Recombinant Proteins
Product List
MFAP2 Human
Microfibrillar-associated Protein 2 Human Recombinant
MFAP3 Human
Microfibrillar-associated Protein 3 Human Recombinant
MFAP4 Human
Microfibrillar-associated Protein 4 Human Recombinant
MFAP4 Human, Sf9
Microfibrillar-associated Protein 4 Human Recombinant, Sf9
Introduction
Key Biological Properties: MFAPs are integral components of elastic fibers and microfibrils, contributing to the structural integrity of tissues . They interact with other extracellular matrix proteins such as fibrillin and tropoelastin .
Expression Patterns and Tissue Distribution: MFAPs are highly expressed in elastin-rich tissues such as the lungs, blood vessels, and skin . MFAP4, for instance, is found in elastic fibers and interacts directly with fibrillin-1 .
Primary Biological Functions: MFAPs play a crucial role in the organization of the extracellular matrix (ECM), aiding in the proper assembly of elastic fibers . They are also involved in cell adhesion and intercellular interactions .
Role in Immune Responses and Pathogen Recognition: MFAP4 has been identified as a macrophage-specific innate immune molecule in teleost fish, indicating its role in host defense .
Mechanisms with Other Molecules and Cells: MFAPs bind to various ECM components, including tropoelastin and fibrillin-1 and -2 . They also interact with integrin receptors, influencing cell signaling pathways .
Binding Partners and Downstream Signaling Cascades: MFAP4 binds to tropoelastin and fibrillin, promoting elastic fiber assembly . It also interacts with RGD-dependent integrin receptors, contributing to disease development and progression .
Transcriptional Regulation: The expression of MFAP genes can be regulated by various factors. For example, the promoter of the human MFAP4 gene is a TATA-less promoter that can be up-regulated by retinol and coenzyme Q10 .
Post-Translational Modifications: MFAPs undergo various post-translational modifications that influence their function and interactions with other ECM components .
Biomedical Research: MFAPs are studied for their role in tissue engineering and regenerative medicine due to their involvement in ECM organization and elastic fiber formation .
Diagnostic Tools: Elevated levels of MFAPs, such as MFAP5, have been associated with certain cancers, making them potential biomarkers for disease diagnosis .
Therapeutic Strategies: Targeting MFAPs could offer therapeutic benefits in treating fibrotic diseases and improving wound healing outcomes .
