Ciliary Neurotrophic Factor Receptor Rat Recombinant
Ciliary Neurotrophic Factor Receptor Human Recombinant, Sf9
Sf9, Baculovirus cells.
Ciliary-Neurotrophic Factor Mouse Recombinant
Ciliary Neurotrophic Factor Rat Recombinant
Ciliary Neurotrophic Factor Rat Recombinant, His Tag
Ciliary-Neurotrophic Factor Human Recombinant
Ciliary Neurotrophic Factor Human Recombinant, His Tag
Ciliary Neurotrophic Factor Human Recombinant, His Tag Active
Ciliary Neurotrophic Factor Receptor Human Recombinant
Key Biological Properties: CNTF is a potent survival factor for neurons and oligodendrocytes. It promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations, including astrocytes .
Expression Patterns: CNTF is expressed in various tissues, including the hypothalamus, testicles, tibial nerve, sural nerve, gastrocnemius muscle, substantia nigra, and bone marrow .
Tissue Distribution: The expression of CNTF is prominent in the nervous system, particularly in the hypothalamus, where it plays a crucial role in neuronal survival and function .
Primary Biological Functions: CNTF supports the survival and differentiation of various neuronal populations. It is involved in promoting the survival of motor neurons, sensory neurons, and astrocytes .
Role in Immune Responses and Pathogen Recognition: While CNTF’s primary functions are in the nervous system, it also has roles in immune responses, particularly in reducing tissue destruction during inflammatory attacks .
Mechanisms with Other Molecules and Cells: CNTF exerts its effects by binding to a receptor complex consisting of CNTFRα (CNTF receptor alpha), LIFRβ (leukemia inhibitory factor receptor beta), and gp130 (glycoprotein 130) .
Binding Partners: The binding of CNTF to its receptor complex triggers the activation of intracellular signaling pathways, including the JAK/STAT pathway, which is crucial for neuronal survival and differentiation .
Downstream Signaling Cascades: Upon binding to its receptor, CNTF activates the JAK/STAT, MAPK/ERK, and PI3K/Akt pathways, which regulate various cellular mechanisms such as metabolism, apoptosis inhibition, and cytoskeletal dynamics .
Transcriptional Regulation: The expression of CNTF is regulated at the transcriptional level by various factors, including stress stimuli and injury responses .
Post-Translational Modifications: CNTF undergoes post-translational modifications that influence its stability and activity. These modifications include phosphorylation and glycosylation, which are essential for its proper function .
Biomedical Research: CNTF is widely used in research to study neuronal survival, differentiation, and neuroprotection .
Diagnostic Tools: CNTF levels in biological materials, such as blood and tears, are being investigated as potential biomarkers for neurodegenerative and brain diseases .
Therapeutic Strategies: CNTF and its agonists have shown promise in treating neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), as well as retinal degenerative diseases .
Development: CNTF plays a critical role in the development of the nervous system by promoting the survival and differentiation of neurons and glial cells .
Aging and Disease: CNTF continues to be important throughout life, contributing to neuronal maintenance and repair. It has potential therapeutic applications in age-related neurodegenerative diseases and conditions involving neuronal damage .