GHRH Human

Growth Hormone Releasing Hormone Human

Synthetic human growth hormone-releasing hormone is a single, non-glycosylated polypeptide chain composed of 29 amino acids, with a molecular weight of 3358.9 Daltons. This sequence corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone, which consists of 44 amino acid residues. The purification of GHRH is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT13117
Appearance
White, sterile, lyophilized powder.

GHRP 6

Growth Hormone Releasing Peptide-6

Synthetic Growth Hormone Releasing Peptide-6 is a single, non-glycosylated polypeptide chain comprising 6 amino acids. It possesses a molecular weight of 873 Daltons and is represented by the molecular formula C46H56N12O6.
Shipped with Ice Packs
Cat. No.
BT13210
Appearance
White, sterile, and lyophilized (freeze-dried) powder.

GHRP1

Growth Hormone Releasing Peptide-1

Synthetic growth hormone-releasing peptide-1 is a single-chain polypeptide consisting of 5 amino acids. It is not glycosylated and has a molecular weight of 955.11 Daltons. Its molecular formula is C51H62N12O7.

Shipped with Ice Packs
Cat. No.
BT13273
Appearance
Sterile white powder, freeze-dried for preservation.

GHRP2

Growth Hormone Releasing Peptide-2

Synthetic Growth Hormone Releasing Peptide-2 is a single, non-glycosylated polypeptide chain composed of 6 amino acids. It possesses a molecular mass of 817.9 Daltons and is represented by the molecular formula C45H55N9O6.
Shipped with Ice Packs
Cat. No.
BT13367
Appearance
It appears as a sterile, filtered powder that is white in color and has been lyophilized (freeze-dried).

GHRP4

Growth Hormone Releasing Peptide-4

Growth Hormone Releasing Peptide-4 Synthetic is a single chain polypeptide, devoid of any glycosylation. It comprises 4 amino acids, resulting in a molecular weight of 607.73 Daltons. The molecular formula for GHRP4 is C34H37N7O4.

Shipped with Ice Packs
Cat. No.
BT13411
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

GHRP5

Growth Hormone Releasing Peptide-5

Synthetic Growth Hormone Releasing Peptide-5 is a single-chain polypeptide composed of 5 amino acids. It lacks any carbohydrate modifications (non-glycosylated) and has a molecular weight of 770.91 Daltons. Its molecular formula is C43H46N8O6.

Shipped with Ice Packs
Cat. No.
BT13471
Appearance
Sterile white powder obtained by freeze-drying.

Ipamorelin

Ipamorelin

Ipamorelin Synthetic is a single, unbranched chain of 4 amino acids, devoid of any carbohydrate modifications. It has a molecular weight of 711.85 Daltons and is represented by the molecular formula C38H49N9O5.
Shipped with Ice Packs
Cat. No.
BT13539
Appearance
White, freeze-dried powder that has been sterilized by filtration.
Definition and Classification

Growth hormone-releasing peptides (GHRPs) are synthetic, non-natural peptides that stimulate the secretion of growth hormone (GH) from the pituitary gland. They do not share structural homology with growth hormone-releasing hormone (GHRH) and act via specific receptors located in the pituitary and hypothalamus . GHRPs include several peptides such as GHRP-6, GHRP-2, and Hexarelin .

Biological Properties

GHRPs exhibit potent stimulatory effects on somatotrope secretion in both animals and humans . They are characterized by their ability to increase GH levels, which in turn influences various physiological processes. GHRPs are expressed in tissues such as the pituitary gland and hypothalamus . Their distribution is primarily in these regions, where they exert their effects by binding to specific receptors .

Biological Functions

The primary biological function of GHRPs is to stimulate the release of growth hormone, which plays a crucial role in growth, metabolism, and overall physiological regulation . GHRPs also exhibit cytoprotective and cardioprotective properties, making them potential candidates for therapeutic applications in conditions such as myocardial infarction . Additionally, GHRPs have been shown to enhance muscle growth, improve recovery, and increase strength .

Modes of Action

GHRPs exert their effects by binding to specific receptors in the hypothalamus and pituitary gland, known as growth hormone secretagogue receptors (GHSRs) . This binding triggers the release of growth hormone-releasing hormone (GHRH), which then stimulates the pituitary gland to release growth hormone . GHRPs also inhibit the release of somatostatin, a hormone that suppresses GH secretion . The downstream signaling cascades involve various intracellular pathways, including the activation of protein kinase C (PKC) and the influx of calcium ions .

Regulatory Mechanisms

The expression and activity of GHRPs are regulated by several mechanisms. Transcriptional regulation involves the interaction of various transcription factors with the promoter regions of GHRP genes . Post-translational modifications, such as phosphorylation, also play a role in modulating the activity of GHRPs . Additionally, the release of GHRPs is influenced by metabolic conditions, such as glucose and lipid levels, as well as hormonal signals from the hypothalamus .

Applications

GHRPs have several applications in biomedical research and clinical practice. They are used as diagnostic tools to assess growth hormone deficiency and other endocrine disorders . Therapeutically, GHRPs are explored for their potential in treating conditions such as muscle wasting, growth hormone deficiency, and age-related decline in GH levels . Their cytoprotective and cardioprotective properties also make them candidates for treating cardiovascular diseases .

Role in the Life Cycle

Throughout the life cycle, GHRPs play a significant role in regulating growth and development. In childhood and adolescence, they contribute to growth and development by stimulating GH release . In adulthood, GHRPs help maintain muscle mass, bone density, and metabolic functions . As individuals age, the activity of GHRPs decreases, leading to a decline in GH levels and associated physiological functions . However, GHRPs can still exert beneficial effects in older adults by enhancing GH secretion and mitigating age-related decline .

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