Product List

CNTF Human

Ciliary-Neurotrophic Factor Human Recombinant

Ciliary Neurotrophic Factor Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids and having a molecular mass of 22706 Dalton.
The CNTF is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7502
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

CNTF Human, His

Ciliary Neurotrophic Factor Human Recombinant, His Tag

Ciliary Neurotrophic Factor Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain (aa 1-200) containing a total of 220 amino acids and having a molecular mass of 25kDa. The CNTF protein is fused to a 20 aa His Tag at N-terminus and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7583
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless clear solution.

CNTF Human, His Active

Ciliary Neurotrophic Factor Human Recombinant, His Tag Active

CNTF Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-200 a.a) and having a molecular mass of 25kDa.
CNTF is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7633
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

CNTF Mouse

Ciliary-Neurotrophic Factor Mouse Recombinant

Ciliary Neurotrophic Factor Recombinant Mouse produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids and having a molecular mass of 22.6kDa.
The CNTF is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7702
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

CNTF Rat

Ciliary Neurotrophic Factor Rat Recombinant

CNTF Recombinant Rat produced in E.Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 22834 Dalton.
The CNTF is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7901
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

CNTF Rat, His

Ciliary Neurotrophic Factor Rat Recombinant, His Tag

CNTF Rat Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 223 amino acids (1-200a.a) and having a molecular mass of 25.2kDa.
CNTF is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT7964
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.

CNTFR Human

Ciliary Neurotrophic Factor Receptor Human Recombinant

CNTFR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 341 amino acids (23-342 a.a) and having a molecular mass of 38.1kDa.
CNTFR is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8043
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless clear solution.

CNTFR Rat

Ciliary Neurotrophic Factor Receptor Rat Recombinant

CNTFR Rat Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 328 amino acids (23-342a.a) and having a molecular mass of 36.9kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
CNTFR is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8109
Source
Sf9, Baculovirus cells.
Appearance
Sterile Filtered colorless clear solution.

CTNFR Human, Sf9

Ciliary Neurotrophic Factor Receptor Human Recombinant, Sf9

CTNFR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 329 amino acids (23-342a.a.) and having a molecular mass of 36.9kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
CTNFR is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT8175
Source

Sf9, Baculovirus cells.

Appearance
Sterile Filtered colorless clear solution.

Introduction

Definition and Classification

Ciliary neurotrophic factor (CNTF) is a polypeptide hormone and neurotrophic factor primarily studied in the nervous system. It belongs to the neurokine family of cytokines, which includes other members such as leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and cardiotrophin-1 (CT-1) .

Biological Properties

Key Biological Properties: CNTF is a potent survival factor for neurons and oligodendrocytes. It promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations, including astrocytes .

Expression Patterns: CNTF is expressed in various tissues, including the hypothalamus, testicles, tibial nerve, sural nerve, gastrocnemius muscle, substantia nigra, and bone marrow .

Tissue Distribution: The expression of CNTF is prominent in the nervous system, particularly in the hypothalamus, where it plays a crucial role in neuronal survival and function .

Biological Functions

Primary Biological Functions: CNTF supports the survival and differentiation of various neuronal populations. It is involved in promoting the survival of motor neurons, sensory neurons, and astrocytes .

Role in Immune Responses and Pathogen Recognition: While CNTF’s primary functions are in the nervous system, it also has roles in immune responses, particularly in reducing tissue destruction during inflammatory attacks .

Modes of Action

Mechanisms with Other Molecules and Cells: CNTF exerts its effects by binding to a receptor complex consisting of CNTFRα (CNTF receptor alpha), LIFRβ (leukemia inhibitory factor receptor beta), and gp130 (glycoprotein 130) .

Binding Partners: The binding of CNTF to its receptor complex triggers the activation of intracellular signaling pathways, including the JAK/STAT pathway, which is crucial for neuronal survival and differentiation .

Downstream Signaling Cascades: Upon binding to its receptor, CNTF activates the JAK/STAT, MAPK/ERK, and PI3K/Akt pathways, which regulate various cellular mechanisms such as metabolism, apoptosis inhibition, and cytoskeletal dynamics .

Regulatory Mechanisms

Transcriptional Regulation: The expression of CNTF is regulated at the transcriptional level by various factors, including stress stimuli and injury responses .

Post-Translational Modifications: CNTF undergoes post-translational modifications that influence its stability and activity. These modifications include phosphorylation and glycosylation, which are essential for its proper function .

Applications

Biomedical Research: CNTF is widely used in research to study neuronal survival, differentiation, and neuroprotection .

Diagnostic Tools: CNTF levels in biological materials, such as blood and tears, are being investigated as potential biomarkers for neurodegenerative and brain diseases .

Therapeutic Strategies: CNTF and its agonists have shown promise in treating neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), as well as retinal degenerative diseases .

Role in the Life Cycle

Development: CNTF plays a critical role in the development of the nervous system by promoting the survival and differentiation of neurons and glial cells .

Aging and Disease: CNTF continues to be important throughout life, contributing to neuronal maintenance and repair. It has potential therapeutic applications in age-related neurodegenerative diseases and conditions involving neuronal damage .

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