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Neurotrophins

Beta-NGF

CDNF

CNTF

GDNF

Glia Maturation Factor

MANF

Midkine

Neuregulin

Neuroglobin

Neuritin

Neuropilin

Neurotrophic factors

Persephin

Pigment Epithelium-Derived Factor

Pleiotrophin

Other Neurotrophins

Product List

Beta NGF Mouse

Beta Nerve Growth Factor Mouse Recombinant

Recombinant Mouse b-NGF, expressed in E. coli, is a non-glycosylated homodimer linked by disulfide bonds. Each polypeptide chain consists of 120 amino acids, resulting in a molecular mass of 13,471 Daltons per chain. The purification of Recombinant Mouse-beta-NGF is achieved through advanced biological purification techniques.

Shipped with Ice Packs

Cat. No.

BT6970

Source

Escherichia Coli.

Appearance

White, lyophilized (freeze-dried) powder, sterile filtered.

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bNGF Human, CHO

Beta-Nerve Growth Factor Human Recombinant, CHO

Recombinant human Nerve Growth Factor-beta, produced in Chinese Hamster Ovary (CHO) cells, is a protein composed of two identical chains, each consisting of 118 amino acids. The protein exists as a homodimer, meaning two identical copies of the protein are linked together. It undergoes glycosylation, a process of adding sugar molecules, and has a molecular weight of 26.5 kDa. This NGF-β is purified using specialized chromatographic techniques to ensure its high quality.

Shipped with Ice Packs

Cat. No.

BT7055

Source

Chinese Hamster Ovary Cells.

Appearance

This product appears as a sterile, white powder that has been freeze-dried.

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NGFR Human

Nerve Growth Factor Receptor Human Recombinant

NGFR, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain. It consists of 230 amino acids (29-250 a.a.) and has a molecular mass of 24.6kDa. On SDS-PAGE under reducing conditions, it migrates at 40-57kDa. An 8 amino acid His tag is present at the C-Terminus of the expressed NGFR. Purification is carried out using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7112

Source

Sf9, Baculovirus cells.

Appearance

A clear, colorless solution that has been sterilized by filtration.

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ProNGF Human

Pro-Nerve Growth Factor Human Recombinant

Recombinant Human Pro-NGF, expressed in E. coli, is a non-glycosylated polypeptide chain comprising 224 amino acids. It exhibits a molecular weight of 25 kDa. The purification process involves proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7161

Source

Escherichia Coli.

Appearance

Sterile Filtered White lyophilized powder.

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b NGF Human

Beta Nerve Growth Factor Human Recombinant

Recombinant Human Nerve Growth Factor-beta, produced in E. coli, is a non-glycosylated homodimer formed by two identical polypeptide chains. Each chain contains 121 amino acids and has a molecular weight of 13.6 kDa, resulting in a total molecular weight of 27.2 kDa for the dimer. The two chains are linked by a disulfide bond. The purification process of NGF-b involves proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT6660

Source

Escherichia Coli.

Appearance

White, lyophilized (freeze-dried) powder, sterile-filtered.

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b NGF Human, HEK

beta Nerve Growth Factor Human Recombinant, HEK

Recombinant human BNGF, produced in HEK293 cells, is a homodimeric protein consisting of two identical polypeptide chains linked by a disulfide bond. Each chain contains 118 amino acids (Ser122-Arg239) and has a molecular weight of 26.5 kDa. The protein is glycosylated, meaning it has sugar molecules attached.

Shipped with Ice Packs

Cat. No.

BT6772

Source

HEK293 cells.

Appearance

White powder, sterile-filtered and lyophilized.

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b NGF Mouse

Beta-Nerve Growth Factor Mouse

NGF beta Mouse, derived from the submaxillary gland of adult mice, is a non-glycosylated homodimeric polypeptide. It comprises two identical chains, each containing 120 amino acids, with a molecular weight of 13,471 Daltons per chain. This protein undergoes purification using advanced biological techniques.

Shipped with Ice Packs

Cat. No.

BT6845

Source

Submaxillary Gland of Grown Mouse.

Appearance

White, sterile-filtered powder obtained through lyophilization (freeze-drying).

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Introduction

Definition and Classification

Beta-Nerve Growth Factor (Beta-NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is a member of the neurotrophin family, which also includes Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4). Beta-NGF is the biologically active component of the 7S NGF complex, which also includes Alpha-NGF and Gamma-NGF.

Biological Properties

Key Biological Properties: Beta-NGF is crucial for the development and survival of nerve cells (neurons), especially those that transmit pain, temperature, and touch sensations. It functions by attaching to its receptors, initiating signaling pathways inside the cell.

Expression Patterns: Beta-NGF is expressed in various tissues, including the central and peripheral nervous systems, as well as non-neuronal tissues such as the immune system.

Tissue Distribution: It is produced by every peripheral tissue/organ innervated by sensory afferents and/or sympathetic efferents, as well as by central and peripheral nervous system and immune cells.

Biological Functions

Primary Biological Functions: Beta-NGF promotes the growth, differentiation, and survival of neurons. It is essential for the maintenance of sympathetic and sensory neurons and plays a critical role in the survival of pancreatic beta cells.

Role in Immune Responses: Beta-NGF acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival.

Pathogen Recognition: Beta-NGF is involved in the regulation of the immune system, influencing both innate and adaptive immune responses.

Modes of Action

Mechanisms with Other Molecules and Cells: Beta-NGF binds to its high-affinity receptor, Tropomyosin receptor kinase A (TrkA), and low-affinity receptor, p75 neurotrophin receptor (p75NTR). This binding initiates various signaling pathways, including the PI 3-kinase, ras, and PLC pathways.

Binding Partners: The primary binding partners of Beta-NGF are TrkA and p75NTR receptors.

Downstream Signaling Cascades: Upon binding to TrkA, Beta-NGF drives the homodimerization of the receptor, leading to the autophosphorylation of the tyrosine kinase segment and activation of downstream signaling pathways.

Regulatory Mechanisms

Expression and Activity Control: The expression of Beta-NGF is regulated by various factors, including inflammatory cytokines and stress. Its activity is modulated through binding to its receptors and subsequent activation of signaling pathways.

Transcriptional Regulation: The transcription of the NGF gene is influenced by various transcription factors and signaling molecules.

Post-Translational Modifications: Beta-NGF undergoes proteolytic cleavage from its precursor form, proNGF, to become biologically active.

Applications

Biomedical Research: Beta-NGF is widely used in research to study neuronal growth, differentiation, and survival. It is also used to investigate the mechanisms of neurodegenerative diseases and potential therapeutic strategies.

Diagnostic Tools: Beta-NGF levels are measured in various diagnostic assays to assess nerve damage and neurodegenerative conditions.

Therapeutic Strategies: Beta-NGF has potential therapeutic applications in treating neurodegenerative diseases, peripheral neuropathies, and certain immune disorders.

Role in the Life Cycle

Development: Beta-NGF is essential for the development of the nervous system, promoting the growth and differentiation of neurons during embryonic development.

Aging: In adulthood, Beta-NGF maintains the function and survival of neurons, playing a role in cognitive function and memory.

Disease: Beta-NGF is involved in the pathophysiology of various diseases, including neurodegenerative disorders, diabetes, and cancer. It has both neuroprotective and pro-apoptotic roles depending on the context.