressed in E. coli, is a single, non-glycosylated polypeptide chain. This protein comprises 128 amino acids, spanning from amino acid positions 21 to 147, and exhibits a molecular weight of 13.8 kDa. The purification process for this Transthyretin involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15479
Source
Escherichia Coli.
Appearance
Clear, colorless solution that has been sterilized by filtration.
Definition and Classification

Albumin is a family of globular proteins, the most common of which are the serum albumins. These proteins are water-soluble, moderately soluble in concentrated salt solutions, and experience heat denaturation . Albumins are commonly found in blood plasma and differ from other blood proteins in that they are not glycosylated . Human serum albumin is the main protein of human blood plasma, making up around 50% of human plasma proteins .

Biological Properties

Key Biological Properties: Albumin is synthesized by hepatocytes in the liver and released into the bloodstream. It has a relatively long half-life, allowing it to perform its functions continuously . Albumin binds to water, cations (such as Ca2+, Na+, and K+), fatty acids, hormones, bilirubin, thyroxine (T4), and pharmaceuticals .

Expression Patterns and Tissue Distribution: Albumin is primarily synthesized in the liver and is found abundantly in blood plasma. It is also present in other body fluids and tissues .

Biological Functions

Primary Biological Functions: Albumin plays a crucial role in maintaining the osmotic balance between blood vessels and surrounding tissues, regulating the distribution of water, electrolytes, and other solutes . It also serves as a carrier protein, transporting various substances in the bloodstream .

Role in Immune Responses and Pathogen Recognition: Albumin exhibits antioxidant properties, scavenging free radicals and protecting against oxidative stress. It also plays a role in the immune response by binding and transporting various substances involved in the immune system .

Modes of Action

Mechanisms with Other Molecules and Cells: Albumin binds to a wide variety of molecules, including hormones, fatty acids, and drugs, facilitating their transport and delivery to different tissues and organs . It also acts as a blood plasma buffer, maintaining acid-base balance .

Binding Partners and Downstream Signaling Cascades: Albumin interacts with various binding partners, including calcium, thyroxine, cortisol, and testosterone . These interactions help regulate the availability and activity of these molecules in the body .

Regulatory Mechanisms

Control of Expression and Activity: The synthesis of albumin is regulated by hormonal factors such as insulin, cortisol, and growth hormone (GH), while pro-inflammatory mediators like interleukin (IL)-6 and tumor necrosis factor (TNF)-α inhibit its production .

Transcriptional Regulation and Post-Translational Modifications: Albumin is synthesized in the liver and undergoes various post-translational modifications that affect its function and stability .

Applications

Biomedical Research: Albumin is widely used in biomedical research due to its ability to bind and transport various substances. It is used as a standard in protein quantification assays and as a stabilizer in biochemical reactions .

Diagnostic Tools: Albumin levels in the blood are used as a diagnostic marker for liver and kidney function, nutritional status, and overall health .

Therapeutic Strategies: Albumin is used therapeutically to treat conditions such as hypoalbuminemia, hypovolemia, and ascites. It is also used in drug delivery systems to enhance the stability and bioavailability of therapeutic agents .

Role in the Life Cycle

Development to Aging and Disease: Albumin plays a vital role throughout the life cycle, from development to aging. It helps maintain fluid balance, transport essential molecules, and protect against oxidative stress. Changes in albumin levels can indicate various health conditions, including liver and kidney disease, malnutrition, and inflammation .

© Copyright 2024 Thebiotek. All Rights Reserved.