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Neurotrophins

CNTF

Beta-NGF

CDNF

GDNF

Glia Maturation Factor

MANF

Midkine

Neuregulin

Neuroglobin

Neuritin

Neuropilin

Neurotrophic factors

Persephin

Pigment Epithelium-Derived Factor

Pleiotrophin

Other Neurotrophins

Product List

CNTFR Rat

Ciliary Neurotrophic Factor Receptor Rat Recombinant

Recombinant Rat CNTFR, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain containing 328 amino acids (23-342a.a). It has a molecular mass of 36.9kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). CNTFR is fused to an 8 amino acid His-tag at the C-terminus and purified by proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT8109

Source

Sf9, Baculovirus cells.

Appearance

A clear, colorless, and sterile filtered solution.

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CTNFR Human, Sf9

Ciliary Neurotrophic Factor Receptor Human Recombinant, Sf9

Produced in Sf9 Baculovirus cells, CTNFR is a single, glycosylated polypeptide chain consisting of 329 amino acids (23-342a.a.) with a molecular mass of 36.9kDa. Note that the molecular size on SDS-PAGE analysis will appear approximately between 40-57kDa. CTNFR is expressed with a 9 amino acid His tag at the C-terminus and undergoes purification using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT8175

Source

Sf9, Baculovirus cells.

Appearance

The product is a sterile-filtered solution that is colorless and clear.

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CNTF Mouse

Ciliary-Neurotrophic Factor Mouse Recombinant

Recombinant Mouse Ciliary Neurotrophic Factor, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 198 amino acids. It has a molecular mass of 22.6 kDa. The CNTF undergoes purification using proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT7702

Source

Escherichia Coli.

Appearance

Sterile Filtered White lyophilized powder.

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CNTF Rat

Ciliary Neurotrophic Factor Rat Recombinant

Recombinant Rat CNTF, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 200 amino acids. It has a molecular weight of 22.834 kDa. The purification of CNTF is achieved using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7901

Source

Escherichia Coli.

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

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CNTF Rat, His

Ciliary Neurotrophic Factor Rat Recombinant, His Tag

Recombinant CNTF Rat, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 223 amino acids (1-200a.a) with a molecular mass of 25.2kDa. It includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7964

Source

Escherichia Coli.

Appearance

The product appears as a clear, colorless solution free from particulate matter.

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CNTF Human

Ciliary-Neurotrophic Factor Human Recombinant

Recombinant Human Ciliary Neurotrophic Factor, produced in E. coli, is a single-chain polypeptide hormone with 199 amino acids. This non-glycosylated protein has a molecular weight of 22.7 kDa. Its purity is achieved using specialized chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7502

Source

Escherichia Coli.

Appearance

White, freeze-dried powder that has been sterilized by filtration.

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CNTF Human, His

Ciliary Neurotrophic Factor Human Recombinant, His Tag

Recombinant Human Ciliary Neurotrophic Factor, produced in E. coli, is a single, non-glycosylated polypeptide chain encompassing amino acids 1-200. With a molecular weight of 25 kDa, it includes a 20 amino acid His tag attached to the N-terminus. The protein is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT7583

Source

Escherichia Coli.

Appearance

A clear, colorless solution that has been sterilized by filtration.

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CNTF Human, His Active

Ciliary Neurotrophic Factor Human Recombinant, His Tag Active

Recombinant human CNTF, produced in E. coli, is a non-glycosylated polypeptide chain consisting of 220 amino acids (with a sequence spanning from amino acid position 1 to 200) and possessing a molecular weight of 25 kDa. For purification purposes, a 20 amino acid His-tag is fused to the N-terminus of CNTF, and proprietary chromatographic techniques are employed.

Shipped with Ice Packs

Cat. No.

BT7633

Source

Escherichia Coli.

Appearance

A clear solution that has been sterilized by filtration.

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CNTFR Human

Ciliary Neurotrophic Factor Receptor Human Recombinant

Recombinant human CNTFR, expressed in E. coli, is a single, non-glycosylated polypeptide chain containing 341 amino acids (residues 23-342). It has a molecular weight of 38.1 kDa. The protein is fused to a 21 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT8043

Source

Escherichia Coli.

Appearance

A clear, colorless, and sterile-filtered solution.

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Introduction

Definition and Classification

Ciliary neurotrophic factor (CNTF) is a polypeptide hormone and neurotrophic factor primarily studied in the nervous system. It belongs to the neurokine family of cytokines, which includes other members such as leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and cardiotrophin-1 (CT-1).

Biological Properties

Key Biological Properties: CNTF is a potent survival factor for neurons and oligodendrocytes. It promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations, including astrocytes.

Expression Patterns: CNTF is expressed in various tissues, including the hypothalamus, testicles, tibial nerve, sural nerve, gastrocnemius muscle, substantia nigra, and bone marrow.

Tissue Distribution: The expression of CNTF is prominent in the nervous system, particularly in the hypothalamus, where it plays a crucial role in neuronal survival and function.

Biological Functions

Primary Biological Functions: CNTF supports the survival and differentiation of various neuronal populations. It is involved in promoting the survival of motor neurons, sensory neurons, and astrocytes.

Role in Immune Responses and Pathogen Recognition: While CNTF’s primary functions are in the nervous system, it also has roles in immune responses, particularly in reducing tissue destruction during inflammatory attacks.

Modes of Action

Mechanisms with Other Molecules and Cells: CNTF exerts its effects by binding to a receptor complex consisting of CNTFRα (CNTF receptor alpha), LIFRβ (leukemia inhibitory factor receptor beta), and gp130 (glycoprotein 130).

Binding Partners: The binding of CNTF to its receptor complex triggers the activation of intracellular signaling pathways, including the JAK/STAT pathway, which is crucial for neuronal survival and differentiation.

Downstream Signaling Cascades: Upon binding to its receptor, CNTF activates the JAK/STAT, MAPK/ERK, and PI3K/Akt pathways, which regulate various cellular mechanisms such as metabolism, apoptosis inhibition, and cytoskeletal dynamics .

Regulatory Mechanisms

Transcriptional Regulation: The expression of CNTF is regulated at the transcriptional level by various factors, including stress stimuli and injury responses.

Post-Translational Modifications: CNTF undergoes post-translational modifications that influence its stability and activity. These modifications include phosphorylation and glycosylation, which are essential for its proper function.

Applications

Biomedical Research: CNTF is widely used in research to study neuronal survival, differentiation, and neuroprotection.

Diagnostic Tools: CNTF levels in biological materials, such as blood and tears, are being investigated as potential biomarkers for neurodegenerative and brain diseases.

Therapeutic Strategies: CNTF and its agonists have shown promise in treating neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), as well as retinal degenerative diseases.

Role in the Life Cycle

Development: CNTF plays a critical role in the development of the nervous system by promoting the survival and differentiation of neurons and glial cells.

Aging and Disease: CNTF continues to be important throughout life, contributing to neuronal maintenance and repair. It has potential therapeutic applications in age-related neurodegenerative diseases and conditions involving neuronal damage.