Recombinant Proteins

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BATF Human

Basic Leucine Zipper Transcription Factor Human Recombinant

Recombinant human BATF, expressed in E. coli, is a single, non-glycosylated polypeptide chain containing 145 amino acids (1-125 a.a.) with an N-terminal 20 amino acid His tag. This protein, with a molecular mass of 16.2 kDa, is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25874
Source
Escherichia Coli.
Appearance
BATF is provided as a sterile, colorless, and filtered solution.

BATF3 Human

Basic Leucine Zipper Transcription Factor ATF-Like 3 Human Recombinant

Recombinant BATF3, derived from humans and produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 150 amino acids (specifically, amino acids 1 to 127) and has a molecular weight of 16.9 kDa. This protein is fused to a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25966
Source
Escherichia Coli.
Appearance
Clear, colorless solution that has been sterilized through filtration.
Definition and Classification

BATF (Basic Leucine Zipper ATF-Like Transcription Factor) is a member of the activator protein-1 (AP-1) family of transcription factors. It is characterized by its basic leucine zipper (bZIP) domain, which allows it to dimerize with other proteins such as JUN to regulate gene expression .

Biological Properties

Key Biological Properties: BATF is crucial for the differentiation and function of various immune cells, including T-helper (Th) cells and B cells . It lacks a transactivation domain, which means it requires dimerization with other proteins to exert its effects .

Expression Patterns: BATF is predominantly expressed in immune cells, particularly in T and B lymphocytes . Its expression is regulated by developmental transitions and environmental cues .

Tissue Distribution: BATF is primarily found in lymphoid tissues, such as the spleen and lymph nodes, where it plays a critical role in immune responses .

Biological Functions

Primary Biological Functions: BATF is essential for the differentiation of Th17 cells, follicular helper T (Tfh) cells, and regulatory T (Treg) cells . It regulates the expression of key transcription factors and cytokines involved in immune responses .

Role in Immune Responses: BATF is involved in the regulation of immune responses by controlling the differentiation and function of various T cell subsets . It plays a role in pathogen recognition and the development of effective immune responses .

Modes of Action

Mechanisms with Other Molecules and Cells: BATF forms heterodimers with JUN proteins to bind to AP-1 sites on DNA and regulate gene transcription . It interacts with other transcription factors, such as IRF4, to modulate the expression of target genes .

Binding Partners: BATF primarily dimerizes with JUN proteins, but it can also interact with other bZIP proteins .

Downstream Signaling Cascades: BATF regulates the expression of genes involved in T cell differentiation and function, including those encoding cytokines and transcription factors .

Regulatory Mechanisms

Transcriptional Regulation: BATF expression is regulated by various transcription factors and signaling pathways, including those activated by T cell receptor (TCR) signaling .

Post-Translational Modifications: BATF activity can be modulated by post-translational modifications, such as phosphorylation, which affect its ability to bind DNA and interact with other proteins .

Applications

Biomedical Research: BATF is a valuable target in immunology research due to its role in T cell differentiation and function . It is studied in the context of autoimmune diseases, cancer, and infectious diseases .

Diagnostic Tools: Antibodies against BATF are used in various diagnostic applications, including Western blotting, immunohistochemistry, and flow cytometry .

Therapeutic Strategies: Modulating BATF activity has potential therapeutic applications in treating autoimmune diseases, cancer, and other conditions involving dysregulated immune responses .

Role in the Life Cycle

Development: BATF is crucial for the development of functional T and B cells, which are essential for adaptive immunity .

Aging and Disease: Dysregulation of BATF expression or function can lead to immune-related diseases, such as autoimmune disorders and cancer . Understanding BATF’s role in these processes can inform the development of new therapeutic strategies .

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