Recombinant Proteins

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Product List

BATF Human

Basic Leucine Zipper Transcription Factor Human Recombinant

BATF Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 145 amino acids (1-125 a.a.) and having a molecular mass of 16.2kDa. The BATF is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25874
Source
Escherichia Coli.
Appearance
BATF is supplied as a sterile filtered colorless solution.

BATF3 Human

Basic Leucine Zipper Transcription Factor ATF-Like 3 Human Recombinant

BATF3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 150 amino acids (1-127 a.a) and having a molecular mass of 16.9kDa.
BATF3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25966
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.

Introduction

Definition and Classification

BATF (Basic Leucine Zipper ATF-Like Transcription Factor) is a member of the activator protein-1 (AP-1) family of transcription factors. It is characterized by its basic leucine zipper (bZIP) domain, which allows it to dimerize with other proteins such as JUN to regulate gene expression .

Biological Properties

Key Biological Properties: BATF is crucial for the differentiation and function of various immune cells, including T-helper (Th) cells and B cells . It lacks a transactivation domain, which means it requires dimerization with other proteins to exert its effects .

Expression Patterns: BATF is predominantly expressed in immune cells, particularly in T and B lymphocytes . Its expression is regulated by developmental transitions and environmental cues .

Tissue Distribution: BATF is primarily found in lymphoid tissues, such as the spleen and lymph nodes, where it plays a critical role in immune responses .

Biological Functions

Primary Biological Functions: BATF is essential for the differentiation of Th17 cells, follicular helper T (Tfh) cells, and regulatory T (Treg) cells . It regulates the expression of key transcription factors and cytokines involved in immune responses .

Role in Immune Responses: BATF is involved in the regulation of immune responses by controlling the differentiation and function of various T cell subsets . It plays a role in pathogen recognition and the development of effective immune responses .

Modes of Action

Mechanisms with Other Molecules and Cells: BATF forms heterodimers with JUN proteins to bind to AP-1 sites on DNA and regulate gene transcription . It interacts with other transcription factors, such as IRF4, to modulate the expression of target genes .

Binding Partners: BATF primarily dimerizes with JUN proteins, but it can also interact with other bZIP proteins .

Downstream Signaling Cascades: BATF regulates the expression of genes involved in T cell differentiation and function, including those encoding cytokines and transcription factors .

Regulatory Mechanisms

Transcriptional Regulation: BATF expression is regulated by various transcription factors and signaling pathways, including those activated by T cell receptor (TCR) signaling .

Post-Translational Modifications: BATF activity can be modulated by post-translational modifications, such as phosphorylation, which affect its ability to bind DNA and interact with other proteins .

Applications

Biomedical Research: BATF is a valuable target in immunology research due to its role in T cell differentiation and function . It is studied in the context of autoimmune diseases, cancer, and infectious diseases .

Diagnostic Tools: Antibodies against BATF are used in various diagnostic applications, including Western blotting, immunohistochemistry, and flow cytometry .

Therapeutic Strategies: Modulating BATF activity has potential therapeutic applications in treating autoimmune diseases, cancer, and other conditions involving dysregulated immune responses .

Role in the Life Cycle

Development: BATF is crucial for the development of functional T and B cells, which are essential for adaptive immunity .

Aging and Disease: Dysregulation of BATF expression or function can lead to immune-related diseases, such as autoimmune disorders and cancer . Understanding BATF’s role in these processes can inform the development of new therapeutic strategies .

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