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Monoclonal Antibodies

Other Monoclonal Antibodies

Anti Human Lymphocyte

Anti Mouse Cytokine

Anti Human Cytokine

Anti Mouse Lymphocyte

Anti-GST Monoclonal

Anti Viral Monoclonal

Anti Human Heat Shock Protein

Anti Human Enzyme

Product List

JAM2 antibody

Mouse Anti Human Junctional Adhesion Molecule 2

Shipped with Ice Packs

Cat. No.

BT21538

Appearance

The solution is sterile-filtered and colorless.

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KCTD15 Antibody

Potassium channel tetramerisation domain containing 15, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT21618

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KCTD15 PAT2B11AT Antibody

Potassium channel tetramerisation domain containing 15, Clone PAT2B11AT, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT21714

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KIR2DL1 Antibody

Killer Cell Immunoglobulin-Like Receptor 2 Domains Long Cytoplasmic Tail 1, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT21802

Appearance

A clear and colorless solution that has been sterilized by filtration.

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KIR2DL3 Antibody

Killer Cell Immunoglobulin-Like Receptor 2 Domains Long Cytoplasmic Tail 3, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT21865

Appearance

A clear and colorless solution that has been sterilized by filtration.

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KIR2DS4 Antibody

Killer Cell Immunoglobulin-Like Receptor 2 Domains Short Cytoplasmic Tail 4, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT21963

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KLF4 Antibody

Krueppel-like factor 4, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT22054

Appearance

Clear, sterile-filtered solution.

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KLF7 Antibody

Krueppel-like factor 7, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT22153

Appearance

The product is a sterile, colorless solution.

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KLRD1 Antibody

Mouse Anti Human Killer Cell Lectin Like Receptor D1

Shipped with Ice Packs

Cat. No.

BT22235

Appearance

A clear and colorless liquid that has been sterilized by filtration.

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KRT14 Antibody

Cytokeratin 14, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT22801

Appearance

Clear, colorless solution that has been sterilized by filtration.

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Showing 161 to 170 of 619 results

Introduction

Definition and Classification

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are produced by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can be classified based on their source and structure:

Murine mAbs: Derived from mouse cells.
Chimeric mAbs: Contain both human and mouse components.
Humanized mAbs: Mostly human, with only small mouse-derived components.
Human mAbs: Fully human antibodies.

Biological Properties

Monoclonal antibodies exhibit several key biological properties:

Protein Sequence: Identical protein sequences and antigen-binding sites.
Expression Patterns: Produced by B lymphocytes and expressed in hybridoma cells.
Tissue Distribution: Can be designed to target specific tissues or cells, such as cancer cells.

Biological Functions

Monoclonal antibodies play crucial roles in the immune system:

Pathogen Recognition: Bind to specific antigens on pathogens, marking them for destruction.
Immune Response: Enhance the immune system’s ability to fight infections and diseases.
Therapeutic Functions: Used in treating various diseases, including cancer, autoimmune disorders, and infectious diseases.

Modes of Action

Monoclonal antibodies interact with other molecules and cells through various mechanisms:

Binding Partners: Bind to specific antigens on target cells.
Downstream Signaling Cascades: Trigger immune responses by activating immune cells and complement systems.
Effector Functions: Engage Fc receptors on immune cells, leading to cell-mediated cytotoxicity.

Regulatory Mechanisms

The expression and activity of monoclonal antibodies are tightly regulated:

Transcriptional Regulation: Controlled by specific transcription factors that regulate the expression of antibody genes.
Post-Translational Modifications: Undergo modifications such as glycosylation, which can affect their stability and function.

Applications

Monoclonal antibodies have a wide range of applications in biomedical research and medicine:

Diagnostic Tools: Used in assays to detect specific antigens in samples.
Therapeutic Strategies: Employed in the treatment of cancers, autoimmune diseases, and infectious diseases.
Biomedical Research: Serve as tools to study cellular processes and disease mechanisms.

Role in the Life Cycle

Monoclonal antibodies play roles throughout the life cycle:

Development: Used in prenatal diagnostics and treatments.
Aging: Help manage age-related diseases such as cancer and Alzheimer’s.
Disease: Provide targeted therapies for various diseases, improving patient outcomes.