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Monoclonal Antibodies

Other Monoclonal Antibodies

Anti Human Lymphocyte

Anti Mouse Cytokine

Anti Human Cytokine

Anti Mouse Lymphocyte

Anti-GST Monoclonal

Anti Viral Monoclonal

Anti Human Heat Shock Protein

Anti Human Enzyme

Product List

IgG Antibody

IgG, Mouse Anti Human

This monoclonal anti-human IgG antibody is specifically designed for use in lateral flow immunoassays, particularly for rapid dengue testing.

Shipped with Ice Packs

Cat. No.

BT20934

Appearance

A sterile, filtered solution that is clear and colorless.

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IgG-Fc antibody

IgG-Fc, Mouse Anti-Human

Shipped with Ice Packs

Cat. No.

BT20997

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EIF5A Antibody

Eukaryotic Translation Initiation Factor 5A, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT16721

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EPCAM Antibody

Epithelial Cell Adhesion Molecule, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT16803

Appearance

Sterile filtered colorless solution.

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IgM Antibody

IgM, Mouse Anti Human

This is a monoclonal anti-human IgM antibody specifically designed for use in lateral flow immunoassays, particularly for dengue IgG/IgM tests.

Shipped with Ice Packs

Cat. No.

BT21067

Appearance

Sterile Filtered clear colorless solution.

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IMP3 Antibody

IMP3, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT21129

Appearance

Colorless, sterile-filtered solution.

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ING2 Antibody

Inhibitor of Growth Family Member 2, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT21193

Appearance

Clear, colorless solution that is sterile and filtered.

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Insulin Antibody

Insulin, Mouse Anti-Human

These antibody-producing cells (clones) were created by fusing myeloma cells (X63-Ag8-653) with spleen cells extracted from Balb/c mice. These mice had been immunized with purified human insulin to trigger an immune response.

Shipped with Ice Packs

Cat. No.

BT21268

Appearance

Clear, sterile solution.

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ISG15 Antibody

Interferon stimulated gene 15, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT21365

Appearance

A clear, colorless solution that is sterile-filtered.

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ITGB1 Antibody

Mouse Anti Human Integrin Beta 1

Shipped with Ice Packs

Cat. No.

BT21427

Appearance

A clear, colorless solution that has been sterilized by filtration.

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Introduction

Definition and Classification

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are produced by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can be classified based on their source and structure:

Murine mAbs: Derived from mouse cells.
Chimeric mAbs: Contain both human and mouse components.
Humanized mAbs: Mostly human, with only small mouse-derived components.
Human mAbs: Fully human antibodies.

Biological Properties

Monoclonal antibodies exhibit several key biological properties:

Protein Sequence: Identical protein sequences and antigen-binding sites.
Expression Patterns: Produced by B lymphocytes and expressed in hybridoma cells.
Tissue Distribution: Can be designed to target specific tissues or cells, such as cancer cells.

Biological Functions

Monoclonal antibodies play crucial roles in the immune system:

Pathogen Recognition: Bind to specific antigens on pathogens, marking them for destruction.
Immune Response: Enhance the immune system’s ability to fight infections and diseases.
Therapeutic Functions: Used in treating various diseases, including cancer, autoimmune disorders, and infectious diseases.

Modes of Action

Monoclonal antibodies interact with other molecules and cells through various mechanisms:

Binding Partners: Bind to specific antigens on target cells.
Downstream Signaling Cascades: Trigger immune responses by activating immune cells and complement systems.
Effector Functions: Engage Fc receptors on immune cells, leading to cell-mediated cytotoxicity.

Regulatory Mechanisms

The expression and activity of monoclonal antibodies are tightly regulated:

Transcriptional Regulation: Controlled by specific transcription factors that regulate the expression of antibody genes.
Post-Translational Modifications: Undergo modifications such as glycosylation, which can affect their stability and function.

Applications

Monoclonal antibodies have a wide range of applications in biomedical research and medicine:

Diagnostic Tools: Used in assays to detect specific antigens in samples.
Therapeutic Strategies: Employed in the treatment of cancers, autoimmune diseases, and infectious diseases.
Biomedical Research: Serve as tools to study cellular processes and disease mechanisms.

Role in the Life Cycle

Monoclonal antibodies play roles throughout the life cycle:

Development: Used in prenatal diagnostics and treatments.
Aging: Help manage age-related diseases such as cancer and Alzheimer’s.
Disease: Provide targeted therapies for various diseases, improving patient outcomes.