Recombinant Proteins
Product List
REN Human
Renin Human Recombinant
REN Human, HEK
Renin Human Recombinant, HEK
REN Human, sf9
Renin Human Recombinant, sf9
REN Mouse
Renin Mouse Recombinant
Introduction
Renin, also known as angiotensinogenase, is an aspartic protease enzyme secreted by the kidneys. It plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure, fluid, and electrolyte balance . Renin is classified as an enzyme with the EC number 3.4.23.15 .
Key Biological Properties: Renin is an enzyme that catalyzes the conversion of angiotensinogen to angiotensin I, a precursor to angiotensin II, which is a potent vasoconstrictor .
Expression Patterns: Renin is primarily expressed in the juxtaglomerular cells of the kidneys . It is also found in other tissues, including the placenta .
Tissue Distribution: Renin is predominantly distributed in the kidneys but can also be detected in the plasma, liver, and other tissues .
Primary Biological Functions: The main function of renin is to regulate blood pressure and fluid balance through the RAAS . It converts angiotensinogen to angiotensin I, which is then converted to angiotensin II, leading to vasoconstriction and increased blood pressure .
Role in Immune Responses and Pathogen Recognition: While renin’s primary role is in blood pressure regulation, it also has implications in immune responses and inflammation .
Mechanisms with Other Molecules and Cells: Renin acts by cleaving angiotensinogen, produced by the liver, to form angiotensin I . Angiotensin I is then converted to angiotensin II by angiotensin-converting enzyme (ACE), primarily in the lungs .
Binding Partners and Downstream Signaling Cascades: Angiotensin II binds to AT1 and AT2 receptors, leading to various physiological effects, including vasoconstriction, aldosterone release, and increased sodium reabsorption .
Regulatory Mechanisms: Renin release is regulated by several factors, including blood pressure, sodium levels, and sympathetic nervous system activity . It is inhibited by atrial natriuretic peptide (ANP) and stimulated by prostaglandins and nitric oxide .
Transcriptional Regulation and Post-Translational Modifications: Renin gene expression is regulated at the transcriptional level by various factors, including cAMP and calcium . Post-translational modifications, such as glycosylation, also play a role in renin’s activity .
Biomedical Research: Renin is a key target in hypertension research. Transgenic mice models have been used to study the effects of renin on blood pressure regulation .
Diagnostic Tools: Renin levels are measured to diagnose and manage conditions like hypertension and heart failure .
Therapeutic Strategies: Renin inhibitors, ACE inhibitors, and angiotensin receptor blockers (ARBs) are used to treat hypertension and related cardiovascular diseases .
