Recombinant Proteins

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OMG Human

Oligodendrocyte Myelin Glycoprotein Recombinant Human

Recombinant human OMG protein, expressed in Sf9 insect cells using a baculovirus system, is a single, glycosylated polypeptide chain. It consists of 401 amino acids (residues 25-418), with an 8-amino acid His-tag at the C-terminus. The molecular weight of the protein is 45.4 kDa, but it appears as a band at approximately 50-100 kDa on SDS-PAGE due to glycosylation. Purification is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT14809
Source
Sf9, Baculovirus cells.
Appearance
The product is a clear solution that has been sterilized by filtration.

MOG

Myelin Oligodendrocyte Glycoprotein

Myelin Oligodendrocyte Glycoprotein is a single, non-glycosylated polypeptide chain composed of 21 amino acids. It has a molecular weight of 2581 Daltons and the molecular formula C118H177N35O29S.
Shipped with Ice Packs
Cat. No.
BT14434
Appearance
The product appears as a sterile, white powder that has been freeze-dried.

MOG Human

Myelin Oligodendrocyte Glycoprotein Human Recombinant

This product consists of a single, non-glycosylated polypeptide chain of Myelin Oligodendrocyte Glycoprotein (MOG) produced in E. coli. It contains 132 amino acids, including amino acids 30-154 of MOG and a 6x His tag at the C-terminus. The molecular weight of the protein is 15.2 kDa.
Shipped with Ice Packs
Cat. No.
BT14487
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

MPZL1 Human

Myelin Protein Zero-Like 1 Human Recombinant

Recombinant Human MPZL1, produced in E. coli, is a single, non-glycosylated polypeptide chain encompassing amino acids 38-162. It has a molecular weight of 16.1 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT14542
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
Definition and Classification

Myelin Oligodendrocyte Glycoprotein (MOG) is a glycoprotein that is part of the myelin sheath, which insulates nerve fibers in the central nervous system (CNS). It is encoded by the MOG gene located on chromosome 6 in humans . MOG is a member of the immunoglobulin superfamily and is expressed on the outermost surface of myelin sheaths and oligodendrocyte membranes .

Biological Properties

Key Biological Properties: MOG is believed to play a crucial role in the myelination of nerves in the CNS. It is speculated to serve as an adhesion molecule, providing structural integrity to the myelin sheath .

Expression Patterns: MOG is expressed late in the development of oligodendrocytes and is found on the outermost surface of myelin sheaths .

Tissue Distribution: MOG is uniquely expressed in oligodendrocyte membranes and myelin sheaths in the CNS . It is found in various regions of the brain, including the substantia nigra, hippocampus, putamen, and corpus callosum .

Biological Functions

Primary Biological Functions: MOG is thought to function as a cellular adhesive molecule, a regulator of oligodendrocyte microtubule stability, and a mediator of interactions between myelin and the immune system .

Role in Immune Responses: MOG is a potential target of cellular and humoral immune responses in inflammatory demyelinating diseases . It is involved in the regulation of immune responses and the T cell receptor signaling pathway .

Pathogen Recognition: MOG has been implicated as a receptor for various pathogens, including viruses .

Modes of Action

Mechanisms with Other Molecules and Cells: MOG interacts with other molecules and cells through its role as an adhesion molecule and its involvement in immune interactions .

Binding Partners: MOG binds to various immune molecules, including antibodies, which can lead to immune-mediated demyelination .

Downstream Signaling Cascades: MOG is involved in downstream signaling cascades that regulate immune responses and cell adhesion .

Regulatory Mechanisms

Transcriptional Regulation: The expression of MOG is regulated by various transcription factors, including Olig1, Olig2, Mash, Nkx2.2, and Sox10 .

Post-Translational Modifications: MOG undergoes post-translational modifications that are essential for its function and stability .

Applications

Biomedical Research: MOG is used as a model antigen in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS) .

Diagnostic Tools: MOG antibodies are used as biomarkers for diagnosing MOG antibody-associated disease (MOGAD), a distinct CNS demyelinating disease .

Therapeutic Strategies: Targeting MOG and its antibodies is being explored as a potential therapeutic strategy for treating demyelinating diseases .

Role in the Life Cycle

Development: MOG is expressed late in the development of oligodendrocytes and is essential for the maturation of these cells .

Aging and Disease: MOG plays a role in maintaining the integrity of the myelin sheath throughout life. Its dysfunction is associated with various demyelinating diseases, including multiple sclerosis and MOGAD .

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