Recombinant Proteins
Product List
THAP1 Human
THAP Domain Containing, Apoptosis Associated Protein 1 Human Recombinant
THAP11 Human
THAP Domain Containing, Apoptosis Associated Protein 11 Human Recombinant
THAP3 Human
THAP Domain Containing, Apoptosis Associated Protein 3 Human Recombinant
THAP7 Human
THAP Domain Containing, Apoptosis Associated Protein 7 Human Recombinant
Introduction
The THAP (Thanatos-associated protein) domain is a conserved DNA-binding domain characterized by a zinc-coordinating C2CH motif. It is found in a family of proteins known as THAP proteins, which are involved in various cellular processes such as transcriptional regulation, apoptosis, and cell cycle control . The human THAP protein family consists of twelve members (THAP0-THAP11), each varying in size and function .
Key Biological Properties: The THAP domain is primarily involved in DNA binding and transcriptional regulation. It binds DNA via a zinc-coordinating C2CH motif, which is essential for its function .
Expression Patterns and Tissue Distribution: THAP proteins are expressed in various tissues, with some members showing tissue-specific expression. For example, THAP1 is highly expressed in the brain, while THAP5 is predominantly found in the heart .
Primary Biological Functions: THAP proteins play crucial roles in regulating gene expression, cell proliferation, apoptosis, and maintaining pluripotency in stem cells .
Role in Immune Responses and Pathogen Recognition: Some THAP proteins are involved in immune responses. For instance, THAP0 is a member of the apoptotic cascade induced by IFN-γ, which is part of the immune response .
Mechanisms with Other Molecules and Cells: THAP proteins interact with various molecules and cellular components to exert their functions. For example, THAP1 interacts with RRM1 to regulate cell proliferation .
Binding Partners and Downstream Signaling Cascades: THAP proteins bind to specific DNA sequences and recruit other proteins to form complexes that regulate gene expression. For instance, THAP7 binds to hypo-acetylated histone H4 tails, playing a role in transcriptional repression .
Transcriptional Regulation: THAP proteins act as transcription factors, binding to specific DNA sequences to regulate the expression of target genes .
Post-Translational Modifications: THAP proteins undergo various post-translational modifications, such as phosphorylation and ubiquitination, which regulate their activity and stability .
Biomedical Research: THAP proteins are studied for their roles in various diseases, including cancer, heart disease, and neurological disorders .
Diagnostic Tools and Therapeutic Strategies: THAP proteins have potential as biomarkers for disease diagnosis and as targets for therapeutic interventions. For example, THAP11 has been studied for its role in colon cancer .
Development to Aging and Disease: THAP proteins are involved in various stages of the life cycle, from development to aging. They play roles in cell proliferation, apoptosis, and maintaining stem cell pluripotency . Dysregulation of THAP proteins can lead to diseases such as cancer and neurological disorders .
