Recombinant Proteins
Product List
TROVE2 Bovine
TROVE Domain Family, Member 2, Bovine
TROVE2 Bovine, Biotin
TROVE Domain Family Member 2 Human Recombinant, Biotinlyated
TROVE2, a biotinylated natural protein with a molecular weight of 58kDa, is derived from bovine tissues and purified using specialized protein-chemical techniques.
Bovine tissues.
TROVE2 His Human
TROVE Domain Family Member 2 His Tag Human Recombinant
TROVE2 Human
TROVE Domain Family Member 2 Human Recombinant
TROVE2 Human, His Biotin
TROVE Domain Family Member 2 Human Recombinant, His Tag Biotinylated
TROVE2 Human Recombinant Biotin is a single, non-glycosylated polypeptide chain with a molecular weight of 56kDa, produced in E. coli. It features a 6xHis tag at the N-terminus to facilitate purification, which is carried out using proprietary chromatographic methods.
Escherichia Coli.
Introduction
The TROVE domain family, named after Telomerase, Ro, and Vault, is a group of RNA-binding proteins that are components of ribonucleoprotein particles. These proteins are involved in various cellular processes, including RNA stabilization and protection from degradation . The TROVE domain is characterized by a doughnut-shaped structure consisting of seven helical HEAT-like repeats .
Key Biological Properties: TROVE domain proteins, such as TROVE2, are RNA-binding proteins that interact with misfolded non-coding RNAs, pre-5S rRNA, and small cytoplasmic RNA molecules known as Y RNAs . They may stabilize these RNAs and protect them from degradation.
Expression Patterns: TROVE2 exhibits low tissue specificity and is found in various cell types and tissues . It is predominantly located in the cytosol and nucleoplasm .
Tissue Distribution: TROVE2 is expressed in multiple tissues, including the brain, immune cells, and various cancer cell lines .
Primary Biological Functions: TROVE domain proteins play a crucial role in RNA stabilization and protection. They bind to misfolded non-coding RNAs and other RNA molecules, preventing their degradation .
Role in Immune Responses: TROVE2 is involved in the immune response by binding to endogenous Alu retroelements, which are induced by type I interferon and stimulate pro-inflammatory cytokine secretion .
Pathogen Recognition: TROVE2 may play a role in recognizing and responding to pathogens by interacting with RNA molecules and stimulating immune signaling pathways .
Mechanisms with Other Molecules and Cells: TROVE domain proteins interact with various RNA molecules and other proteins. For example, TROVE2 binds to Y RNAs and Alu retroelements .
Binding Partners: TROVE2 interacts with several RNA molecules, including misfolded non-coding RNAs, pre-5S rRNA, and Y RNAs .
Downstream Signaling Cascades: TROVE2 is involved in downstream signaling cascades that regulate the expression of inflammatory genes and other cellular responses .
Regulatory Mechanisms: The expression and activity of TROVE domain proteins are regulated at multiple levels, including transcriptional regulation and post-translational modifications .
Transcriptional Regulation: TROVE2 expression is regulated by various transcription factors and signaling pathways that respond to cellular stress and immune signals .
Post-Translational Modifications: TROVE2 undergoes post-translational modifications that may affect its stability, localization, and interactions with other molecules .
Biomedical Research: TROVE domain proteins are valuable tools in biomedical research for studying RNA biology, immune responses, and cellular stress mechanisms .
Diagnostic Tools: TROVE2 and other TROVE domain proteins can serve as biomarkers for autoimmune diseases, such as systemic lupus erythematosus (SLE), where they are recognized by autoantibodies .
Therapeutic Strategies: Targeting TROVE domain proteins and their interactions with RNA molecules may offer therapeutic potential for treating autoimmune diseases and other conditions involving RNA dysregulation .
Development: TROVE domain proteins play essential roles in cellular development by stabilizing and protecting RNA molecules during various stages of cell growth and differentiation .
Aging: The function of TROVE domain proteins may decline with age, leading to increased RNA degradation and cellular stress .
Disease: Dysregulation of TROVE domain proteins is associated with autoimmune diseases, such as SLE, where they are targeted by autoantibodies . They may also play roles in cancer and other diseases involving RNA dysregulation .
